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Hepatitis drugs

hepatitis drugs

QuestionAnswer
Lamivuridine (NucleoSide analog) MOA inhibits HBV DNA polymerase via chain termination/ some anti-HIV activity
Lamivuridine PK Renally eliminated/ no drug interactions
Lamivuridine dosing oral/ once daily
Lamivuridine AE none
Adefovir (NucleoTide analog) MOA inhibits HBV DNA polymerase via chain termination/ some anti-HIV activity
Adefovir PK prodrug/ renally eliminated/no drug interactions
Adefovir AE gradual delayed renal toxicity (avoid w/ other renal toxic agents) increases SrCr and PO4!!
Entecavir (NucleoSide analog) MOA inhibits HBV DNA polymerase via chain termination AND may inhibit other ways also!!!****
Entecavir PK W/O Food/ renally eliminated
Entecavir dosing oral/ once daily
Entecavir AE nothing
Telbivudine (NucleoSide analog) MOA inhibits HBV DNA polymerase via chain termination
Telbivudine PK renally elimanted
Telbivudine dosing oral/ once daily
Telbivudine AE little maybe myopathy (small %) or increasesed CK
Tenofovir (NucleoTide analog) MOA inhibits HBV DNA polymerase via chain termination
Tenofovir PK renally eliminated
Tenofovir dosing oral/ once daily
Tenofovir AE not much maybe osteoporosis/ renal toxicity
Tenofovir against HIV fully active against HIV at normal dose
NucleoTide analogs against HBV adefovir, tenofovir
NucleoSide analogs against HBV lamivudine, Entecavir, Telbivudine
Interferon MOA inhibit viral replication and enhances MHC
Pegylated alpha interferons (PEG) PK hepatically cleared (steady state at 5-8 weeks
PEG Dosing subQ weekly, some viruses may have different genotype and alter treatment
PEG AE high %/ flu-like symptoms/ psychiatric/ many more
PEG drug interactions decreases clearance of theophylinne and methadone and increases suppression of other myelosuppresive agents
PEG used in what HBV/ HCV
Ribavirun MOA inhibits RNA in virus
Ribavirun PK renally
Ribavirun dosing 2x a day w/ food / caution in renal insufficient
Ribuvirun AE anemia, teratogenic and carcinogenic, skin rash, GI symptoms
Ribuvirun drug interactions with other myelosuppresive agents (IFN)
Ribuvirun directions must be given with IFN
Created by: sambone
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