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Pharm Terms ch4
Term | Definition |
---|---|
Pharmacokinetics | study of drug movement throughout the body |
Absorption | movement of a substance from its site of administration across body membranes |
Dissolution | rate that determines how quickly the drug disintegrates and disperses into simpler forms |
Distribution | transport of drugs throughout the body |
Affinity | attraction, for certain meds; bone marrow, teeth, eyes, and fat tissue have a high attraction. |
Drug-protein complexes | too large to cross capillary membranes and not available for distribution to body tissues |
Blood-brain barrier | prevents chemicals and meds from entering brain |
Fecal-placental barrier | prevents chemicals and meds from entering the placenta |
Metabolism | also called biotransformation, process of chemically converting a drug to a form that is more easily removed from the body |
Conjugates | side chains during metabolism, makes drugs more water soluble and more easily excreted by the kidneys |
Hepatic microsomal enzyme system | metabolism in the liver is accomplished by this |
Enzyme induction | ability to increase metabolic activity in the liver |
Pharmacogenomics | the study of genetic variations that influence an individual's response to drug therapy |
First-pass effect | important mechanism since a large # of drugs are rendered inactive by hepatic metabolic reactions (sublingual, rectal, parenteral bypass it) |
Prodrugs | have no pharmacologic activity unless they are first metabolized to their active form by the body |
Excretion | drugs removed from body by this process |
Enterohepatic recirculation | bile circulated back to the liver by this |
Minimum effective concentration | amt of drug required to produce a therapeutic effect |
Toxic concentration | level of drug that will result in serious adverse effects |
Therapeutic range | plasma drug concentration between the minimum effective concentration and the toxic concentration |
Onset of drug action | the amt of time it takes to produce a therapeutic effect after drug administration |
Peak plasma level | occurs when the medication has reached its highest concentration in the bloodstream |
Duration of drug action | amt of time a drug maintains its therapeutic effect |
Plasma half-life | length of time required for the plasma concentration of a medication to decrease by one-half |
Loading dose | higher amt of drug, often given only once or twice to "prime" the bloodstream with a sufficient level of drug |
Maintenance doses | given to keep the plasma drug concentration in the therapeutic range |