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Anticoagulants

Anticoagulants quiz prep 12-17-15

QuestionAnswer
How do antiplatelet agents (ADP Inhibitors) Plavix and Effien work? Bind to ADP receptors on platelets
What are examples of ADP inhibitors? Plavix and Effien
How do antiplatelet agents (Thromboxane A2 Inhibitor) work? Aspirin prevents cyclo-oxygenase from producing the prostaglandin TXA2
Example of a TXA2 Inhibitor: aspirin
What is the name of a GP IIb/IIIa inhibitor: Integrilin
How does integrilin work as an antiplatelet? Blocks fibrin from binding to GP IIb/IIIa receptors
How do thrombolytic/fibrinolytic drugs work and what are they called? Tissue plasminogen activators convert plasminogen to plasmin which breaks up fibrin strands holding clot together
How do thrombin inhibitors work? prevent thrombin from converting fibrinogen into fibrin
List some examples of thrombin inhibitors Angiomac/Bivalrudin; Pradaxa/Dabigatran; Fondaparinux/Arixstra
What drug prevents vitamin K from producing prothrombin in the liver? Coumadin/warfarin
What drugs prevent prothrombinase from converting prothrombin to thrombin? Heparin; Enoxaparin/Lovenox
What drugs produce increased fibrin degradation products in the blood? Fibrinolytics (Streptokinase, urokinase and TPA derivatives like Tenecteplase)
What drugs does the reversal agent Vitamin K work on? Coumadin/warfarin
What drugs does the reversal agent Protamine work on? Heparin
What drugs does the reversal agent Amicar work on? Thrombolytics (streptokinase, urokinase, tissue plasminogen activators)
What plasma protein binds to GP IIb/IIIa receptors on platelets? Fibrin
What drugs stimulates the body's production of plasmin? Tissuse plasminogen activators (TNK, Alteplase, Reteplase, SK, urokinase)
What drug is given for left atrial mural thrombus, deep vein thrombosis and preventing thrombus on mechanical prosthetic cardiac valves? Coumadin/warfarin
What drugs does the INR lab test monitor? Coumadin/warfarin
What drugs does the lab test ACT monitor? Heparin
What drugs does the lab test FDP monitor? Tissue Plasminogen Activators (TNK, Alteplase, Reteplase, SK, Urokinase)
What thienopyridines are ADP receptor inhibitors? Clopidigrel/Plavix; Prasugrel/Effien
What drugs blocks the enxyme cyclo-oxygenasse in the platelet from producing Thromboxane A2? Aspirin
WHat drug is alow molecular weight form of heparin? Enoxaparin/Lovenox
What was the "clot buster" enzyme streptokinase derived from? Streptococcus bacteria
What antibodies are used to produce the GP IIb/IIIa inhibitor ReoPro? Murine (mice)
What drug is given to stop a CVA in progress? Tenecteplase (TNK)
What thrombolytic enzyme is found naturally in the human kidney Urokinase
What drug is used to prevent acute thrombosis of intracoronary stents? Clopidogrel/Plavix
Platelet production of Thromboxane A2 is inhibited by: Aspirin
List an example of an ADP antagonist Plavix
Which ADP antagonist is given orally to patients who receive a Drug Eluting Stent? Clopidigrel/Plavix
What is the antidote to Plavix? There is no antidote
What is the antidote to Vitamin K/ Aqamephyton? Coumadin
What is the antidote to Aminocaproic Acid/Amicar TPA STK, UK
What is the antidote to Heparin? Protamine
What Is Abciximab/Reopro? GP IIb/IIIa Inhibitor (Ask pt if they have an allergy to mouse protein)
What stimulates te body's production of the protein plasmin? Tenecteplase (TNK) 1 time IV push
The fibrinolytic drug given in a single IV bolus of 30 to 50 mg is: Tenecteplase (TNK)
Clopidigral works on ADP
Enoxaparin/ Lovenox: prevents conversion of prothrombin to thrombin
Refludan/Hirudin is a direct thrombin inhibitor
Following PTCA a cardiologist may wish to prevent thrombus formation by ordering Eptafibatide/Integrillin (works on GpIIbIIIa)
What role does Calcium and CaMP play? Help project outward the GPIIbIIIa receptors (causes it to change shape)
Bivalrudin/ Angiomax is a Direct thrombin inhibitor
What is dereived from leech saliva> Bivalrudin/Angiomax
Bivalrudin?Angiomax is what type of drug? direct thrombin inhibitor
Integrilin/Eptifibatide blocks: GPIIb/IIIa receptors on platelets
A patient on Coumadin experiences hamturia and hemoptysis. What might be administered to control these symptoms? Vitamin K
Tenecteplase/ Tissue Palsminogen Activator (TPA) is what type of drug? fibrinolytic
Aspirin works by inhibiting thromboxane A2 release from platelets
The correct initial dose of aspirin in a patient with acute coronary syndrome is: 162-325 mg chewed
LMWH is more effective anticoagulant; more predictable dosing, lower risk of bleeding complications, less need of lab monitoring
What is the best long term anticoagulant for a patient with an artificial heart valve? Coumadin
Created by: ICVT2b