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Pharm Terms ch5

Pharmacodynamics how a medicine changes the body
Frequency distribution curve graphical representation of the number of patients responding to a drug action at different doses
Graded dose-response curve observing and measuring the patient's response obtained at different doses of the drug
Potency produces a therapeutic effect at a lower dose
Efficacy magnitude of maximal response that can be produced from a particular drug
Receptor cellular macromolecule to which a medication binds in order to initiate its effects
Second messenger triggered once drugs are bound together that will then stimulate or inhibit normal activity within the cell
Nonspecific cellular responses drug act independently of cellular receptors and are associated with other mechanisms such as changing the permeability of cellular membranse
Agonist produces same type of response as the endogenous substance
Partial agonist medication that produces a weaker response than an agonist
Antagonist prevents the endogenous chemical from acting
Idiosyncratic responses unpredictable and unexplained drug reactions
Pharmacogenetics area of pharm that examines the role of heredity in drug response
Pharmacogenomics deals with the influence of genetic variation on drug response in patients



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