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Antiulcer

QuestionAnswer
H2 receptors end in "..." -idine
PPI's end in "..." -prazole
Surface acting agent... Sucralfate
PGE-1 analog... Misoprostol
Bismuth compounds.. Bismuth Subsalicylate
H2 blockers MOA inhibit H2 receptor on parietal cell from ECL
H2 blockers ADR GI, rare-gynocomastia, Galactorrhea
H2 blockers Drug interactions A LOT!- Cimetidine has the most (CYP 450) followed by Ranitidine
H2 blocker contraindications Renal disease, pregnancy
PPI MOA diffuse into parietal cells and becomes activated and blocks H+/K+ATPase
PPI length of efficacy 24 hours, inhibits 80%-90% of acid....takes longer to take affect
H2 inhibitor length of efficacy .5-2 hours, inhibits 50%-70% of acid.... quick relief
PPI ADR GI, CNS maybe, myalgias
PPI drug interactions omeprazole the worst (CYP 450)
what 2 agents inhibit absorption b/c raise gastric PH? H2 blockers and PPI
PPI contraindications reduce dose in hepatic disease
Sucralfate MOA cross-linking polymer that adheres to epithelial cells around ulcer
Sucralfate ADR and contraindication constipation....... renal failure
Misoprostol MOA PGE1 analog that protect mucosa... increases mucosal blood flow and bicarbonate
Misoprostol Main use NSAID induced gastric ulcers or high risk for ulcers (if must stay on NSIAD otherwise switch off NSAID)
Misoprostol ADR and contraindication GI.... pregnancy (induces contractions)
Bismuth Compounds MOA increase production of bicarbonate and antibacterial (prevent microbial attachment to mucosa)
Bismuth compounds ADR and Drug interactions constipation and dark stools.... lots of drug interactions
Bismuth compounds contraindications kids/pregnant, diabetics (hypoglycemia), ANTIPLATELETS AND ANTICOAGULANTS, renal failure
3 drug therapy for H. Pylori PPI, Clarithromycin, and amoxicillin or metronidazole
4 drug therapy for H. Pylori PPI or H2 blocker, Metrodinazole or clarithromycin, Amoxicillin or tetracycline, bismuth subsalicylate
Metrodinazole ADR and contraindications induces metabolism of anti-TB meds and anti seizure meds..... alcoholic beverages, liver disease, CNS disease
duration of H. Pylori treatment 7-14 days (the longer the better) often followed by PPI or H2 blocker for 2-6 weeks for complete healing of ulcer
tetracylcine useful with what problems? amoxicillin allergy and metrodinazole resistance
short term relief in PUD antacids and bismuth compounds
most effective against PUD PPI
what drugs to use in pregnancy? moderate-Ranitidine... severe-Lansoprazole
Bismuth compounds ADR and Drug interactions constipation and dark stools.... lots of drug interactions
Bismuth compounds contraindications kids/pregnant, diabetics (hypoglycemia), ANTIPLATELETS AND ANTICOAGULANTS, renal failure
3 drug therapy for H. Pylori PPI, Clarithromycin, and amoxicillin or metronidazole
4 drug therapy for H. Pylori PPI or H2 blocker, Metrodinazole or clarithromycin, Amoxicillin or tetracycline, bismuth subsalicylate
Metrodinazole ADR and contraindications induces metabolism of anti-TB meds and anti seizure meds..... alcoholic beverages, liver disease, CNS disease
duration of H. Pylori treatment 7-14 days (the longer the better) often followed by PPI or H2 blocker for 2-6 weeks for complete healing of ulcer
tetracylcine useful with what problems? amoxicillin allergy and metrodinazole resistance
short term relief in PUD antacids and bismuth compounds
most effective against PUD PPI
what drugs to use in pregnancy? moderate-Ranitidine... severe-Lansoprazole
Created by: sambone
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