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Chapter 11
Terminology
Question | Answer |
---|---|
Carcinogicity | the ability of a substance to cause cancer |
Hypersensitivity | an abnormal sensitivity generally resulting in an allergic reaction |
Idiosyncrasy | an unexpected reaction the first time a drug is taken, generally due to genetic causes |
Complexation | when two different molecules associate of attach too each other |
Displacement | a drug that is bound to a plasma protein is removed when another drug of greater binding potential binds to the same protein |
Enzyme Induction | the increase of hepatic enzyme activity that results in greater metabolism of drugs |
Enzyme inhibition | the decrease of hepatic enzyme activity that results in reduced metabolism of drugs |
Additive Effects | the summation in effect when two drugs with similar pharmaceutical actions are taken |
Antidote | a drug that antagonizes the toxic effect of another |
Pharmacogenomics | field of study that defines the hereditary basis of individual differences in ADME |
Cirrhosis | a chronic liver disease causing loss of function |
Hyperthyroidism | a condition in which the thyroid secretions are above normal (overactive thyroid) |
Hypothyroidism | a condition In which thyroid hormone secretions are below normal |
obstructive jaundice | an obstruction of bile duct that causes hepatic waste products and bile accumulate in the liver |
Adverse drug reaction | an unintended side effect of a medication that is negative |
Anaphylactic shock | a potentially fatal hypersensitivity reaction producing severe respiratory distress and cardiovascular collapse |
Potentiation | when one drug with no inherent activity of its own increases the activity of another drug that produces an effect |
Synergism | when two drugs with similar pharmacological actions produce greater effects than the sum of individual effects |
Drug-diet interactions | when elements of ingested nutrients interact with a drug and this affects the disposition of the drug |