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VT Week 7

Diabetes Drugs

QuestionAnswer
Metformin MOA Decrease hepatic gluconeogenesis, Increase insulin sensitivity.
Metformin Indication Type II DM (ovarian cysts off label)
Metformin PK Unchanged in urine
Metformin Side Effects GI upset, weight loss, mettallic taste, lactic acidosis.
Metformin Contraindications Liver disease, Kidney disease, dehydration, surgery
Suflonylureas (indication) Type II DM
Suflonylureas (MOA) Blocks K+ in B-cell membrane and depolarization - increases pancreatic insulin secretion via Calcium influx.
Suflonylureas Side Effects Hypoglycemia, weight gain,
Sulfonylureas (contraindications) Prenancy, kidney disease.
Created by: kinney84
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