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Chapter 11


Carcinogicity the ability of a substance to cause cancer
Hypersensitivity an abnormal sensitivity generally resulting in an allergic reaction
Idiosyncrasy an unexpected reaction the first time a drug is taken, generally due to genetic causes
Complexation when two different molecules associate of attach too each other
Displacement a drug that is bound to a plasma protein is removed when another drug of greater binding potential binds to the same protein
Enzyme Induction the increase of hepatic enzyme activity that results in greater metabolism of drugs
Enzyme inhibition the decrease of hepatic enzyme activity that results in reduced metabolism of drugs
Additive Effects the summation in effect when two drugs with similar pharmaceutical actions are taken
Antidote a drug that antagonizes the toxic effect of another
Pharmacogenomics field of study that defines the hereditary basis of individual differences in ADME
Cirrhosis a chronic liver disease causing loss of function
Hyperthyroidism a condition in which the thyroid secretions are above normal (overactive thyroid)
Hypothyroidism a condition In which thyroid hormone secretions are below normal
obstructive jaundice an obstruction of bile duct that causes hepatic waste products and bile accumulate in the liver
Adverse drug reaction an unintended side effect of a medication that is negative
Anaphylactic shock a potentially fatal hypersensitivity reaction producing severe respiratory distress and cardiovascular collapse
Potentiation when one drug with no inherent activity of its own increases the activity of another drug that produces an effect
Synergism when two drugs with similar pharmacological actions produce greater effects than the sum of individual effects
Drug-diet interactions when elements of ingested nutrients interact with a drug and this affects the disposition of the drug
Created by: awierman20