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MCW Antibacterial

MCW Antibacterial Mechs

QuestionAnswer
competitively inhibits dihydrofolate reductase Trimethoprim
Competitively inhibit dihydropteroate synthetase Sulfamethoxazole; Silver Sulfadiazine
Binds 50s and blocks translocation step in protein synthesis Erythromycin; Clindamycin
Binds 50s interfering with translation 70s initiation complex Linezolid
Interferes with binding of aminoacyl-tRNA to 50s subunit and inhibits peptide bond formation Chloramphenicol
Binds 30s ribosome subunit and blocks aminoacyl-tRNA entry, ALSO binds additional unique sites in the ribosomes Tigecylcine
Transported into cells, bind to 30s ribosomal subunits, prevent attachment of aminoacyl-tRNA to the acceptor site Tetracylcines---doxycycline, minocycline
Transported into the cell by an energy-requiring aerobic process. It binds to several ribosomal sites, usually 30s/50s to stop initiation and cause mRNA misreading. It has a post-antibiotic effect. Aminoglycosides---Tobramycin, Amikacin, Gentamicin
Anaerobes reduce the nitro group into a free radical that disrupts RNA Metronidazole
Inhibits bacterial RNA synthesis by binding to RNA polymerase B Rifampin
Nitroreductase enzyme converts them to reactive compounds which can damage DNA...including free radicals Nitrofurantoin
Bind alpha subunit of DNA gyrase to inhibit DNA supercoiling norfloxacin, ciprofloxacin, moxifloxacin
Bind bacterial membrane to cause rapid depolarization Daptomycin
cationic detergent that disrupts bacterial membranes Polymyxin B
Interfere with carrier that moves early cell components through membrane...cell wall inhibitor Bacitracin
Inactivate enolpyruvyl transferase; a cell wall synth enzyme Fosfomycin
Binds D-Ala-D-Ala to interfere with crosslink and elongation of peptidoglycan Vancomycin
Created by: DocTwiz
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