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Fibric Acid Derivatives (fibrates)

Fibric Acid Derivatives (fibrates) Indication: Hypertriglyceridemia Lopid (gemfibrozil) *works in the liver
Mechanism of action 1. Decrease hepatic uptake of free fatty acids (decrease triglyceride production) 2. Inhibits lipolysis of fat (breakdown of of fats and lipids by hydrolysis to release fatty acids)
Therapeutic Effect 1. primary triglyceride lowering agents 2. some effect on total cholesterol
Precautions 1. Renal or hepatic dysfunction 2. Multiple drug interaction; HMG-CoA Reductase Inhibitor
Contraindications Severe kidney, liver, or gall bladder disease
Side Affects Abdominal discomfort, nausea, vomiting, headache
Nursing actions 1. Follow lipid profile 2. Caution when other drugs given concurrently
Created by: azmedina