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UBC Pharmacology1

Anti-cancer Drugs

Drug nameClassMethod of Action
Cyclophosphamide Alkylating Agent Drug covalently adds alkyl groups to DNA > Crosslinks DNA, ring cleavage, abnormal base pairing > apoptosis
Cisplatin Platinum Compound Covalently binds to DNA > X-links > DNA Damage > Apoptosis
Carboplatin Platinum Compound Covalently binds to DNA > X-links > DNA Damage > Apoptosis
Methotrexate Anti-metabolite, Folate Analogue Inhibits dihydrofolate reductase > depletes cell of folate > blocks DNA synthesis > Cells arrest in S phase
5-Fluorouracil Anti-metabolite, Pyrimidine Analogues Inhibits thymidylate synthase > blocks DNA synthesis > cells arrest in S phase
Thioguanine Anti-metabolite, Purine Analogue Guanine derivative that incorporates into DNA but structural difference inhibits replication and transcription.
Paclitaxel Anti-mitotic Agent, Taxanes Binds to microtubules and inihibits depolymerization step required for cell division > cells arrest in mitosis
Docetaxel Anti-mitotic Agent, Taxanes Binds to microtubules and inihibits depolymerization step required for cell division > cells arrest in mitosis
Vincristine Anti-mitotic Agent, Vinca Alkaloids Drug binds tubulin monomers and prevents tubulin polymerization needed for cell division > cells arrest in mitosis.
Vinblastine Anti-mitotic Agent, Vinca Alkaloids Drug binds tubulin monomers and prevents tubulin polymerization needed for cell division > cells arrest in mitosis.
Doxorubicin Topoisomerase Inhibitor Intercalates into DNA > Interferes with transcription > generates O2 Free radicals > DNA damage (strand breakage)
Topotecan Topoisomerase Inhibitor Interferes with transcription >> Growth arrest??
Bleomycin Antitumour Antibiotic Binds DNA and Fe2+ > Generates free radicals > results in DNA damage
Tamoxifen Anti-Estrogen Antagonist Competes with estrogen for receptor binding
Anastrozole Aromatase Inhibitor Prevents estradiol synthesis
Letrozole Aromatase Inhibitor Prevents estradiol synthesis
Gosrelin LHRH Analogue Blocks testosterone production via the pituitary
Leuprolide LHRH Analogue Blocks testosterone production via the pituitary
Flutamide Anti-Androgen Antagonist Competes with androgens for receptor binding
Cetuximab Monoclonal antibody MAb directed against extracellular portion of receptor - competitive inhibition of ligand binding, eg EGFR
Trastuzmab Monoclonal antibody MAb directed against extracellular portion of receptor - competitive inhibition of ligand binding, eg Her2
Bevacizumab Monoclonal antibody MAb targetting the ligand, eg VEGF
Erlotinib Tyrosine kinase inhibitor cepetes with the ATP binding at the TK domain
IFN-alpha Anti-angiogenic blocks VEGF and bFGF gene transcription adn translation
Marimastat Anti-angiogenic Matrix metalloproteinase inhibitors which prevent the breakdown of the extracellular matrix.
Neovastat Anti-angiogenic Matrix metalloproteinase inhibitors which prevent the breakdown of the extracellular matrix.
Created by: jtwalker
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