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BIM Final Review 2

Lecture 3: Biomechanics and TE

Bone heals, cartilage doesn’t. Why? Cartilage isn't vascular
water, collagen (types I and II), glycosaminoglycans (GAG) Cartilage composition
Biomechanical forces can make cartilage Important in development to differentiate stem cells Normal loading is important in maintaining cartilage Can enhance regeneration Can be used in vitro in a bioreactor to help engineer more native-like neocartilage
Biomechanical forces can break cartilage Create osteoarthritis
Cartilage loading cycles per year 1-2 million cycles
Tissue engineering paradigm Cells, bioactive factors/signals, scaffolds
Recent work shows elements of paradigm can be used in combination or alone
The self-assembling process is a method to engineer cartilage that only requires cells Can use signals, but not needed. The process is scaffold-less
The self-assembling process Isolation of chondrocytes, seeding cells into cylindrical agarose mold, self-assembly into engineered cartilage
Stem cells can also be chondro-induced and self-assembled to form engineered cartilage Dermis isolated adult stem (DIAS) cells
Translating engineering advances to medicine (TEAM) Facility 3D scanning, design software, 3D printers, analysis software, catheter manufacturing, laser cutting/engraving, printed circuit board manufacturing Wet lab equipment, synthetic biology design, innovation space
Technology transfer paradigm Academic research, new technology, new company
Created by: 1543931625634163