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Pharmacology
NSAIDS
| Question | Answer |
|---|---|
| Why is Acetaminophen not considered an NSAID? | Lack ant-inflammatory & antcoagulant properties |
| NSAID's with a high risk for hypertension? | Feldene, Indocin, Motrin |
| NSAID's with highest risk for GI problems? | Feldene, Indocin, Meclomen, Nalfon, Ansaid |
| Best representative of an NSAID... | Aspirin |
| NSAID's inhibit biosynthesis of what? | Prostaglandins |
| Increase sensitivity of pain receptors to mechanical pressure and the effects of other pain-producing substances? | Prostaglandins |
| "Normal" constituent in certain cells ex: stomach mucosa, kidneys..? | COX-1 |
| "Emergency" enzyme that synthesizes prostaglandins in response to cell injury? | COX-2 |
| What accounts for the primary side effects of NSAID's? | Inhibit the COX-1 enzyme which decreases the production of beneficial and protective prostaglandins |
| Factors that increase risk of serious GI damage...? | advanced age, hx of ulcers, use of multiple NSAIDs, use of high dose NSAID, use of other agents |
| What type of drug is more likely to inhibit production of the pathological prostaglandins, while sparing the production of beneficial ones? | COX-2 |
| What type of drugs can cause renal and hepatic problems by inhibiting the synthesis of prostaglandins that maintain blood flow and function? | Aspirin-like |
| COX-2 drugs have increased risk of...? | Clots in the coronary and carotid arteries |
| Often the first drug used to control pain in early stages of osteoarthritis and other musculoskeletal conditions? | Acetaminophen |
| What drug preferentially inhibits CNS prostaglandin production? | Acetaminophen |
| Pre-existing liver disease and chronic alcohol abusers are susceptible to liver damage cause by high doses of what? | Acetaminophen |
Created by:
txst spr 2009
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