Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Ch.1 Pharm
Pharmacokinetics, Pharmaceutics, Pharmacodynamics
| Question | Answer |
|---|---|
| which form of drugs do not go through the pharmaceutic phase? | Sub Q, IM, and IV |
| what is the pharmaceutic phase? | becoming a solution, crosses the membrane |
| which form of meds undergo the dissolution process? | PO only |
| what is the dissolution process? | turning drug into solution before absorption |
| the doctor informs you there are excipients in the drugs.. what is that? | fillers to enhance the dissolution |
| Tablets must go through this process to break off into smaller bits.. what is it? | disintegration |
| where is the certain environment better for disintegration? | an acidic environment |
| older woman have less gastric acidity in their stomachs. what is important to remember about their bodies ability to absorb drugs? | it will absorb slower compared to a younger person |
| compared to a regular pill, how will enteric coated pills react? | they resist disintegration... it will be a delayed process |
| which pills can you not crush? | enteric coated |
| what is the pharmacokinetic phase? | drugs moving to different body compartments |
| when is this an important process | when watching out for adverse effects of the drugs |
| what are the processes of pharmacokinetics? | absorption, distribution, metabolism, elimination |
| what is absorption | moving drug particles from GI tract to body fluids |
| where are oral drugs absorbed | SI |
| digestive enzymes destroy___ | protein based drugs |
| what is passive absorption vs active absorption | passive occurs by diffusion, easier to pass through with no energy active requires a carrier and extra energy |
| what is pinocytosis | engulfing.. carrying |
| which kind of solubility will just pass through? | lipid soluble |
| which kind of solubility needs a carrier? | water soluble |
| if something has no charge and is nonionized does it need a carrier? | no - it will just pass through |
| which foods should you not eat with enteric coated pills | those high in fat |
| what is the first pass effect | passes straight to the liver first |
| what does this do to the concentration of the drug | makes it less potent |
| what is the vocab word for the % of a drug that reaches the systemic circulation? | bioavailability |
| if you were to put an IV in vs taking oral pills, which would get to the systemic circulation faster? | IV |
| which has 100% bioavailability | IV |
| which will affect the absorption of a drug A. form of drug B. GI motility C. food present in stomach D. route of drug E. toxins around the air F. blood flow | everything except E |
| what can occur if there is too much drugs actively in your system | toxicity |
| a grandma has a slower absorption rate.. what should you do differently with the drugs you give her? | (-) the drug serum concentration |
| what is distribution | becoming available to the body |
| what is distribution affected by? | BF, affinity, protein- binding affect |
| is unbound drugs in your body good or bad | bad- they are active in your body and will last there longer |
| 2 drugs have a high competition for binding sites.. what do you keep track of with this patient receiving these drugs | watch for their serum protein level because they can compete for a binding spot and it could become toxic |
| who should you pay most attention to in this category? | older people |
| what is metabolism also called | biotransformation |
| where is the primary site for this process | the liver |
| what is t 1/2 | half life- the time it takes for half of the drug to be eliminated from the body |
| short t1/2 | 4-8 hrs |
| long t1/2 | 24 + hours |
| how are drugs eliminated from the body? | kidneys |
| other ways? | bile, feces, urine, saliva, sweat, breast milk |
| if you are taking aspirin it is good to take which kind of drink with it in order to promote an acidic environment | cranberry juice |
| what is the creatinine clearance test | compares level of creatinine in blood vs. urine |
| which groups of people is this automatically lowered in | older people and woman |
| when your creatinine clearance is low what should you do to make sure you don't create toxicity | (-) drugs |
| what is the pharmacodynamic phase? | study of how drugs affect the body |
| give an example of a primary symptom vs a secondary symptom when taking Benadryl | primary- alleviates allergies secondary- constipation |
| the doctor says one patient has a tolerance of 3 mg for Advil while another pt has a tolerance of 6 mg. what is that range called? | dose response |
| what is it called for the time it takes the symptoms to dissapear? | onset of action |
| what is it called for how long the effect works on the pt? | duration of action |
| what does the receptor theory describe? | if there is a better fit there will be a stronger connection |
| a drug blocks a certain problem in your body.. what is this an example of | antagonist |
| this drug helps produce an effect on your body... what is this an example of? | agonist |
| this drug affects multiple site on your body. which kind of drug is this | nonspecific |
| this kind of drug affects various receptors on your body. which kind of drug is this | nonselective |
| name the actions drugs have on your body | stimulate, replace, inhibit, irritate |
| suzie can have 3 mg of advil and 6 mg will kill her.. whats this called | therapeutic index |
| the closer that it gets to __.. the greater the chance it will kill you | 1 |
| if your therapeutic range is __ you must monitor the pt carefully | narrow |
| when do you measure the peak | at the highest amount of rate of absorption |
| when do you measure the trough | before the next dose.. rate of elimination |
| what is the peak drug level | highest amount of PLASMA CONCENTRATION at a specific time |
| what is a loading dose | large initial dose to get fast results |
| which is the side effect vs adv. effect: Benadryl makes you sleepy but if you are allergic you could go into tachyphylaxis | sleepy= side effect tachy= adv. |
| an african american responds to ACE inhibitors differently than a caucasian does.. what is this an example of | pharmacogenetics |
| tolerance vs. tachyphylaxis | tolerance is (-) response over course tachy- rapid decline |
| placebo effect | psychological effect that meds are helping when they are actually chemically altered |
| which specific symptoms should you asses a pt for | tachycardia, dry mouth, blurred vision, constipation, urinary retention |
Created by:
10210590749069944
Popular Pharmacology sets