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IBD drugs

QuestionAnswer
Sulfasalazine indicated for what type of UC? maintenance? mild-moderate UC.... maintenance of remission of UC
Mesalamine indicated for what type of UC? maintenance? mild-moderarte UC..... maintenance of remission of UC
Olsalazine indicated for what type of UC? maintenance? ONLY MAINTENANCE (rarely used)
Balsalazide indicated for what type of UC? maintenance? mild-moderate... no
Glucocorticosteroids MOA cross membrane and modify transcription, inhibits inflammation
Glucocorticosteroids SIde effects increased glucose, BP, and lipid profile...GI distress...lots more
Glucocorticosteroids indications severe UC and CD uncontrolled by other medications
Monitor what in 5-ASA's LFT's and SCr/BUN
Immune modulators.... (used for CD and UC) Infliximab, mercaptopurine, azathioprine, cyclosporine, methotrexate
Infliximab MOA monoclonal antibody against TNF-alpha
Infliximab indications... moderate to severe treatment resistant CD, may even close fistulas!!, also maintenance of remission
Infliximab Side effects increase infections, liver impairment
Mercaptopurine MOA purine derivative, cell cycle specific (S- phase)
mercaptopurine indications off label treatment refractory CD and UC
Azathioprine... same as mercaptopurine
Cyclosporine MOA inhibits first phase of T-cell activation
Cyclosporine Side effects high lipids, high TG, hyperkalemia, hyperglycemia, increased SCr and BUN
Cyclosporine indications off-label treatment-refractory CD or steroid dependent UC
Warning signs of IBS (ROME CRITERIA) rectal bleeding, weight loss, iron-deficient anemia, nocturnal symptoms, family history
IBS drug for abdominal pain antimuscarinics (competitive inhibitor at cholinergic receptors, results in decreased mobility)
IBS drugs for diarrhea anti-diarrheals and serotonin antagonists
Loperamide (anti-diarrheal) MOA interferes with peristalsis by direct action on circular and longitudinal muscles of intestinal wall
Diphenoxylate (anti-diarrheal) MOA focus on smooth muscles, chemically related to opioids and has their effect at high doses
Alosetron (serotonin antagonist) MOA selectively blocks GI based seratonin receptors
Alosetron indication/warning women with severe IBS-D that hasn't been taken care of with other drugs.... BLACK BOX WARNING: ischemic colitis and death!!
IBS constipation drugs laxatives, selective chloride channel activators
Lubiprostone (selective chloride channel activator) MOA pushes Cl into lumen through C-2 channels
Lubiprostone indications
Created by: sambone
Popular Pharmacology sets

 

 



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