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AntiVirals
Pharm Y2B2
| Drug | Indication |
|---|---|
| Acyclovir | enzyme thiamine kinase |
| Acyclovir | good for pregrancy, children |
| Acyclovir | renal dsyfxn, phlebitis |
| Valcyclovir | TTP/HUS |
| Acyclovir, Pencyclovir, Docosanol | Topical |
| Docosanol (Abreva) | inhibits fusion btw HSV and plasma membrane |
| Triflurodine | Ocular drug: inhibition of thymidylate synthetase |
| Foscavir | acyclovir et al. resistant HSV, VZV |
| Acyclovir | DOC for CNS, visceral, disseminated inf. |
| Ganciclovir | UL97 |
| Ganciclovir | teratogenic, mutagenic, myelosuppression, liver/kidney dys |
| Valganciclovir | PO prodrug of ganciclovir, effects similar to ganciclovir |
| Foscavir | inhibits DNA/RNA polymerase |
| Foscavir | 2nd in line for CMV |
| Foscavir | deposited in bone, TOXIC: nephrotoxic, eletrolyte imbalance, GI, bone marrow suppression |
| Cidofovir | monophosphate kinase, pyruvate kinase |
| Cidofovir | competitive inhibitor, alternate substrate for CMV DNA |
| Cidofovir | nephrotoxic, neutropenia, metabolic acidosis |
| Ganciclovir, Fomivirisen | Ocular CMV |
| Fomivirisen | last hope for CMV retinitis, binds to mRNA |
| Foscavir, Cidofovir | IV only |
| Ganciclovir resistance | mutation in UL97, mutation in DNA polyermase |
| Rimantadine | hepatically metabolized |
| Rimantadine, Amantadine | blocks viral uncoating |
| Amantadine | not used in Parkinson's |
| Rimantadine/Amantadine | prevention and tx of flu A, GI, CNS: anxiety |
| o Oseltamivir / Zanamivir | neuraminidase inhibitors (budding of virus) |
| Oseltamivir / Zanamivir | prevention and tx of flu a and b |
| Oseltamivir | PO, prodrug, severe vomiting, neuraminidase inhibitor |
| Zanamivir | inhalation only, rare resistance |
| Oseltamivir / Zanamivir | more effective for flu tx |
| Acyclovir, Famclycovir, Valcyclovir | HSV (genital/oral) and VZV |
| resistance to acyclovir | deficient in TK, altered substrate specificity, altered viral DNA polymerase enzymes |
| acyclovir, ganciclovir, foscavir, cidovir, rimantadine/ amantadine, oseltamivir | Renally cleared |
| zovirax, denavir | prescription only |
| Lamivudine, Adefovir | Nucleotide Reverse Transcriptase Inhibitors |
| Nelfinavir | protease inhibitor that doesn't interact w/ CYP 3A4 |
| Delavirdine, Nevirapine, Efavirenz | NNRTI |
| Efavirenz | CNS effects, X pregnancy (NNRTI) |
| Neviraphine | severe hepatoxicity, lots of rash (NNRTI) |
| Efavirenz, Nevirapine | common NNRTI |
| NNRTI | alters active site of enzyme and inactivates it, common cross-resistance |
| NRTI | competitively inhibits enzyme reverse transcriptase |
| NRTI | mitochondrial toxicity, lipoatrophy |
| Lamivudine, Tenofovir | NRTI, well tolerated |
| Abacavir | GOOD NRTI |
| Enfuvirtide | fusion inhibitors, not rec as 1st line therapy |
| Fusion Inhibitors | MOA: binds to gp41 |
| Imiquimod (Aldera) | cream, HPV (all warts) |
| Palivizumab | IM (monoclonal antibody) |
| Palivizumab | RSV, give to high risk infants |
| Ribavirin | Pregnancy X, never as monotherapy for Hep C, hemolytic anemia |
| Efavirinz, Ribavirin | X Pregnancy |
Created by:
fl_sun80
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