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Pharm test 1

botulinum toxin blocks release of ach from nerve terminal
alpha-latrotoxin causes mass release of ach from nerve terminal
pilocarpine muscarinic agonist- dry mouth
bethanechol muscarinic agonist- post op urine retention
cevimeline muscarinic agonist - sjogren's
atropine muscarinic antagonist - crosses bbb - antidote for physostigmine and war gases
scopolamine muscarinic antagonist - crosses bbb - antiemetic
physostigmine ACh E inhibitor - will cross bbb
edrophonium ACh E inhibitor - very short acting - diagnose m. g.
neostigmine ACh E inhibitor - intermediate acting - reversal for non-depolarizing nmj blocker - treatment for m. g.
Malathion, parathion, diazinon Irreversible ACh E inhibitor - insect repellant
Sarin, soman, tabun Irreversible ACh E inhibitor - war gases
2 - pralidoxime ACh E reactivator - must be used within 12 hours - attractive to the irreversible ACh E inhibitors more than the ACh E enzyme
Diazepam Used to prevent convulsant effects from too much ACh in the brain
respiratory support needed for too much or too little ACh or nmj blockers or succ
nicotine Ganglionic stimulator - full agonist
veranicline Ganglionic stimulator - partial N agonist
tubocurarine Long duration non-depolarizing nmj blocker
pancuronium Intermediate duration non-depolarizing nmj blocker
mivacurium Short duration non-depolarizing nmj blocker
Succinylcholine Non-competive depolarizing nmj blocker
Norepinephrine A1, A2, B1 - will cause increased vasoconstriction more than epinephrine
Epinephrine A1, A2, B1, B2 - will cause more dilation and higher HR at lower doses but a bolus will get constriction and decreased HR from reflex
Dopamine DA, A1, B1 - will increase urine output at low doses and is good for CHF
Phenylephrine A1 agonist
Ephedrine A1 agonist, also an indirect adrenergic agonist because it increases NE at synaptic cleft similar to amphetamine and tyramine
Pseudoephedrine A1 agonist, also and indirect adrenergic agonist
Clonidine A2 central agonist
Methoxamine A1 agonist
Oxymetazoline A1 and peripheral A2 agonist
Naphazoline A1 agonist
Isoproteronol B1 and B2 agonist - bradycardia and cardiac arrest
Dobutamine B1 agonist - CHF
Albuterol B2 agonist - asthma/COPD
Terbutaline B2 agonist - asthma/COPD
Metaproteronol B2 agonist - asthma/COPD
Ritodrine B2 agonist - relaxes uterus
Phenoxybenzamine A1 and A2 antagonist - non-competative action - used for pheochromocytoma
Phentolamine A1 and A2 antagonist - competative action - used for alpha agonist OD and restore sensation after dental anesthesia
Prazosin A1 antagonist - for hypertension and BPH
Propranolol B1 and B2 antagonist
Nadolol B1 and B2 antagonist
Timolol B1 and B2 antagonist
Pindolol B1 and B2 antagonist
Atenolol B1 antagonist
Metoprolol B1 antagonist
Labetalol B1, B2, A1 antagonist
Carvedilol B1, B2, A1 antagonist
B1 and B2 non-selective antagonists used to treat... htn, angina, MI, arrythmia, stage fright, glaucoma, tremor, migraine, anxiety
B1 selective antagonists used to treat... Cardioselective so decrease HR but dont affect people with asthma unless the dose is too high then it will have b2 effects
B1, B2, A1 non-selective antagonists used to treat.. CHF, they block biased agonists and teach the heart to beat differently
Tyramine Indirect adrenergic agonist - rides on reuptake 1 (NET) and gets in terminal and kicks out NE
Tyramine is in what foods... wine, cheese, beer, fish
Amphetamine Indirect adrenergic agonist - rides reuptake 1 and releases NE, high A1 and A2 so BP up and reflex HR down. High NE fights against reflex brady and can cause arrythmias
Cocaine NE uptake inhibitor - by blocking NET back into the cell; Also Na channel blocker and can cause numbness
Trycyclic antidepressant NE uptake inhibitor
Guanethadine Neuronal blocker - inhibits NE release similar to botox with ACh, problem is if bp goes down the reflex would say to increase sympathetic and release NE but this drug prevents that HR and BP stay down
Reserpine Neuronal blocker - inhibits vesicular uptake of NE so it gets eaten up by intraneuronal monoamine oxidase
Created by: kdurel