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Platelets (PLTs)

CAD, Myocardial Infarction (MI)

Platelets (PLTs) platelet aggregation inhibitors (antiplatelet agents) Aspirin (ASA, NSAID- pharm class) anti platelet properties Plavix (clopidogrel)
Mechanism of Action (1) 1. Works in cyclooxygenase (COX) pathway in platelets --> inhibits formation of thromboxane A2 --> decreases vasoconstriction and platelet aggregation
Mechanism of Action (2) 2. ADP inhibitor -->prevents platelet membrane from receiving to aggregate (glycoprotein IIb/IIIa receptor)
Therapeutic effect Inhibits platelet aggregation
Indications 1. Coronary Artery Disease (CAD) 2. Myocardial Infarction (MI) 3. Thrombotic storke
Precautions 1. Bleeding 2. Clopidogrel-concurrent use with some proton pump inhibitors (PPIs) *Protonix (pantoprazole ok)
Contraindications 1. Active bleeding; GI Ulcer; recent hemorrhagic stroke 2. Thrombocytopenia *decrease platelets
Side Affects 1. Active bleeding: obvious/ occult 2. Thrombocytopenia *decrease platelets 3. GI upset
Nursing Actions 1. Monitor bleeding 2. Follow CBC/ hemogram 3. Patient ed: drug/side effect, symptoms of bleeding, interactions.
Labs 1 1. Lipid Profile--- general recommendations
Lipid Profile a. Total Cholesterol <200
Lipid Profile b. High density lipoprotein (HDL) *women>50, men>60
Lipid Profile c. Low Density lipoprotein < 120
Lipid Profile d. Triglicerides: <150
Labs 2 2. Liver function tests (LFTs); serum glucose
Labs 3 3. Complete Blood Count (CBC)/ hemogram/ platelets
Labs 4 4. Hemocysteine, C --reactive protein (CRP)
CAD progresses -->Coronary Ischemia (decrease blood flow and oxygen to myocardium)
Created by: azmedina