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Anticoagulants
Anticoagulants quiz prep 12-17-15
| Question | Answer |
|---|---|
| How do antiplatelet agents (ADP Inhibitors) Plavix and Effien work? | Bind to ADP receptors on platelets |
| What are examples of ADP inhibitors? | Plavix and Effien |
| How do antiplatelet agents (Thromboxane A2 Inhibitor) work? | Aspirin prevents cyclo-oxygenase from producing the prostaglandin TXA2 |
| Example of a TXA2 Inhibitor: | aspirin |
| What is the name of a GP IIb/IIIa inhibitor: | Integrilin |
| How does integrilin work as an antiplatelet? | Blocks fibrin from binding to GP IIb/IIIa receptors |
| How do thrombolytic/fibrinolytic drugs work and what are they called? | Tissue plasminogen activators convert plasminogen to plasmin which breaks up fibrin strands holding clot together |
| How do thrombin inhibitors work? | prevent thrombin from converting fibrinogen into fibrin |
| List some examples of thrombin inhibitors | Angiomac/Bivalrudin; Pradaxa/Dabigatran; Fondaparinux/Arixstra |
| What drug prevents vitamin K from producing prothrombin in the liver? | Coumadin/warfarin |
| What drugs prevent prothrombinase from converting prothrombin to thrombin? | Heparin; Enoxaparin/Lovenox |
| What drugs produce increased fibrin degradation products in the blood? | Fibrinolytics (Streptokinase, urokinase and TPA derivatives like Tenecteplase) |
| What drugs does the reversal agent Vitamin K work on? | Coumadin/warfarin |
| What drugs does the reversal agent Protamine work on? | Heparin |
| What drugs does the reversal agent Amicar work on? | Thrombolytics (streptokinase, urokinase, tissue plasminogen activators) |
| What plasma protein binds to GP IIb/IIIa receptors on platelets? | Fibrin |
| What drugs stimulates the body's production of plasmin? | Tissuse plasminogen activators (TNK, Alteplase, Reteplase, SK, urokinase) |
| What drug is given for left atrial mural thrombus, deep vein thrombosis and preventing thrombus on mechanical prosthetic cardiac valves? | Coumadin/warfarin |
| What drugs does the INR lab test monitor? | Coumadin/warfarin |
| What drugs does the lab test ACT monitor? | Heparin |
| What drugs does the lab test FDP monitor? | Tissue Plasminogen Activators (TNK, Alteplase, Reteplase, SK, Urokinase) |
| What thienopyridines are ADP receptor inhibitors? | Clopidigrel/Plavix; Prasugrel/Effien |
| What drugs blocks the enxyme cyclo-oxygenasse in the platelet from producing Thromboxane A2? | Aspirin |
| WHat drug is alow molecular weight form of heparin? | Enoxaparin/Lovenox |
| What was the "clot buster" enzyme streptokinase derived from? | Streptococcus bacteria |
| What antibodies are used to produce the GP IIb/IIIa inhibitor ReoPro? | Murine (mice) |
| What drug is given to stop a CVA in progress? | Tenecteplase (TNK) |
| What thrombolytic enzyme is found naturally in the human kidney | Urokinase |
| What drug is used to prevent acute thrombosis of intracoronary stents? | Clopidogrel/Plavix |
| Platelet production of Thromboxane A2 is inhibited by: | Aspirin |
| List an example of an ADP antagonist | Plavix |
| Which ADP antagonist is given orally to patients who receive a Drug Eluting Stent? | Clopidigrel/Plavix |
| What is the antidote to Plavix? | There is no antidote |
| What is the antidote to Vitamin K/ Aqamephyton? | Coumadin |
| What is the antidote to Aminocaproic Acid/Amicar | TPA STK, UK |
| What is the antidote to Heparin? | Protamine |
| What Is Abciximab/Reopro? | GP IIb/IIIa Inhibitor (Ask pt if they have an allergy to mouse protein) |
| What stimulates te body's production of the protein plasmin? | Tenecteplase (TNK) 1 time IV push |
| The fibrinolytic drug given in a single IV bolus of 30 to 50 mg is: | Tenecteplase (TNK) |
| Clopidigral works on | ADP |
| Enoxaparin/ Lovenox: | prevents conversion of prothrombin to thrombin |
| Refludan/Hirudin is a | direct thrombin inhibitor |
| Following PTCA a cardiologist may wish to prevent thrombus formation by ordering | Eptafibatide/Integrillin (works on GpIIbIIIa) |
| What role does Calcium and CaMP play? | Help project outward the GPIIbIIIa receptors (causes it to change shape) |
| Bivalrudin/ Angiomax is a | Direct thrombin inhibitor |
| What is dereived from leech saliva> | Bivalrudin/Angiomax |
| Bivalrudin?Angiomax is what type of drug? | direct thrombin inhibitor |
| Integrilin/Eptifibatide blocks: | GPIIb/IIIa receptors on platelets |
| A patient on Coumadin experiences hamturia and hemoptysis. What might be administered to control these symptoms? | Vitamin K |
| Tenecteplase/ Tissue Palsminogen Activator (TPA) is what type of drug? | fibrinolytic |
| Aspirin works by | inhibiting thromboxane A2 release from platelets |
| The correct initial dose of aspirin in a patient with acute coronary syndrome is: | 162-325 mg chewed |
| LMWH is | more effective anticoagulant; more predictable dosing, lower risk of bleeding complications, less need of lab monitoring |
| What is the best long term anticoagulant for a patient with an artificial heart valve? | Coumadin |
Created by:
ICVT2b
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