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IOS6 exam3

Pharmacology of Cancer Drugs

QuestionAnswer
Mechanism of resistance of alkylating agents Decreased permeation of actively transported drugs, increased activity of DNA repair enzymes, increased glutathione, increased rate of metabolism (cyclophosphamide)
Method used to deplete glutathione and thus overcome one mechanism of resistance to alkylating agents... buthionine sulfoximine (BSO)
Toxicities of alkylating agents leukemogenic, bone marrow suppression, toxic to intestinal mucosa (lesser exent), pulmonary fibrosis, endothelial damage (at high doses)
MOA of platinum compounds Exact mechanism unknow, but they form DNA adducts
Major mechanism of resistance to platinum compounds DNA repair enzymes
Cisplatin uses and toxicities Broad activity useful in epithelial malignanciesrenal proximal tubular necrosis, ototoxicity
Carboplatin uses and toxicities Used for ovarian cancerrenal proximal tubular necrosis, ototoxicity (less than cisplatin)
Oxaliplatin uses Ovarian and cervical cancer (more effective than other 2 platinum compounds because DNA repair enzyme proficient cells are equally effective).
MOA of antimetabolites Interfere with DNA synthesis (S phase)
MOA of methotrexate (antimetabolite) Dihydrofolate reductase inhibitor thus blocking the regeneration of tetrahydrofolate, and also inhibits folate dependent enzyme of purine and thymidine synthesis
MOA of pemetrexed (antimetabolite) Inhibits thymidylate and purine biosynthesis in addition to dihydrofolate reductase.
Created by: ranjc25
Popular Pharmacology sets

 

 



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