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2nd Top 200

BrandGenericScheduleMOAIndicationsC/IADRsBBW
Tylenol/Codeine acetaminophen/codeine C-III (tablet) C-V (liquid) Opioid Analgesic Combination Pain management -Acute/severe bronchial asthma -Postoperative pain management in children after tonsillectomy/adenoidectomy -Significant respiratory depression None Med errors; Addiction, abuse, & misuse; Life-threatening resp depression; Accidental ingestion; Neonatal opioid w/drawal syndrome; Hepatotoxicity; Death related to rapid metabolism of codeine-morphine; 3A4 interactions; Use w/ benzos/other CNS depressants
Humira adalimumab Rx DMARD; TNF Blocking Agent Ankylosing spondylitis Ulcerative colitis Crohn disease Hidradenitis suppurativa Plaque psoriasis Uveitis Psoriatic arthritis RA None -HA -Skin rash -Positive ANA titer -AB development -Injection site reaction -URI, sinusitis -Increased creatine phosphokinase Serious infections; Malignancy
Zyloprim allopurinol Rx Antigout Agent; Xanthine Oxidase Inhibitor Gout Cancer therapy-induced hyperuricemia Calcium oxalate stones (recurrent) None -Skin rash -Gout, acute -Nausea, diarrhea None
Xanax alprazolam C-IV Benzodiazepine Anxiety disorders Panic disorder -Acute narrow-angle glaucoma -Concurrent use with ketoconazole, itraconazole, or other potent CYP3A4 inhibitors -Drowsiness, fatigue, sedation, ataxia, memory impairment, irritability, cognitive dysfunction, dysarthria, DZ, depression -Skin rash -Weight gain/loss, decreased libido -Inc/dec appetite, constipation, xerostomia -Difficulty in micturition Use w/opioids
Elavil amitriptyline Rx TCA; Increases the synaptic concentration of serotonin and/or NE in CNS by inhibition of their reuptake by the presynaptic neuronal membrane pump Depression -W/in 14 days of MAOIs -Cisapride -Acute recovery phase following MI None Suicidality & antidepressant drugs
Adderall, Adderall XR amphetamine salts (XR) C-II CNS Stimulant ADHD Narcolepsy -Advanced arteriosclerosis -Symptomatic CV disease -Moderate-severe HTN -Hyperthyroidism -Glaucoma -Agitated states -Hx of drug abuse -W/in 14 days of MAOI -Systolic HTN -Insomnia, HA -Weight loss -Decreased appetite, xerostomia, abd pain Abuse potential; CV events
Abilify aripiprazole Rx SGA; Partial agonist at D2 & 5-HT1A receptors, & as an antagonist at 5-HT2A receptor Acute agitation (schizophrenia/bipolar mania) Bipolar I disorder (acute manic/mixed episodes) Depression (adjunctive w/antidepressants) Schizophrenia None -HA, extrapyramidal, drowsiness, akathisia, fatigue, sedation, agitation, insomnia, anxiety -Weight gain, increased serum cholesterol/TGs/Glu, decreased HDL, Increased LDL -N/V/C -Tremor Increased mortality in elderly pts w/dementia-related psychosis; Suicidality & antidepressant drugs
Strattera atomoxetine Rx Selective NE Reuptake Inhibitor ADHD -W/in 14 days of MAOIs -Narrow-angle glaucoma -Pheochromocytoma -Severe CV disorders -HA, insomnia, drowsiness -Hyperhidrosis -Xerostomia, nausea, decreased appetite, abd pain, vomiting, constipation -Erectile dysfunction Suicide ideation in children & adolescents
Gablofen, Lioresal baclofen Rx Skeletal Muscle Relaxant Spasticity -Intrathecal: IV, IM, SQ, or epidural admin. -Hypotonia, drowsiness, confusion, HA -N/V Abrupt withdrawal (injection)
Cogentin benztropine Rx Possesses both anticholinergic & antihistaminic effects Drug-induced extrapyramidal symptoms -Acute dystonic reactions Parkinsonism, idiopathic -Postencephalitic -< 3 y/o None None
Suboxone, Bunavail, Zubsolv buprenorphine/naloxone C-III Buprenorphine: high affinity binding to mu opiate receptors in the CNS; displays partial mu agonist & weak kappa antagonist activity Naloxone: pure opioid antagonist that competes and displaces opioids at opioid receptor sites Opioid Dependence None -HA, withdrawal syndrome, pain -Diaphoresis -Glossodynia (film), oral hypoesthesia (film), oral mucosa erythema (film) None
Fiorcet, Esgic butalbital/APAP/caffeine Rx Butalbital: barbiturate Acetaminophen: inhibits the synthesis of prostaglandins in CNS & peripherally blocks pain impulse generation Caffeine: CNS stimulant Tension/muscle contraction HA -Porphyria None Hepatotoxicity
Soma carisoprodol C-IV Skeletal Muscle Relaxant Acute musculoskeletal pain, short-term (2-3 wks) -Hypersensitivity to carbamates -Hx of acute intermittent porphyria -Drowsiness None
Celebrex celecoxib Rx NSAID, COX-2 Selective Acute pain Primary dysmenorrhea Ankylosing spondylitis OA RA Juvenile Idiopathic Arthritis -Hypersensitivity to sulfonamides, ASA, other NSAIDs -Experienced asthma, urticarial, or allergic-type rxns after taking ASA or other NSAIDs -use in CABG surgery None Serious CV risk; Serious GI risk
Celexa citalopram Rx SSRI Depression -W/in 14 days of MAOIs -Linezolid or IV methylene blue -Pimozide -Drowsiness, insomnia -Diaphoresis -Nausea, xerostomia Suicidality & antidepressants
Klonopin clonazepam C-IV Benzodiazepine Panic disorder Seizure disorder -Hypersensitivity to other benzos -Significant liver disease -Acute narrow-angle glaucoma Drowsiness, ataxia, behavioral problems, DZ Use w/opioids
Plavix clopidogrel Rx Antiplatelet Agent; Prodrug irreversibly blocks the P2Y12 component of ADP receptors of plt surface (prevents activation of GPIIb/IIIa receptor complex=↓ plt aggregation) ACS (UA, NSTEMI, STEMI) Recent MI, stroke, or PAD -Active pathological bleeding (peptic ulcer, intracranial hemorrhage) None Diminished antiplatelet effect in pts w/ 2 loss-of-function alleles in CYP2C19 gene
Colcrys colchicine Rx Antigout Agent; Disrupts cytoskeletal functions by inhibiting beta-tubulin polymerization into microtubules, preventing activation, degranulation & migration of neutrophils associated w/mediating some gout symptoms Familial Mediterranean fever (FMF) Gout: -Flare -Px -Use of P-gp or strong CYP3A4 inhibitor w/ renal/hepatic impairment -GI disease, diarrhea, vomiting, nausea None
Flexeril, Amrix cyclobenzaprine Rx Centrally-acting skeletal muscle relaxant pharmacologically related to TCAs; reduces tonic somatic motor activity influencing both alpha and gamma motor neurons Muscle spasm -W/in 14 days of MAOI -Hyperthyroidism -HF, arrhythmias, heart block or conduction disturbances -Acute recovery phase of MI -Drowsiness, DZ -Xerostomia None
Pristiq desvenlafaxine Rx SNRI Depression -W/in 14 days of MAOI -Linezolid, IV methylene blue -DZ, insomnia -Hyperhidrosis -Nausea, xerostomia Suicidal thoughts & behavior
Focalin XR dexmethylphenidate C-II CNS Stimulant; More active form of methylphenidate; blocks reuptake of NE & DA, & increases their release into the extraneuronal space ADHD -Marked anxiety, tension, agitation -Glaucoma -Motor tics, Tourette syndrome -W/in 14 days of MAOI -HA, insomnia, restlessness, anxiety -Decreased appetite, xerostomia, abd pain Drug dependence
Valium diazepam C-IV Benzodiazepine; Binds to stereospecific benzo receptors on postsynaptic GABA neuron at several sites w/in CNS leading to increased permeability to Cl- and hyperpolarization Acute EtOH withdrawal Anxiety Muscle spasm Preoperative anxiety Seizures Status epilepticus Skeletal muscle relaxant (adjunct) -Acute narrow-angle glaucoma, untreated open-angle glaucoma -< 6M (oral) -Myasthenia gravis -Severe respiratory impairment -Severe hepatic impairment -Sleep apnea syndrome (oral tab) None None
Voltaren Gel diclofenac Rx NSAID, topical OA -Hx of asthma, urticarial, or other allergic-type rxns after taking ASA or other NSAIDs -Use in CABG surgery -Pruritus, application site rash, contact dermatitis, xeroderma, application site pain, desquamation -Increased serum transaminases Serious CV thrombotic events; Serious GI bleeding, ulceration, & perforation
Depakote divalproex Rx Increases availability of GABA to brain neurons or may enhance action of GABA or mimic its action at postsynaptic receptor sites Seizures Mania Migraine Px -Hepatic disease -Urea cycle disorders -Pregnant women for migraine Px -Mitochondrial disorders -HA, drowsiness, DZ, insomnia, nervousness -Alopecia -N/V/D, dyspepsia, abd pain, anorexia -Thrombocytopenia, infection -Tremor, weakness -Diplopia, visual disturbances -Flu-like symptoms Hepatotoxicity; Pt w/mitochondrial disease; Fetal risk; Pancreatitis
Lexapro escitalopram Rx SSRI MDD GAD -W/in 14 days of MAOI -Linezolid, IV methylene blue -Pimozide -HA, insomnia, drowsiness -Nausea, diarrhea -Ejaculatory disorder Suicidality & antidepressant drugs
Lunesta eszopiclone C-IV Hypnotic; May interact w/GABA-receptor complexes at binding domains located close to or allosterically coupled to benzo receptors Insomnia None -HA -Dysgeusia None
Enbrel etanercept Rx DMARD; TNF Blocking Agent Ankylosing spondylitis Psoriatic arthritis RA Plaque psoriasis Polyarticular juvenile idiopathic arthritis -Sepsis -HA -Skin rash -Abd pain, diarrhea, vomiting -Infection -Injection site rxn -RTI, rhinitis -Ab development, positive ANA titer Serious infections; Malignancies
Duragesic fentanyl transderm C-II Increases pain threshold, alters pain reception, inhibits ascending pain pathway in CNS Chronic pain -Severe respiratory disease, acute asthma -Paralytic ileus -Acute/intermittent pain, short-term therapy, postoperative/mild pain -Pts NOT opioid tolerant -Confusion, DZ, drowsiness, fatigue, HA, sedation -Dehydration -N/V/C -Weakness -Dyspnea Addiction, abuse, & misuse; Life-threatening resp depression; Accidental exposure; Neonatal opioid w/drawal syndrome; CYP3A4 interaction; Exposure to heat
Prozac, Sarafem fluoxetine Rx SSRI MDD OCD Bulimia nervosa Panic disorder PMDD -W/in 14 days of MAOI -Linezolid, IV methylene blue -Pimozide, thioridazine -Insomnia, HA, drowsiness, anxiety, nervousness, yawning -Decreased libido -Nausea, diarrhea, anorexia, xerostomia -Weakness, tremor -Pharyngitis Suicidality & antidepressant drugs
Folic acid folic acid Rx Necessary for formation of purine & pyrimidine synthesis, required for nucleoprotein synthesis & maintenance in erythropoiesis, stimulates WBC & plt production in folate deficiency anemia Megaloblastic & macrocytic anemias None None None
Hycet, Lorcet, Lortab, Norco, Verdrocet, Vicodin, Zamicet hydrocodone/APAP C-II Opioid Analgesic Combination Pain management -CNS depression -Severe respiratory depression None Hepatotoxicity
Lamictal lamotrigine Rx Triazine derivative which inhibits release of glutamate (excitatory) & inhibits voltage-sensitive Na+ channels, which stabilizes neuronal membranes Bipolar I disorder (IR only) Epilepsy None -Nausea Serious skin rashes
Xalatan latanoprost Rx Prostaglandin F2-alpha analog; increase outflow of aqueous humor Elevated IOP None -Foreign body sensation of eye -Epithelial keratopathy None
Vyvanse lisdexamfetamine dimesylate C-II CNS Stimulant; Prodrug for dextroamphetamine, a sympathomimetic amine that causes release of DA & NE from storage site in presynaptic nerve terminals ADHD Binge eating disorder -W/in 14 days of MAOI -Insomnia -Decreased appetite, xerostomia, upper abd pain Abuse & dependence
Ativan lorazepam C-IV Benzodiazepine; Binds to stereospecific benzo receptors on postsynaptic GABA neuron at several sites w/in CNS leading to increased permeability to Cl- and hyperpolarization Anxiety disorder Insomnia due to anxiety/stress Premedication for anesthesia Status epilepticus -Hypersensitivity to other benzos -Acute narrow-angle glaucoma -Sleep apnea (parenteral) -Intra-arterial injection of parenteral formulation -Severe respiratory insufficiency None None
Rheumatrex methotrexate Rx DMARD; Antimetabolite (Antifolate) Acute lymphoblastic leukemia (ALL) Breast cancer Choriocarcinoma Chorioadenoma Gestational trophoblastic diseases Head & neck cancer Lymphoma, non-Hodgkin Mycosis fungoides Osteosarcoma Psoriasis RA -Breast-feeding For psoriasis or RA: -Pregnancy -Alcoholism -Alcoholic liver disease, chronic liver disease -Immunodeficiency syndromes -Blood dyscrasias None IT & high-dose therapy; Appropriate use; Pregnancy; Bone marrow suppression; Renal impairment; Hepatotox; Pneumonitis; GI toxici; 2° malignancy; Tumor lysis syndrome; Dermatologic tox; Opportunistic infections; Radiotherapy; Experienced physician (inj)
Medrol methylprednisolone Rx Corticosteroid, Systemic Allergic conditions Anti-inflammatory or immunosuppressive Asthma -exacerbations -maintenance MS, acute exacerbation -Systemic fungal infection -IT administration -Live/attenuated virus vaccines -Use in premature infants None None
Nasonex, Asmanex mometasone Rx Corticosteroid Oral: Asthma Nasal: Allergic rhinitis, Nasal congestion associated w/seasonal rhinitis, Nasal polyps, Px seasonal allergic rhinitis -Hypersensitivity to milk proteins (Twisthaler only) -Primary Tx of status asthmaticus or other acute episodes of asthma for which intensive measures are required -HA, fatigue, depression -Oral candidiasis -Pain, arthralgia -Sinusitis, allergic rhinitis, URTI, pharyngitis, cough, epistaxis -Viral infection None
Singulair montelukast Rx Leukotriene Receptor Antagonist Allergic rhinitis (perennial or seasonal) Asthma Exercise-induced Bronchoconstriction None -HA None
Dilantin phenytoin Rx Stabilizes neuronal membranes & decreases seizure activity by increasing efflux or decreasing influx of Na+ across cell membranes in motor cortex during generation of nerve impulses Status epilepticus Anticonvulsant -Hypersensitivity to other hydantoins -Delvirdine -IV only: Sinus bradycardia, sinoatrial block, second- & third-degree heart block, Adams-Stokes syndrome None CV risk associated w/rapid infusion (injection)
Pravachol pravastatin Rx HMG-CoA Reductase Inhibitor Hyperlipidemia Primary Px of coronary events Secondary Px of CV events -Active liver disease, unexplained persistent elevations of serum transaminases -Pregnancy, breast-feeding None None
Lyrica pregabalin C-V Inhibit excitatory NT release by modulating Ca2+ influx at voltage gated Ca2+ channels in CNS nerve terminals Fibromyalgia Neuropathic pain Partial-onset seizures Postherpetic neuralgia None -Peripheral edema -DZ, somnolence, ataxia, HA, fatigue -Weight gain -Xerostomia -Infection -Tremor -Blurred vision, diplopia -Accidental injury None
Inderal propranolol Rx Beta-Blocker, nonselective Essential tremor HTN Migraine Px Obstructive hypertrophic cardiomyopathy Pheochromocytoma Post-MI mortality reduction Stable angina Tachyarrhythmias -Hypersensitivity to beta-blockers -Uncompensated CHF, cardiogenic shock, severe sinus bradycardia, sick sinus syndrome, or heart block (>1st-degree) -Bronchial asthma None Cardiac ischemia after abrupt discontinuation (Inderal LA & XL)
Crestor rosuvastatin Rx HMG-CoA Reductase Inhibitor Familial hypercholesterolemia Hyperlipidemia & mixed dyslipidemia Hypertriglyceridemia Primary dysbetalipoproteinemia Px of CV disease -Active liver disease, unexplained persistent elevations of serum transaminases -Pregnancy, breast-feeding -Myalgia None
Zocor simvastatin Rx HMG-CoA Reductase Inhibitor Hyperlipidemia Secondary Px of CV disease -Active liver disease, unexplained persistent elevations of serum transaminases -Strong CYP3A4 inhibitors -Cyclosporine, danazol, gemfibrozil -Pregnancy, breast-feeding None None
Vytorin simvastatin/ezetimibe Rx HMG-CoA Reductase Inhibitor & Inhibits absorption of cholesterol at brush border of small intestine (via NPC1L1) Homozygous familial hypercholesterolemia Primary hyperlipidemia Primary & secondary Px of CV disease -Active liver disease, unexplained persistent elevations of serum transaminases -Strong CYP3A4 inhibitors -Cyclosporine, danazol, gemfibrozil -Pregnancy, breast-feeding None None
Timoptic, Timoptic XE timolol (XE) Rx Beta-Blocker, nonselective Elevated IOP -Bronchial asthma (or Hx), Severe COPD -Sinus bradycardia, 2nd- or 3rd-degree AV block, Overt cardiac failure, Cardiogenic shock -Burning sensation of eyes, stinging of eyes None
Travatan Z travoprost Rx Selective FP prostanoid receptor agonist; Increase trabecular meshwork & outflow Elevated IOP None -Ocular hyperemia None
Dyazide, Maxzide triamterene/hydrochlorothiazide Rx K+ Sparing Diuretic & Thiazide Diuretic HTN Edema -Hypersensitivity to sulfonamides -Anuria, acute & chronic renal insufficiency, significant renal impairment -K+ sparing diuretics, K+ containing salt substitutes, or K+ supplements (except in severe cases of hypokalemia) -Preexisting hyperkalemia None Hyperkalemia
Depakene valproic acid Rx Increases availability of GABA to brain neurons or may enhance action of GABA or mimic its action at postsynaptic receptor sites Seizures -Hepatic disease -Urea cycle disorders -Pregnant women for migraine Px -Mitochondrial disorders -HA, drowsiness, DZ, insomnia, nervousness -Alopecia -N/V/D, dyspepsia, abd pain, anorexia -Thrombocytopenia, infection -Tremor, weakness -Diplopia, visual disturbances -Flu-like symptoms Hepatotoxicity; Pts w/mitochondrial disease; Fetal risk; Pancreatitis
Created by: kcapizzi