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Module 1
Definitions
Term | Definition |
---|---|
drug | any chemical that can affect a living process |
pharmacology | study of drugs and their interactions with the living systems |
clinical pharmacology | study of drugs in a human |
therapeutics | also known as pharmacotherapeuctics, the use of drugs to diagnose, prevent, or treat diseases and pregnancy |
ideal drug | effectivness, safety, selectivity |
effectiveness | effective drug is one that elicit the response for which it is given |
safety | one that cannot produce harmful effects, even administered in high doses for long periods |
selectiveness | one that elicits only the response for which it is given |
therapeutic objective | provide maximum benefits with minimal harm |
pharmcokinetics | process in which determine how much of an administered dose gets to its site of action |
pharmacodynamics | impact of drugs on the body |
adverse effect | undesirable, unexpected and potentially dangerous response to medication. slow or fast acting |
adverse interactions | drug to food or drug to drug interaction |
toxicity | quality of being toxic or posonous |
absorption | movement of a drug from its site of administration into the blood |
distribution | movement of drugs throughout the body |
metabolism | aka biotransformation, the enzymatic alteration of a drug structure |
excretion | removal of drugs from the body |
enternal | involving or passing through intestine either naturally via the mouth and esophagus or through an artificial opening |
parenternal | administered or occurring elsewhere in the body than the mouth and alimentary canal |
protein binding | drugs bind with protiein |
maximal efficacy | maximum effect a drug can produce, regardless of the dose |
therapeutic index | comparison of the amount of a therapeutic agent that causes therapeutic effect to the amount that causes toxicity |
effective dose | the amount of a drug, or level of radiation exposure, that is sufficient to achieve the desired clinical improvement |
agonist | a substance that acts like another substance and therefore stimulates an action |
antagonist | a substance that acts against and blocks any action |
partial agonist | drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist |
side effects | undesirable effect of a drug or medical treatment |
allergic reaction | the hypersensitive response of the immune system of an allergic individual to a substance |
idiosyncratic effect | uncommon response to a drug, because of a genetic predisposition |
latrogenic disease | result of a diagnostic and therapeutic procedure undertaken on a patient |
physical dependence | state in which the body has adapted to drug experience in a way that if discontinued would cause abstinence syndrome |
carcinogenic effect | substance or agent that has the ability to produce cancer |
terogentic effect | drug induced birth defects |
hepatoxicity | drugs that are metabolized by the liver and are converted to toxic products |
pharmacodynamic tolerance | the familiar type of tolerance associated with long term administration of drugs such as morphine and heroin |
metabolic tolerance | tolerance resulting from accelerated drug metabolism |
placebo effect | as that component of any drug response that is caused by physiologic factors not biochemical |
bioavailability | amount of active drug that reaches the systemic circulation from its site of administration |
half-life | time required for the amount of drug in the body to decrease by 50% |
onset | the amount of time it takes for a drug to take action in the body |
peak | highest concentration level |
duration | an amount of time the drug is taken and wears off |
PRN | as needed |
ADPIE | assess, diagnose, plan, implement, evaluate |
superinfection | develop an infection |
prophylactic | given to prevent infection |