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HMG- CoA reductase Inhibitor

HGM- CoA reductase inhibitors ("statins") Lipitor (atorvastatin ) Zocor ( simvastatin)
Mechanism of Action 1. Inhibit the HMG- CoA reductase enzyme activity in the liver 2. Decreases cholesterol synthesis
Therapeutic effect 1. Decreases total collateral 2. May affect individual types of cholesterol •HDL, LDL etc.
Precautions 1. Hyperglycemia 2. Pre-existing muscle weakness 3. Altered neuro status; pre-existing confusion/dementia 4. Liver dysfunction (elevated liver function test LTSs)
Contraindications 1. Pregnancy category x 2. Liver dysfunction 3. Renal insufficiency/ failure due to rhabdomyolysis, trauma
Side Effects 1. Hyperglycemia 2. Myopathy (muscle weakness) rhabdomyolysis (breakdown of skeletal muscle that travels to kidney for excretion)! 3. Headache, memory loss, confusion 4. Gastrointestinal (GI) disturbances, liver dysfunction
Nursing Actions 1. Optimal dosing time: nocturnal 2. Assess: neuro function, muscle weakness, glucose control, GI symptoms, Urinary changes 3. Drug interactions (CYP 450)! 4. Follow lipid Panel; monitor glucose and LFTs
Created by: azmedina