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Pharm. Chapter 5

Pharmacodynamics

QuestionAnswer
The amount of drug we must give to elicit an effect Potency
Drugs that mimic the body's regulatory molecules are called: Agonists
Drugs that block the actions of endogenous regulators are: Antagonists
Study of the biochemical and physiologic effects of drugs and the molecular mechanisms by which those effects are produced Pharmacodynamics
The therapeutic index is defined as: A measure of a drug's safety ratio of a drug's Ld50 (lethal dose to 50%) to it ED50 (Effective Dose to 50%)
The greatest effect a drug can produce is: Maximum Efficacy
The four primary families of receptors are: -Cell membrane-embedded enzymes-Ligand-gated ion channels-G protein-coupled receptor systems
The function of the transcription factors is to __________. Regulate protein synthesis
A _________ is any functional macromolecule in a cell to which a drug binds to produce its effects Receptor
When the receptors ofa cell are continually exposed to an agonist, the cell usually becomes less responsive; the cell is said to be _________ or ________ or to have undergone __________. -Desensitized or Refractory-Down-Regulation
Affinity refers to _________ Strength
Intrinsic Activity refers to _________ Ability
Popular Pharmacology sets

 

 



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