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pharm test 1 part 2

Test 1 drugs- AE, PD, CNS stimulants lilk8tob

phenobarbital- general class barbiturate
phenobarbital- used for prevention of grand mal seizures & fever-induced convulsions, hyperbilirubinemia in neonates, Gilbert syndrome
phenobarbital- other long-acting, rarely used as a sedative-hypnotic agent
tamazepam (Restoril)- general class benzodiazepines
tamazepam (Restoril)- used for for short-term treatment of insomnia
tamazepam (Restoril)- other not for narrow-angle glaucoma, preg X
zaleplon (Sonata)- general class benzodiazepines
zaleplon (Sonata) used for short term (up to 5 weeks) treatment of insomnia
zaleplon (Sonata)- other short acting nonbenzodiazepine hypnotic agent. However, its hypnotic effects do arise from chem. activity @ benzo-GABA receptor complex; very short half-life
zolpidem (Ambien)- general class benzodiazepines
zolpidem (Ambien) - used for short term (7-10 days) treatment of insomnia
zolpidem (Ambien)- other short acting, no active metabolites so have less grogginess next morning
baclofen (Lioresal)- general class muscle relaxant
baclofen (Lioresal)- used for spasticity
baclofen (Lioresal)- other central-acting
cyclobenzaprine (Flexaril) - general class muscle relaxant
cyclobenzaprine (Flexaril)- used for spasticity
cyclobenzaprine (Flexaril)- other central-acting; structurally and pharmacologically related to tricyclic antidepressants
choral hydrate (Noctec)- general class misc. CNS depressant
choral hydrate (Noctec)- used for sedative-hypnotic
choral hydrate (Noctec)- other does not suppress REM; low hangover effect from short duration of action; high doses cause dependence; take w/ alcohol=lose consciousness
tizanidine (Zanaflex)- general class misc. CNS depressant
tizanidine (Zanaflex)- used for decreases increased muscle tone associated with spasticity
tizanidine (Zanaflex)- other short-acting, centrally active alpha-adrenergic receptor agonist
List the 8 CNS depressant drugs: phenobarbital, Restoril, Sonata, Ambien, baclofen, Flexaril, choral hydrate, Zanaflex
carbamazepine (Tegretol)- general class AE
carbamazepine (Tegretol)- used for treatment of epilepsy in adults & children, trigeminal neuralgia, tonic-clonic seizures
carbamazepine (Tegretol)- other 2nd most prescribed AED, chemically related to tricyclics; undergoes autoinduction
gabapentin (Neurontin)- general class misc. AE
gabapentin (Neurontin)- used for an add-on agent for the treatment of partial seizures & partial seizures w/ secondary generalization in adults, also treats neuropathic pain
gabapentin (Neurontin)- other probably works by increasing the synthesis & accumulation between neurons in GABA
phenobarbital (Solfoton)- general class barbiturate- AE
phenobarbital (Solfoton)- used for controlling tonic-clonic and partial seizures; status epilepticus, convulsions
phenobarbital (Solfoton)- other SE: sedation, an "inducer" of hepatic enzymes; has longest half life (once a day dosing), cheapest AE
phenytoin (Dilantin)- general class AED
phenytoin (Dilantin)- used for first-line AED; tonic-clonic; psychomotor seizures
phenytoin (Dilanin)- other lethargy, abnormal movements, confusion, is highly protein bound & induces hepatic microsomal enzymes
valproic acid (Depakote)- general class AE
valproic acid (Depakote)- used for generalized seizures (absence, myoclonic, and tonic-clonic), partial seizures
valproic acid (Depakote)- other toxic to liver, weight gain, sleepy, gum hypertrophy
Serum level: carbamaxepine (Tegretol) 6-12 mcg/ml
serum level- valproic acid (Depakote) 50-100 mcg/ml
serum level- phentoin (Dilantin) 10-20 mcg/ml
levodopa-carbidopa (Sinemet)- general class antiparkinsonian - dopaminergic
levodopa-carbidopa (Sinemet)- used for replaces dopamine in parkinson's patients
levodopa-carbidopa (Sinemet)- other does not cross the BBB, but does prevent metabolism of levodopa to dopamine in the periphery, which limits peripheral dopamine-induced side effects; lower daily dose needed; limits on-off; do not take w/ MAOI's
selegiline (Eldepryl) -general class MAOI - antiparkinsonian
selegiline (Eldepryl)- uses parkinson's disease- decreases the amount of levodopa needed; exerts a neuroprotective effect when started early in therapy
selegiline (Eldepryl) - other an MAO-B inhibitor used as an adjuncitve agent along w/ levodopa to decrease the amount of levodopa needed
benztropine mesylate (Cogentin)- general class anticholinergic Antiparkinsonian
benztropine mesylate (Cogentin)- uses Parkinson's disease; drug-induced extrapyramidal symptoms
methylphenidate hydrochloride (Ritalin)- general class CNS stimulant, amphetamine
methylphenidate hydrochloride (Ritalin)- uses treatment of ADHD and narcolepsy
list antiparkinsonian drugs (3) levodopa-carbidopa, selegiline, Cogentin
list CNS stimulant Ritalin
list AE drugs Tegretol, Neurontin, Solfoton, Dilantin, Depakote
Created by: lilk8tob



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