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Atropine effects
Effects of atropine on different physiologic processes
| Process | Normal PNS effect... | Normal SNS effect... | Effect of Atropine |
|---|---|---|---|
| Blood pressure | no effect (vascular sm. m. only innervated by SNS) | increase BP d/t vasoconstriction | no effect |
| Pupillary size | miosis (constriction) | mydriasis (dilation) | mydriasis (PNS blocked, SNS unmasked) |
| Accommodation for near vision | stimulation (accommodates) | n/a | cycloplegia - lens can't accommodate well (PNS block) |
| Resistance to airflow in bronchial tree | increased resistance (bronchoconstriction) | relaxation, decreased resistance | decrease resistance (block PNS) |
| GI motility | stimulates | inhibits | decreases (block PNS) |
| Bladder function | stimulates detrusor muscle, relaxes sphincter (stimulates bladder function) | decrease detrusor tone, increase sphincter tone (inhibits bladder function) | decrease bladder function (block PNS) |
| CNS function | M1 receptors in brain | n/a | block normal PNS function --> confusion, delirium, amnesia, coma (higher than normal doses) |
| Secretions of exocrine glands (salivary, lacrimal, bronchial, sweat) | stimulation | stimulation (sweat glands, ACh release) | decrease all secretions (block both PNS + SNS) |
| Heart rate | inhibition (- chronotropy) | stimulation (+ chronotropy) | increase HR (PNS block, SNS unmasked) |