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pharm midterm2

QuestionAnswer
The two families of Calcium Channel Blockers Dihydropyridnies (suffix -ipine) Non-dihydropyridines
What do Calcium Channel blockers do reduce peripheral resistance decrease blood pressure elicit antianginal/antiarrhythmic effects
MOA of CCB inhibition of calcium influx into arterial smooth muscle cells
CCB PK/PD L-type are the most dominant in cardiac/smooth muscle Dihydro - are more selective as vasodilators and have less cardiac depression. verapamil has greatest cardiac depressive effects
CCB clinical indications HTN, Angina supraventricular tachyarrhythmias, hypertrophic cardiomyopathy, migraine, raynaud's phenomenon
CCB toxicity arrest, bradycardia, av block, heart failure
end product of RAAS renin-angiotension-aldosterone-system arteriolar vascoconstriction, increase in blood pressure
ARB general block angiotension II type I receptors very selective -rtan as suffix for meds most effective
ARB pk/pd short half-life, moderate bioavailability, no effect on bradykinin metabolism
ARB tox do not use during pregnancy may cough and angioedema
ACE-I general block angiotension converting enzyme, stops the conversion from I to II. suffix for meds: -pril.
ACE-I PK/PD eliminated by the kidneys, therefore, dose must be reduced in patients with renal insufficiency. fairly well administered orally and mod long half-life
ACE-I tox severe hypotension, acute renal failure, hyperkalemia, dry consistent cough, dry cough, angioedema, do not use during pregnancy
gram positive cocci cluster: staphylococci
gram positive bacilli bacillus
gram negative cocci neisseria meningitidis
gram negative bacilli citrobacter
anaerobes above the belt prevotella
below the belt anaerobes fusobacterium
atypical bacteria mycoplasma legionella chlamydia
ID vignettes errors contamination, sample size, results to match to symptoms, lines present, test before antibiotics
ID vignettes bacteria S. viridans (endocarditis, post-dental) N. meningitidis (meningitis) Acinetobacter (ICU, ventilators) Anaerobes (diabetics, PNA)
Empiric therapy (ID vignettes) medication that targets a broad range of bacteria
Normal flora Strep is found skin, oropharynx, GU, heart
Normal Flora Staph is found Nasopharynx, heart
Normal flora E.coli urinary, GU
Created by: lilram
 

 



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