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MCW Anti-Virals

MCW Anti-Virals mechs and uses

QuestionAnswer
Block Viral uncoating by interfering with a M2 protein channel Amantadine
Competitive inhibitor of influenza neuramindases; interferes with release and penetration Oseltamivir
Used for treatment of uncomplicated Influenza A and B Oseltamivir
Prophylaxis against influenza, NOT used for influenza B Amantadine
How does TRIFLURIDINE interfere with DNA synthesis? Interferes with DNA synthesis as a thymidine analog
Used as ophthalmic treatment for HSV type 1 &2 Trifluridine
Prodrug that acts as a competitive inhibitor of dGTP and DNA chain terminator in phosphorylated form. Acyclovir
Acts similar to acyclovir and is converted to penciclovir Famciclovir
1.Intravenous use for Acyclovir 1. serious systemic herpes simplex
Used for___________and supression of _____________ Acute herpes zoster (shingles); recurrent genital herpes
Penciclovir is used for________as a topical Recurrent herpes to lips and face
Monophosphorylation of acyclovir is catalyzed by ________ while monophosphorylation of ganciclovir is catalyzed by _______ Herpes thymidine kinase; CMV protein kinase
These three are used for the treatment of CMV retinitis in AIDS patients ganciclovir, foscarnet, fomivirsen
This is used for CMV prophylaxis in transplant patients ganciclovir
This drug selectively inhibits CMV DNA polymerase by binding to pyrophosphate binding site. Foscarnet
Approved for use in acyclovir resistant herpes simplex Foscarnet
Nucleoside analog inhibitor of the reverse transcriptase domain of hepatitis B DNA polymerase Lamivudine
Antisense nucleic acid that inhibits gene expression or replication of CMV Fomivirsen
Adenosine monophosphate analog that inhibits reverse transcriptase domain of Hep B DNA polymerase Tenofovir
Interferes with viral mRNA sythesis Ribavirin
Mono P form of Ribavirin inhibits GTP synthesis (inosine-5'-P dehydrogenase)
Tri P form of Ribavirin inhibits GTP dependent capping of viral mRNA
Form Ribavirin used in with _____________disease in infants and young children aerosol; Respiratory syncytial virus
Ribarvirin combined with __________is used to treat Hep C Interferon alpha
Alpha interferon approved for use in ________ & _________ & ______ Hep B; Hep C; Condyloma accuminata
Four types of Nucleoside Inhibitors of Reverse Transcriptase are Zidovudine
Thymidine nucleoside analog that is phosphorylated by cellular kinases. Also acts as a DNA chain terminator Zidovudine
Nucleoside analog inhibitor of reverse transcriptase that has synergistic usage with AZT and few side effects Lamivudine
Nucleotide prodrug that inhibits RT by competing with dATP for incorporation into DNA....resulting in chain termination Tenofovir
Flourinated analog of 3TC, inhibits RT by competing for dCTP incorporation in DNA, causing chain termination Emtricitabine
Non-nucleoside inhibitor of RT is Efavirenz
Two drugs that prevent aspartic protease from cleaving Gag-pol polypeptide into separate functional proteins.....results in non-infectious viral particles. Lopinavir, Ritonavir
Lopinavir and Ritonavir used for... HIV
Binds gp41 subunit of HIV glycoprotien block fusion of virus with CD4+ membranes Enfuvirtide
Enfuvirtide can only be used with this virus strain HIV-1
Chemokine co-receptor (CCR5) antagonist, block HIV entry into cell Maraviroc
Inhibits HIV-1 integrase, preventing integration of HIV DINA into genome Raltegravir
Created by: DocTwiz
Popular Pharmacology sets

 

 



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