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Pharm Unit 13

SPC Pharmacology Unit 13 Exam 5

What is the purpose of a Mucolytic? Breaks down mucus
What is mucus? a chain of amino sugars and amino acids linked together by disulfide bonds 95% water carbohydrates, lipids, glycoproteins
Mucolytic may promote what in asthmatics? Severe bronchospasm in asthmatics
Mucolytic short term or long term use? Short term 3-5 days then re-evaluate to determine need.
Mucomyst is an Antioxidant free radical scavenger
What should be done after use of Mucomyst? Rinse mouth after each use
What in more detail is the purpose of Mucomyst? Lysis (disrupts) disulfide bonds Lowers mucus viscosity and elasticity
Why cant mucomyst be given to nauseated patients? it smells and may promote nausea and vomiting
Allergy history to sulfides/sulfur is? Not a contraindication to inhalation of mucomyst (n-acetylcysteine)
Mucomyst is compatible with? Sympathomimetics
Mucomyst is not compatible with? Antibiotics
What solutions are available to a mucolytic? 10% and 20%
Which is recommended 10% or 20% solution? 10% is recommended because it has a lesser incidence of side effects and clinically equally effective
Dornase Alfa also known as? Pulmozyme
Pulmozyme thins infectious mucus by disrupting the DNA bonds found in infectious mucus which makes it very vicous
HCA (Health Care Worker) should.... Avoid inhalation during administration due to effects of DNA
How long can Pulomzyme be at room temperature? No more than 24hrs or throw away
Pulmozyme ampoule must be... Clear and Refrigerated.
When should Pulmozyme be administered? Immediately after opening
T/F Pulmozyme should be administered in a dedicated nebulizer? True
Don't breath it, administer it Pulmozyme
Avoid if patient is on sodium restrictions or has metabolic alkalosis. Sodium Bicarbonate
Sodium Bicarbonate is a? Benign Mucolytic
Sodium Bicarbonate is administered by? Instillation or Nebulization
Isotonic 0.9%
Hypotonic <0.9% Incidence of airway irritation is significantly less than other solutions
Hypertonic >0.9% Promotes cough, may cause bronchospasm
Potassium Iodide (SSKI) Reduces mucus elasticity and has a direct mucolytic effect
Surface Tension Opposes Inspiration Opposed Alveolar Expansion Reduces stability of alveolus The force that resists the inflation of the alveolus (lung cant inflate)
Surfacant Is a complex mixture of lipids and proteins produced by Type II cells. (Reduces surface tension) Lowers Surface tension so lung can inflate
Natural Surfactants Potential Viral Infection Expensive Time Consuming to Prepare
Synthetic Surfactants Free potential infectious agents Reduced Efficacy (response) Less costly Easy to Acquire
Dosing of Surfactants Direct Instillation
Hazards of instillation of Surfactants Airways obstruction Bradycardia Desaturation
The Surfactant Layer does what? Promotes homogenous gel layer Prevents water loss from sol layer
Where is the surfactant layer? Between the gel and the sol layer
Adverse reactions to Pulmozyme.... Chest pain, irritation/inflammation of the eye, mouth, laryngitis
The goal of Surfactants Reduce surface tension Promote lung inflation
Created by: Langhout1418