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Antiulcer
| Question | Answer |
|---|---|
| H2 receptors end in "..." | -idine |
| PPI's end in "..." | -prazole |
| Surface acting agent... | Sucralfate |
| PGE-1 analog... | Misoprostol |
| Bismuth compounds.. | Bismuth Subsalicylate |
| H2 blockers MOA | inhibit H2 receptor on parietal cell from ECL |
| H2 blockers ADR | GI, rare-gynocomastia, Galactorrhea |
| H2 blockers Drug interactions | A LOT!- Cimetidine has the most (CYP 450) followed by Ranitidine |
| H2 blocker contraindications | Renal disease, pregnancy |
| PPI MOA | diffuse into parietal cells and becomes activated and blocks H+/K+ATPase |
| PPI length of efficacy | 24 hours, inhibits 80%-90% of acid....takes longer to take affect |
| H2 inhibitor length of efficacy | .5-2 hours, inhibits 50%-70% of acid.... quick relief |
| PPI ADR | GI, CNS maybe, myalgias |
| PPI drug interactions | omeprazole the worst (CYP 450) |
| what 2 agents inhibit absorption b/c raise gastric PH? | H2 blockers and PPI |
| PPI contraindications | reduce dose in hepatic disease |
| Sucralfate MOA | cross-linking polymer that adheres to epithelial cells around ulcer |
| Sucralfate ADR and contraindication | constipation....... renal failure |
| Misoprostol MOA | PGE1 analog that protect mucosa... increases mucosal blood flow and bicarbonate |
| Misoprostol Main use | NSAID induced gastric ulcers or high risk for ulcers (if must stay on NSIAD otherwise switch off NSAID) |
| Misoprostol ADR and contraindication | GI.... pregnancy (induces contractions) |
| Bismuth Compounds MOA | increase production of bicarbonate and antibacterial (prevent microbial attachment to mucosa) |
| Bismuth compounds ADR and Drug interactions | constipation and dark stools.... lots of drug interactions |
| Bismuth compounds contraindications | kids/pregnant, diabetics (hypoglycemia), ANTIPLATELETS AND ANTICOAGULANTS, renal failure |
| 3 drug therapy for H. Pylori | PPI, Clarithromycin, and amoxicillin or metronidazole |
| 4 drug therapy for H. Pylori | PPI or H2 blocker, Metrodinazole or clarithromycin, Amoxicillin or tetracycline, bismuth subsalicylate |
| Metrodinazole ADR and contraindications | induces metabolism of anti-TB meds and anti seizure meds..... alcoholic beverages, liver disease, CNS disease |
| duration of H. Pylori treatment | 7-14 days (the longer the better) often followed by PPI or H2 blocker for 2-6 weeks for complete healing of ulcer |
| tetracylcine useful with what problems? | amoxicillin allergy and metrodinazole resistance |
| short term relief in PUD | antacids and bismuth compounds |
| most effective against PUD | PPI |
| what drugs to use in pregnancy? | moderate-Ranitidine... severe-Lansoprazole |
| Bismuth compounds ADR and Drug interactions | constipation and dark stools.... lots of drug interactions |
| Bismuth compounds contraindications | kids/pregnant, diabetics (hypoglycemia), ANTIPLATELETS AND ANTICOAGULANTS, renal failure |
| 3 drug therapy for H. Pylori | PPI, Clarithromycin, and amoxicillin or metronidazole |
| 4 drug therapy for H. Pylori | PPI or H2 blocker, Metrodinazole or clarithromycin, Amoxicillin or tetracycline, bismuth subsalicylate |
| Metrodinazole ADR and contraindications | induces metabolism of anti-TB meds and anti seizure meds..... alcoholic beverages, liver disease, CNS disease |
| duration of H. Pylori treatment | 7-14 days (the longer the better) often followed by PPI or H2 blocker for 2-6 weeks for complete healing of ulcer |
| tetracylcine useful with what problems? | amoxicillin allergy and metrodinazole resistance |
| short term relief in PUD | antacids and bismuth compounds |
| most effective against PUD | PPI |
| what drugs to use in pregnancy? | moderate-Ranitidine... severe-Lansoprazole |
Created by:
sambone
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