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Pharm Unit 17

SPC Pharmacology Unit 17 Exam 6

Somatic Nervous System deals with what? Skeletal System
What receptors deals with the Somatic Nervous System? Nicotinic II Receptors
How many receptors are in the Somatic Nervous System? 1 Nicotinic II Receptor
What is the single neurotransmitter with Somatic Nervous System? Acetylcholine (Ach)
What does Acetylcholinesterase do? Terminates Neurotransmitter (Ach) and allows repolarization
What terminates Acetylcholine? Acetylcholinesterase
Peripheral Acting Drugs are administered through.... IV (Intravenous)
T/F Peripheral Acting Drugs are Dose Dependent? True
Peripheral Acting Drugs does what? Interferes with N2 receptors at the muscle
What are the two types of Neuromuscular Blockers? Non-depolarizing & Depolarizing
Which type of Neuromuscular Blocker can be reversed with an antidote? Non-depolarizing Blocker
Which type of Neuromuscular Blocker can NOT be reversed with an antidote? Depolarizing Blocker
How is both Depolarizing and Non-Depolarizing administered? Injection or IV
Onset of Non-depolarizing N/M Blocker? 3-5min
Duration of Non-Depolarizing N/M Blocker? 20-30min
T/F Non-depolarization is an antagonist? True
What does Depolarizing Neuromuscular Blockers do? Stimulates N2 receptor then blocks it
Non-Depolarizing Neuromuscular Blockers can cause..... Malignant hyperthermia/Spike Potassium levels/Fasciculations
T/F Depolarizing is fast acting? True
T/F Non-Depolarizing is fast acting? False
Depolarizing Neuromuscular Blockers can cause..... Contractions then N2 receptor is blocked
ALWAYS give what with paralytics? Analgesics (pain meds) & Sedatives
T/F Analgesics and Sedations should be given with paralytics? True
"ALWAYS REMEMBER" Patients with paralytics can still what? Hear, Feel, & Smell when paralyzed
What CANT patients do when paralyzed? Move or Speak
Without Analgesics.... Pain is present
Without Sedations.... Stress & Fear is present
T/F Keep eyes moist under a paralytic? True
What is the antidote for Non-depolarizing Neuromuscular Blockers? Prostigmine (Neostigmine)
Train of Four is used.... To asses the degree of paralysis
What is the process of Train of Four? (2 Step Process) (Step 1) A small electrical device gives a micro-electrical shock to the hand. (Step 2) Count the # of twitches EX. 4 twitches= <75% block & 3 twitches= 90% block & 2 twitches= 95% block & 1 twitch= 98% block
What is significant to remember with use of Train of Four. The patient should be reversed to have some movement every 24hrs to reduce possible long term complications.
What does anticholinesterase promote? Skeletal Muscle Contractions
Anticholinesterase medications potentiates what? Ach at N2 receptor by inhibition of acetylcholinesterase
What medication is used to diagnose (Dx) Myasthenia Gravis? Tensilon
If a patient has Myasthenia Gravis how would you know? Quick onset and ultra short acting but the patient will get stronger.
What are the 2 medications for maintenance of Myasthenia Gravis? Eserine (Physostigmine) & Mestinon (Pyridostigmine)
Eserine and Mestinon are both what type of medications? Maintenance drugs for MG (Myasthenia Gravis)
Incorrect Dosing drugs for Myasthenia Gravis causes what? Under dose is "Myasthenia Crisis & Overdose is "Cholinergic Crisis both of which the patient becomes weaker.
What are two types of Non-Depolarizing Medications? Norcuron & Zemuron
What are the anitdotes for Norcuron and Zemuron? Edrophonium, & Prostigmine (Neostigmine)
Norcuron is also known as what? Vercuronium
Zemuron is also known as what? Rocuronium
What is best known for Norcuron and Zemuron as Non-Depolarizing NM Blockers? They are known to have few or low incidence of adverse cardiovascular effects
Created by: Langhout1418