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MDA Blankenship

MDA-Midterm

DRUGMDAIndication
Physostigmine Reversible cholinesterase Inhibitor Glaucoma (tertiary amine)
Neostigmine Reversible cholinesterase Inhibitor postoperative/post partum atony of GI tract or urinary bladder, Myasthenia gravis
Diisopropylfluorophosphate (DFP) Irreversible cholinesterase Inhibitor (binds to OH is esteric site) pesticide/nerve gas (organophosphate)
Echothiophate Irreversible cholinesterase Inhibitor (binds to OH is esteric site) Glaucoma (organophosphate)
Pralidoxine (2PAM) Cholesterase reactivator binds to anionic site on cholinesterase to remove organophosphate
Atropine competitive, muscarinic antagonist control GI sensitivity; decrease respitory secretion; increase HR (CNS excitation)
Scopolamine muscarinic antagonist insomnia; preansthetic agent; motion sickness (CNS depressant)
Quaternary amines: Propantheline, Clidinium muscarinic antagonist Periphery effects, decrease GI motility; antispasmotic No CNS side effects
Homotropine, Tropicamide muscarinic antagonist dilation of the eye (Mydriatic Agents)
Ipratropium Bromide muscarinic antagonist COPD (blocks bronchoconstriction)
Mecamylamine nicotinic antagonist (Ganglionic blocker) severe hypertension
Pancuronium Bromide, Atracurium, Mivacurium Competative neuromuscular Junction blocker general ansthetics; severe convulsions
Succinylcholine Non-Competative neuromuscular Junction blocker general ansthetics; severe convulsions
Norepinephrine (Levarterenol) α1, α2, β1 agonist primary cardiovascular effects
Epinephrine α1, α2, β1, β2 agonist Cardiac stimulation, anaphylaxis, asthma
Isoproterenol β1, β2 agonist Bronchodilator (reflex tachycardia)
Dobutamine Selective β1 agonist Cardiac stimulant
Dopamine (DA) D1 agonist
Tyramine (also from aged food) Indirect - replaces NE in the vesicle causing its release and response NE effectsα1 vasoconstriction; β1 cardio stimulant (Amphetamine - crosses BBB) Tolerance due to lack of NE left
Ephedrine Indirect - Replaces NE and has direct β2 agonist properties bronchodilator(crosses BBB)
Pseudoephedrine Indirect - optical isomer of Ephedrine - indirect releaser of NE nasal decongestant (vasoconstriciton)
Phenylpropanolamine Indirect - looks allot line NE and EPI - indirect releaser
Methylphenidate indirect releaser ADHD; appetite suppression
Cocaine Indirect - NE and Epi reuptake blocker
Phenylaphrine direct - selective α1 agonist nasal decongestant spray (vasoconstriciton), induce mydriasis
Clonidine direct - selective α2 agonist antihypertensive
Metaproterenol, Terbutaline, Albuterol, Salmeterol β2 agonist bronchodilator; prevention of premature delivery,
Prazosin competitive reversible α1 antagonist antihypertensive
Phenoxybenzamine Non-competitive irreversible α1, α2 antagonist control BP during surgery; Reynaud's syndrome
Propranolol competitive β1, β2 antagonist anti-hypertensive; anti-angina; anti-arrhythmic; thyrotoxicosis; Anti-anxiety
Metoprolol β1 antagonist antihypertensive, can be used in asthma
Labetulol, Carvedilol α1, β1, β2 antagonist antihypertensive
Bethanechol Muscarinic Agonist postoperative/post partum atony of GI tract or urinary bladder
Created by: clamattina
Popular Pharmacology sets

 

 



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