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Neuro3 drugs
easy ones
| Question | Answer |
|---|---|
| Epinephrine | Adrenergic Agonist (ALL) Used for acute asthma, anaphylactic shock, open-angle glaucoma and cardiac resuscitation |
| Norepinephrine | Adrenergic Agonist (alpha > beta) Used for hypotension, but it decreases renal profusion |
| Phenylephrine | Adrenergic Agonist (alpha-1) used for papillary dilation, vasoconstriction and nasal decongestion-- increases BP |
| Clonidine | Adrenergic Agonist (alpha-2) Used for hypertension, especially with renal disease because there is no decrease in flow to kidneys |
| Isoproterenol | Adrenergic Agonist (B 1 and 2) used for treatment of acute heart failure and acute asthma |
| Norepinephrine | Adrenergic Agonist (B1) |
| Dobutamine | Adrenergic Agonist (B1) used for shock, heart failure and cardiac stress testing |
| Albuterol | Adrenergic Agonist (B2) used for acute asthma attacks |
| Carvedilol, Labetalol | Adrenergic Antagonist (all) |
| Phenoxybenzmine | Adrenergic Antagonist (A 1 and 2) IRREVERSIBLE. Used to treat benign prostatic hyperplasia, pheochromocytoma related to HTN. Side effects include orthostatic hypotension and reflex tachycardia |
| Phentolamine | Adrenergic Antagonist (A 1 and 2) reversible |
| "Zosin" drugs (Prazosin, terazosin, doxazosin) | Adrenergic Antagonist (A1) Used for HTN, urinary retention. Side effects include orthostatic hypotension, inhibition of ejaculation, reflex tachycardia, nasal congestion and miosis |
| Yohimbe | Adrenergic Antagonist (A2) |
| Mirtazapine | Adrenergic Antagonist (A2) used for depression. Side effects includ sedation, high cholesterol and increased appetite |
| Olol drugs (A-BEAM acebeutolol, esmolol, atenolol, metoprolol) | Adrenergic antagonists (B1) Used for HTN, glaucoma, migraines, angina, MI prophylaxis |
| Propanolol | Adrenergic antagonist (B1 and B2) Used for HTN, glaucoma, migraines, angina, MI prophylaxis. Don't use in patients with COPD and asthma |
| Butoxamine | Adrenergic Antagonist (B2) |
| A1 receptor | adrenergic receptor Q increases IP3 and Ca vasoconstriction |
| A2 receptor | adrenergic receptor I decreases cAMP decreases sympathetic stimulation (relax/dilation of GI and decreased release of insulin) |
| B1 receptor | adrenergic receptor S increase cAMP (adenylate cyclase) increases HR, renin, lipolysis and aqueous humor |
| B2 receptor | adrenergic receptor S increases cAMP (adenylate cyclase) bronchodilation and vasodilation |
| Ach overdose | DUMBBELLS diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal muscle and CNS, lacrimation, sweating, and salivation |
| Carbachol | muscarinic and nicotinic agonist used for glaucoma management |
| Nicotine | nicotinic agonist |
| Succinylcholine | Nm agonist leads to depolarizing block |
| Curare | Nm antagonist Used as NMJ blocker for surgical anesthesia |
| Hexamethonium | Nn antagonist used in experimental models to prevent vagal reflex responses to changes in BP. Side effects include severe orthostatic hypotension, blurred vision, constipation, sexual dysfunction |
| Bethanechol | Muscarinic Agonist Used to treat post-op urinary retention and atonic ileus. Resistant to acetylcholinesterase. |
| Pilocarpine | Muscarinic Agonist used to treat glaucoma |
| Atropine | Muscarinic antagonist Used with pralidoxime (AchE regenerator) to treat cholinesterase inhibitor poisoning. Side effects make you "blind as a bat, red as a beet, mad as a hatter, hot as a hare, dry as a bone." |