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APhA Drugs Review
Brand, Generic, MOA, Indication
| Brand | Generic | MOA | Dose Frequency | Formulations | Indications | AE, SE, or Black Box |
|---|---|---|---|---|---|---|
| Naturetin | Bendroflumethiazide | Thiazide Diuretic | Once Daily | PO | HTN | Inc Cholesterol, Glucose, Uric Acid, Calcium. Dec K+, Na+, Mg2+. Blood Dyscrasias, Photosensitivity, Pancreatitis, Sulfa-Rxn, Impotence, Fatigue, HA, Rash, Vertigo |
| Aquatag, Exna | Benzithiazide | Thiazide Diuretic | Once Daily | PO | HTN | Inc Cholesterol, Glucose, Uric Acid, Calcium. Dec K+, Na+, Mg2+. Blood Dyscrasias, Photosensitivity, Pancreatitis, Sulfa-Rxn, Impotence, Fatigue, HA, Rash, Vertigo |
| Diuril | Chlorothiazide | Thiazide Diuretic | Once Daily | PO | HTN | Inc Cholesterol, Glucose, Uric Acid, Calcium. Dec K+, Na+, Mg2+. Blood Dyscrasias, Photosensitivity, Pancreatitis, Sulfa-Rxn, Impotence, Fatigue, HA, Rash, Vertigo |
| Hygroton, Hylidone | Chlorthalidone | Thiazide Diuretic | Once Daily | PO | HTN | Inc Cholesterol, Glucose, Uric Acid, Calcium. Dec K+, Na+, Mg2+. Blood Dyscrasias, Photosensitivity, Pancreatitis, Sulfa-Rxn, Impotence, Fatigue, HA, Rash, Vertigo |
| HydroDIURIL, Microzide | HCTZ | Thiazide Diuretic | Once Daily | PO | HTN, CHF Edema, Hepatic Cirrhosis, Renal Dysfxn, Steroid/Estrogen Therapy | Inc Cholesterol, Glucose, Uric Acid, Calcium. Dec K+, Na+, Mg2+. Blood Dyscrasias, Photosensitivity, Pancreatitis, Sulfa-Rxn, Impotence, Fatigue, HA, Rash, Vertigo |
| Saluron, Diucardin | Hydroflumethiazide | Thiazide Diuretic | Once Daily | PO | HTN | Inc Cholesterol, Glucose, Uric Acid, Calcium. Dec K+, Na+, Mg2+. Blood Dyscrasias, Photosensitivity, Pancreatitis, Sulfa-Rxn, Impotence, Fatigue, HA, Rash, Vertigo |
| Renese | Polythiazide | Thiazide Diuretic | Once Daily | PO | HTN | Inc Cholesterol, Glucose, Uric Acid, Calcium. Dec K+, Na+, Mg2+. Blood Dyscrasias, Photosensitivity, Pancreatitis, Sulfa-Rxn, Impotence, Fatigue, HA, Rash, Vertigo |
| Metahydrin, Naqua | Trichlormethiazide | Thiazide Diuretic | Once Daily | PO | HTN | Inc Cholesterol, Glucose, Uric Acid, Calcium. Dec K+, Na+, Mg2+. Blood Dyscrasias, Photosensitivity, Pancreatitis, Sulfa-Rxn, Impotence, Fatigue, HA, Rash, Vertigo |
| Mykrox, Zaroxolyn | Metolazone | Thiazide-like Diuretic | Once Daily | PO | HTN, CHF Edema, Renal Dysfxn | Less/No Hypercholesterolemia |
| Lozol | Indapamide | Thiazide-like Diuretic | Once Daily | PO | HTN, CHF Edema | Less/No Hypercholesterolemia |
| Bumex | Bumetanide | Loop Diuretic | Once to BID | PO, IM, IV | CHF Edema, Cirrhosis, Renal Disease, HTN | Ototoxicity at high doses |
| Lasix | Furosemide | Loop Diuretic | Once to BID | PO, Soln, IV, IM | CHF Edema, Cirrhosis, Liver & Renal Disease, HTN, Pulmonary Edema | Ototoxicity at high doses |
| Demadex | Torsemide | Loop Diuretic | Once Daily | PO, IV | CHF & Chronic Renal Failure Edema, Hepatic Cirrhosis, HTN | Ototoxicity at high doses |
| Midamor | Amiloride | K+ Sparing Agent | Once to BID | PO | HTN | Hyperkalemia |
| Dyrenium | Triamterene | K+ Sparing Agent | Once to BID | PO | HTN | Avoid w/hx of Kidney Stones or Hepatic Disease |
| Aldactone | Spironolactone | Aldosterone Antagonist | Once to BID | PO | CHF Edema, Cirrhosis w/Edema &/or Ascites, HTN, Hypokalemia, Primary Hyperaldosteronism | Diarrhea, Drowsiness, HA, Amenorrhea, Weakness, Parethesia, Mental Confusion, Dry Mouth, Muscle Cramps, Hirsutism,Urticaria, Impotence, Gynecomastia, N/V, Angioedema, Hyperkalemia |
| Lotrel | Amlodipine & Benazepril | CCB & ACEI | Once Daily | PO | HTN | |
| Lexxel | Enalapril & Felodipine | ACEI & CCB | Once Daily | PO | HTN | |
| Tarka | Trandolapril & Verapamil | ACEI & CCB | Once Daily | PO | HTN | |
| Lotensin HCT | Benazepril & HCTZ | ACEI & Thiazide Diuretic | Once Daily | PO | HTN | |
| Capozide | Captopril & HCTZ | ACEI & Thiazide Diuretic | Once Daily | PO | HTN | |
| Vaseretic | Enalapril & HCTZ | ACEI & Thiazide Diuretic | Once Daily | PO | HTN | |
| Prinzide | Lisinopril & HCTZ | ACEI & Thiazide Diuretic | Once Daily | PO | HTN | |
| Uniretic | Moexipril & HCTZ | ACEI & Thiazide Diuretic | Once Daily | PO | HTN | |
| Accuretic | Quinapril & HCTZ | ACEI & Thiazide Diuretic | Once Daily | PO | HTN | |
| Atacand HCT | Candesartan & HCTZ | ARB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Teveten | Eprosartan & HCTZ | ARB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Avalide | Irbesartan & HCTZ | ARB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Hyzaar | Losartan & HCTZ | ARB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Micardis HCT | Telmisartan & HCTZ | ARB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Diovan HCT | Valsartn & HCTZ | ARB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Tenoretic | Atenolol & Chlorthalidone | BB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Ziac | Bisoprolol & HCTZ | BB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Inderide | Propanolol LA & HCTZ | BB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Lopressor HCT | Metoprolol tartate & HCTZ | BB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Corzide | Nadolol & Bendrofluthiazide | BB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Timolide | Timolol & HCTZ | BB & Thiazide Diuretic | Once Daily | PO | HTN | |
| Alodril | Methyldopa & HCTZ | Centrally Acting a2-Agonist | Once Daily | PO | HTN | |
| Diupres | Reserpine & Chlorthiazide | Centrally Acting a2-Agonist & Thiazide Diuretic | Once Daily | PO | HTN | |
| Hydropres | Reseroine & HCTZ | Centrally Acting a2-Agonist & Thiazide Diuretic | Once Daily | PO | HTN | |
| Moduretic | Amiloride & HCTZ | K+ Sparing & Thiazide Diuretic | Once Daily | PO | HTN | |
| Aldactone | Spironolactone & HCTZ | Aldosterone Antagonist & Thiazide Diuretic | Once Daily | PO | HTN | |
| Dyazide, Maxzide | Triamterene & HCTZ | K+ Sparing & Thiazide Diuretic | Once to BID | PO | HTN, CHF Edema, Cirrhosis,Nephrotic Syndrome, Steroid/Estrogen Edema | |
| Ismelin | Guanethidine | AdrenergicInhibitor (peripheral a2-agonist, inhibiting release of neurotransmitter) | Once Daily | PO | Refractory HTN | Postural hypotension, Diarrhea |
| Serpasil | Reserpine | AdrenergicInhibitor (peripheral a2-agonist, inhibiting release of neurotransmitter) | Once Daily | PO | Refractory HTN | Depression, PUD Activation, Nasal Congestion, Sedation, Dizziness, Lethargy, Memory Impairment, Sleep Disturbances, Weight Gain |
| Catapres | Clonidine | Centrally Acting a2-Agonist | BID | PO, Transdermal | HTN | Most Withdrawal HTN, Sedation Dry Mouth, Bradycardia, Orthostatic, Hypotension, Depression, Impotence, Sleep Disturbances |
| Wytensin | Guanabenz | Centrally Acting a2-Agonist | BID | PO | HTN | Withdrawal HTN, Sedation Dry Mouth, Bradycardia, Orthostatic Hypotension, Depression, Impotence, Sleep Disturbances |
| Tenex | Guanfacine | Centrally Acting a2-Agonist | Once Daily | PO | HTN | Least Withdrawal HTN, Sedation Dry Mouth, Bradycardia, Orthostatic Hypotension, Depression, Impotence, Sleep Disturbances |
| Aldomet | Methyldopa | Centrally Acting a2-Agonist | BID | PO | HTN | Hepatic & AutoimmuneDisorders,Withdrawal HTN, Sedation Dry Mouth, Bradycardia, Orthostatic Hypotension, Depression, Impotence, Sleep Disturbances |
| Cardura, XL | Doxazosin | Peripherally Acting a1-Blocker | Once Daily | PO | HTN, BPH | Take XL In AM w/Breakfast. Postural Hypotension, Syncopal Episode w/1st Dose, Diarrhea, Weight Gain, Peripheral Edema, Dry Mouth, Urinary Urgency, Constipation, Priapism, Nausea, Dizziness, HA, Palpitations, Sweating. No Effects on Glucose or Cholesterol. |
| Minipress | Prazosin | Peripherally Acting a1-Blocker | BID to TID | PO | HTN, BPH | Postural Hypotension, Syncopal Episode w/1st Dose, Diarrhea, Weight Gain, Peripheral Edema, Dry Mouth, Urinary Urgency, Constipation, Priapism, Nausea, Dizziness, HA, Palpitations, Sweating. No Effects on Glucose or Cholesterol. |
| Hytrin | Terazosin | Peripherally Acting a1-Blocker | Once to BID | PO | HTN, BPH | Postural Hypotension, Syncopal Episode w/1st Dose, Diarrhea, Weight Gain, Peripheral Edema, Dry Mouth, Urinary Urgency, Constipation, Priapism, Nausea, Dizziness, HA, Palpitations, Sweating. No Effects on Glucose or Cholesterol. |
| Sectral | Acebutolol | Cardioselective BB, Intrinsic Sympathomimetic Activity, Hepatic Elimination, Low Lipid Solubility | Once Daily | PO | HTN | Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired Peripheral Circulation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Tenormin | Atenolol | Cardioselective BB, Renal Elimination, Low Lipid Solubility | Once Daily | PO, IV | HTN, Angina, AMI | HyperTG, Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired Peripheral Circulation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Kerlone | Betaxolol | Cardioselective BB, Hepatic Elimination, Low Lipid Solubility | Once Daily | PO | HTN | HyperTG, Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired Peripheral Circulation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Zebeta | Bisoprolol | Cardioselective BB, Renal Elimination, Low Lipid Solubility | Once to BID | PO | HTN, CHF | HyperTG, Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired Peripheral Circulation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Cartrol | Carteolol | Non-Selective BB, Renal Elimination, Low Lipid Solubility | Once Daily | PO | HTN | HyperTG, Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired Peripheral Circulation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Lopressor | Metoprolol tartate | Cardioselective BB, Hepatic Eliminaton, Moderate Lipid Solubility | BID | PO, IV | HTN | Take w/Food, HyperTG, Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired PeripheralCirculation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Toprol-XL | Metoprolol succinate | Cardioselective BB, Hepatic Elimination, Moderate Lipid Solubility | Once Daily | PO | HTN, CHF, Angina | Take w/Food, HyperTG, Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired PeripheralCirculation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Corgard | Nadolol | Non-Selective BB, Renal Elimination, Low Lipid Solubility | Once Daily | PO | HTN | HyperTG, Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired PeripheralCirculation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Levatol | Penbutolol | Non-Selective BB, Intrinsic Sympathomimetic Activity, Hepatic Elimination, High Lipid Solubility | Once Daily | PO | HTN | Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired Peripheral Circulation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Visken | Pindolol | Non-Selective BB, Intrinsic Sympathomimetic Activity, Hepatic Elimination, Moderate Lipid Solubility | BID | PO | HTN | Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired Peripheral Circulation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Inderal, LA | Propanolol | Non-Selective BB, Hepatic Elimination, High Lipid Solubility | BID, Daily | PO, IV | HTN, Arrythmias, Angina, Migraine, MI, Pheochromocytoma, Preoperatively, Anesthesia | HyperTG, Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired Peripheral Circulation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Blocadren | Timolol | Non-Selective BB, Hepatic Elimination, Low-Mod Lipid Solubility | BID | PO | HTN | HyperTG, Bronchospasm, Bradycardia, HF, Mask Hypoglycemia, Impaired Peripheral Circulation, Insomnia, Fatigue, Decreased Exercise Tolerance |
| Coreg, CR | Carvedilol | Combined a & b Blocker, Bile into Feces, Moderate Lipid Solubility | BID, Daily | PO | HTN, CHF, LV Dysfxn following MI | Take w/Food, Postural Hypotension, Broncospasm |
| Normodyne, Trandate | Labetalol | Combined a & b Blocker, Renal Elimination, Moderate Lipid Solubility | BID | PO | HTN | Postural Hypotension, Broncospasm |
| Apresoline | Hydralazine | Direct Vasodilator | BID to QID | PO, IM, IV | Refractory HTN | Lupus Syndrome, Must Use w/Diuretic (Edema) & BB (Tachycardia), HA, PeripheralNeuropathy, Postural HTN |
| Loniten | Minoxidil | Direct Vasodilator | Daily to BID | PO | Refractory HTN | Hirsutism, Must Use w/Diuretic (Edema) & BB (Tachycardia), HA, Peripheral Neuropathy, Postural HTN |
| Cardizem SR, CD, Dilacor XR, Tiazac | Diltiazem | Non-Dihydro CCB | Once Daily | PO, IV | HTN, Angina, A Fib or Flutter | Take on Empty Stomach, Nausea, HA, Conduction Defects, Worsening of Systolic Dysfxn, Gingival Hyperplasia |
| Calan, Isoptin | Verapamil IR | Non-Dihydro CCB | BID | PO, IV | Angina, Arrhythmias | Take on Empty Stomach, Conduction Defects, Worsening of Systolic Dysfxn, Gingival Hyperplasia |
| Calan SR, Isoptin SR | Verapamil Long-Acting | Non-Dihrdro CCB | Once to BID | PO | HTN | Take on Empty Stomach, Constipation, Conduction Defects, Worsening of Systolic Dysfxn, Gingival Hyperplasia |
| Covera HS, Verelan PM | Verapamil-Coer | Non-Dihydro CCB | Once Daily | PO, IV | Angina, Arrhythmias | Take On Empty Stomach, Conduction Defects, Worsening of Systolic Dysfxn, Gingival Hyperplasia |
| Norvasc | Amlodipine | Dihydro CCB | Once Daily | PO | HTN | Edema of Ankle, Flushing, HA, Gingival Hyperplasia |
| Plendil | Felodipine (ER) | Dihydro CCB | Once Daily | PO | HTN | Elderly/Hepatic Impairment 10mg Max, Edema of Ankle, Flushing, HA, Gingival Hyperplasia |
| DynaCirc, CR | Isradipine | Dihydro CCB | BID, Once | PO | HTN | Edema of Ankle, Flushing, HA, Gingival Hyperplasia |
| Cardene SR | Nicardipine | Dihydro CCB | Once Daily | PO | HTN | Edema of Ankle, Flushing, HA, Gingival Hyperplasia |
| Procardia, XL, Nifedical XL, Adalat CC | Nifedipine | Dihydro CCB | TID to QID, Once | PO | HTN, Angina | Take on Empty Stomach, Edema of Ankle, Flushing, HA, Gingival Hyperplasia |
| Sular | Nisoldipine | Dihydro CCB | Once Daily | PO | HTN | Edema of Ankle, Flushing, HA, Gingival Hyperplasia |
| Lotensin | Benazepril | ACEI | Once to BID | PO | HTN | Renal Dose, Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Capoten | Captopril | ACEI | BID to TID | PO | HTN, CHF, Nephropathy, Post MI | Take on Empty Stomach, Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Vasotec | Enalapril | ACEI | Once to BID | PO, IV | HTN, CHF, LV Dysfxn | Renal Dose, Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Monopril | Fosinopril | ACEI | Once to BID | PO | HTN, CHF | Avoid Antacids, Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Prinivil, Zestril | Lisinopril | ACEI | Once Daily | PO | HTN, CHF, Post MI | Renal Dose, Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Univasc | Moexipril | ACEI | Once Daily | PO | HTN | Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Aceon | Perindopril | ACEI | Once to BID | PO | HTN | Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Accupril | Quinapril | ACEI | Once to BID | PO | HTN, CHF | Renal Dose, Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Altace | Ramipril | ACEI | Once to BID | PO | HTN, CHF, Post MI | Renal Dose, Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Mavik | Trandolapri | ACEI | Once Daily | PO | HTN, CHF | Cough, Vertigo, HA, Fatigue, 1st Dose Hypotension, GI Disturbances, Acute Renal Insufficieny, Andioedema, Hyperkalemia, Rash, Loss of Taste, Leukopenia |
| Atacand | Candesartan | ARB | Once Daily | PO | HTN, CHF | Angioedema, Hyperkalemia |
| Teveten | Eprosartan | ARB | Once to BID | PO | HTN, Nephropathy | Angioedema, Hyperkalemia |
| Avapro | Irbesartan | ARB | Once Daily | PO | HTN | Angioedema, Hyperkalemia |
| Cozaar | Losartan | ARB | Once to BID | PO | HTN, Nephropathy, LV Hypertropht | Angioedema, Hyperkalemia |
| Benicar | Olmesartan | ARB | Once Daily | PO | HTN | Angioedema, Hyperkalemia |
| Micardis | Telmisartan | ARB | Once Daily | PO | HTN | Angioedema, Hyperkalemia |
| Diovan | Valsartan | ARB | Once to BID | PO | HTN, CHF, Post MI | Angioedema, Hyperkalemia |
| Benicar HCT | Olmesartan & HCTZ | ACEI & Thiazide Diuretic | Once Daily | PO | HTN | |
| Inspra | Eplerenone | Aldosterone Antagonist | Once Daily | PO | CHF | Hyperkalemia, CYP3A4 Substrate, Irregular menses, SrCr <2.5 (men) & 2.0 (women), and K+<5 to start. |
| Lanoxin, Lanoxicaps, Digitek | Digoxin | Inhibits Na+,K+,ATPase pump (inc intracellular Ca2+). Positive Inotropic Effect. | Once Daily | Tablets (0.65 BA), Elixir (0.8 BA), Capsules (0.95 BA) | CHF, A Fib & Flutter, Atrial Tachycardia | Renally Eliminated, Dose to Weight & Elderly, HypoK+ Leads To Toxicity, Anorexia, N/V, Gynecomastia, Blurred Vision, HA, Bradycardia |
| Synthroid, Levothroid, Levoxyl, Unithroid, Thyro-Tabs | Levothyoxine | T4, Enhance Oxygen Consumption & Inc Basal Metabolic Rate & Metabolism of Carbs Lipids & Proteins | Once Daily | PO, IV (Dose Reduced 25-50%) | Hypothyroidism, Myxedema | Overdose Hypermetabolic States: Fever, Hypoglycemia, HF, Fluid Loss, Tachycardia, Anxiety, Insomnia, Avoid Antacids, Ca2+, Fe3+ w/In 4h, Take On Empty Stomach |
| Armour Thyroid, Nature Throid, Westhroid | Dessicated Thyroid | Enhance Oxygen Consumption & Inc Basal Metabolic Rate & Metabolism of Carbs Lipids & Proteins | Once Daily | PO | Hypothyroidism | Overdosage: Weight Loss, Palpitation, Nervousness, Diarrhea, Abd Cramps, Sweating, Tachy, Angina, HA, Insomnia, Heat Intolerance |
| Cytomel, Triostat | Liothyronine | T3, Enhance Oxygen Consumption & Inc Basal Metabolic Rate & Metabolism of Carbs Lipids & Proteins | Once Daily | PO, IV (Dose Reduced 25-50%) | Hypothyroidism, Myxedema | Overdosage: Weight Loss, Palpitation, Nervousness, Diarrhea, Abd Cramps, Sweating, Tachy, Angina, HA, Insomnia, Heat Intolerance |
| Thyrolar | Liotrix | T4 & T3 (4:1 Ratio), Enhance Oxygen Consumption & Inc Basal Metabolic Rate & Metabolism of Carbs Lipids & Proteins | Once Daily | PO | Hypothroidism | Overdosage: Weight Loss, Palpitation, Nervousness, Diarrhea, Abd Cramps, Sweating, Tachy, Angina, HA, Insomnia, Heat Intolerance |
| PTU | Propylthiouracil | Inhibits Thyroid Hormone Synthesis, Prevents Iodine into Iodotyosines & Coupling. Inhibits Peripheral Conversion of T4 to T3 | TID (q8h) | PO | Hyperthyroidism | Fever, HA, Rash, Arthalgia, Urticaria, Jaundice, Hepatitis, Agranulocytosis, Leukopenia, Bleeding |
| Tapazole | Methimaxole | Inhibits Thyroid Hormone Synthesis | Once Daily | PO | Hyperthyroidism | Fever, HA, Rash, Arthalgia, Urticaria, Jaundice, Hepatitis, Agranulocytosis, Leukopenia, Bleeding |
| Lugol's Soln, SSKI | Strong Iodine Soln, Saturated Soln of Potassium Iodide | Block Hormone Release, Inhibit Thyroid Hormone Synthesis | TID w/Juice or H2O | PO | Thyroid Storm, Dec Glandular Vascularity Prior to Thyroidectomy, Rapid Reduction in Hormones | Rash, Swelling of Salivary Glands, Metallic Taste, Burning of MOuth, GI Distress, Hypersensitivity, Goiter |
| Nizoral | Ketoconazole | Inhibits CYP450 Dependent Enzymes | Once Daily | PO | Cushing's Disease | DDI (CYP3A4 Inhibitor), Avoid Drugs That Lower Gastric Acidity By At Least 2h, Take w/Food, N/V, HA, Impotence, Hepatotoxicity |
| Cytadren | Aminoglutethimide | Inhibits Conversion of Cholesterol to Pregnenolone | QID (q6h) | PO | Cushing's Disease | Drowsiness, Rash, Weakness, Nausea, Loss of Appetite, Hypotension, Hypothyroiism, Blood Dyscrasias, Induces Warfarin Metabolism |
| Lysodren | Mitotane | Cytotoxic Drug, Suppresses ACTH Secretion & Reduces Synthesis of Cortisol | Divided Doses | PO | Cushing's Disease | Monitor Cortisol, N/V/D, fatigue |
| Metopirone | Metyrapone | Decreased Cortisol Synthesis By Inhibition of 11-Hydroxylase Activity | 4 to 6 Divided Doses | PO | Cushing's Disease | N/V, Dizziness, Sedation |
| Decadron, Deameth, Dexone, Headrol | Dexamethasone | Inc Blood Glucose & Fat Deposition, Catabolic Effects, Inhibition of Inflammation & Immunosuppression, Vasoconstriction, Reduce PG & Leukotriene Synthesis, Dec Neutrophils & Inhibit Macrophage Fxn | 0.75mg, Long Half-Life, #1 Anti-Inflammatory Potency | PO | Adrenal Insufficiency | HTN, Na+ & Fluid Retention, Atherosclerosis, Insomnia, Anxiety, Depression, Psychosis, Obesity, Hyperglycemia, Hypokalemia, Amenorrhea, Impotence, Cataracts, Glaucoma, Infections, Impaired Wound Healing, Leukocytosis, Myopathy, Osteoporosis, Take w/Food 9 |
| Hylorel | Guanadrel | AdrenergicInhibitor (peripheral a2-agonist, inhibiting release of neurotransmitter) | BID | PO | Refractory HTN | Postural Hypotension, Diarrhea |