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Pharm Terms ch5
| Term | Definition |
|---|---|
| Pharmacodynamics | how a medicine changes the body |
| Frequency distribution curve | graphical representation of the number of patients responding to a drug action at different doses |
| Graded dose-response | curve observing and measuring the patient's response obtained at different doses of the drug |
| Potency | produces a therapeutic effect at a lower dose |
| Efficacy | magnitude of maximal response that can be produced from a particular drug |
| Receptor | cellular macromolecule to which a medication binds in order to initiate its effects |
| Second messenger | triggered once drugs are bound together that will then stimulate or inhibit normal activity within the cell |
| Nonspecific cellular responses | drug act independently of cellular receptors and are associated with other mechanisms such as changing the permeability of cellular membranse |
| Agonist | produces same type of response as the endogenous substance |
| Partial agonist | medication that produces a weaker response than an agonist |
| Antagonist | prevents the endogenous chemical from acting |
| Idiosyncratic responses | unpredictable and unexplained drug reactions |
| Pharmacogenetics | area of pharm that examines the role of heredity in drug response |
| Pharmacogenomics | deals with the influence of genetic variation on drug response in patients |