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Intro of Pharm Tech

Ch. 11 - Factors affecting drug activity

neonate up to 1 month after birth
infant 1 mon to 2 years
child 2 - 12 years
adolescent 13 - 19 years
adult 20 - 70 years
elder older than 70 years
pharmacogenomics a field of study that defines the hereditary basis of individual differences in absorption, distribution, metabolism, and excretion (the ADME processes)
acute viral hepatitis an inflammatory condition of the liver caused by viruses
cirrhosis a chronic liver disease causing loss of function
hyperthyroidism a condition in which thyroid hormone secretions are above normal, often referred to as an overactive thyroid.
hypothyroidism a condition in which thyroid hormone secretions are below normal, often referred to as an underactive thyroid.
obstructive jaundice an obstruction of the bile duct that caused hepatic waste products and bile to accumulate in the liver
adverse drug reaction an unintended side effect of a medcation that is negative or in some way injurious to a patient's health.
anaphylactic shock a potentially fatal hypersensitivity reaction producing severe respiratory distress and cardiovascular collapse.
carcinogenicity the ability of a substance to cause cancer.
hypersensitivity an abnormal sensitivity generally resuting in an alleric reaction.
idiosyncrasy an unexpected reaction the first time a drug is taken, generally due to genetic causes.
complexation when two different molecules associate or attach to each other.
displacement a drug that is bound to a plama proten is removed when another drug of greater binding potential binds to the same protein
enzyme induction the increase in hepatic enzyme activity that results in greater metabolism of drugs.
enzyme inhibition the decrease in hepatic enzyme activity that results in reduced metabolism of drugs.
additive effects the summation in effect when two drugs w/ similar pharmacological actions are taken.
antidote a drug that antagonizes the toxic effect of another
potentiation when one drug w/ no inherent activity of its own increases the activity of another drug that produces an effect.
synergism when 2 drugs w/ similar pharmacological actions produce greater effects than the sum o individual effects.actions
drug-drug interactions do not alter the drugs' disposition but interact at the site of action.
drug-diet interactions when elements of ingested nutrients interact w/ a drug and this affects the disposition of the drug.
Created by: Hip