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fungus
Stack #208071
Question | Answer |
---|---|
symptoms of vulvovaginal candidiasis | itching sore, irriating, burning w/ urination, cheese like discharge, gram stain similar to UTI |
vulvovaginal bug | candida albicans |
risk factors for vulvovaginal candidiasis | oral genital contact, initial sex (diaphram or spermicide use), abx use, douching, tight cloths |
vulvovaginal candidiasis pharm therapy...uncomplicated | uncomplicated (OTC): butoconazole (3 days), clotrimazole (1-7 days), miconazole (1-7 days), ticonazole (1 day).....uncomplicated RX: econazole (1tab), nystatin (14days), terconazole 1-7 days |
treat systmeically vulvovaginal candidiasis | Fluc (150), itra 200 twice |
are oral and topical therapies equivalent for azoles? | yes |
what makes a vulvovaginal candid complicated? | C glabrata, immunocompromised, DM, pregnant, recurrent more than 4 epi/year, severe symp |
how should itra be taken? | with acidic drink |
signs and symp of oropharyngeal candid | could have pain, white thick plaques around mouth, burning or pain, taste changes |
what is the bug for oropharyngeal candid? | C albicans....but 30-60% are colonized |
what are the 3 categories of risk factors for oropharyngeal condid? | disease related (DM, immunodiff (aids), hypothyroid, adrenal disfunction.....med related (immunosuppressants, radiation, dentures, broad spec abx)....gen conditions (premature, elderly, malnutrition, newborns |
how to treat oropharyngeal candid..ROUTE? | topical preferred, clotrimazole troche (4-5 times/day for 7-14 days)...nystatin susp, fluc tabl, itra susp |
how to treat esophageal? | fluc 14-21 days (preffered), itra 14-21 days, imporve in 2-3 days, resolve in 7-10 days |
name the 3 dermatophytic infections? | jock itch, ringworm, athletes foot |
treat of dermatophytic? | clotrimazole cream, econazole cream, ketoconazole cream, miconazole cream, nystatin cream, terbinafine cream, tolnaftate cream |
how to treat toenail and fingernail infxn | oral therapy..monitor LFT's....terbinafine (fingernails: 6 weeks, toenails 3-4 months), itraconazole: fingernailes 200mg /2months 1 week, toenails 3-4 months) |
invasive candidiasis risk factors (lots) | any cath/lines....GI procedure or mech ventilation....DM, Solid tumor, CV....immunosuppression, chemo, ICU, pancreatitis, TPN, corticosteroid administration |
what to do if fungal infection suspected systemically?? | TREAT IMMEDIATELY....fluc for albicans...know susceptibility |
what are the most common bugs for invasive candidiasis and other bugs? | albicans, krusei, glabrata |
what are the key patient and institutional charactoristics for antifungal therapy? (3) | common fungal species in your area, patient underlying conditions abx steroid use and length of ICU stay...other fungal risks |
what is onychomycosis? | fungal infection of the nails |
why is onychomycosis usually treated? | cosmetic reasons, sometimes pain |
how to treat onychomycosis?route? | ORAL only, terbinafine (fn: 6 weeks, tn: 3-4 months), itraconazole (fn: 2months 1 wk, tn: 3-4 monts) |
treat candiduria? | ampho B, fluc |
what drug to not use in candiduria | echinocandins |
when would you treat candiduria? | if cath is positive (pull then retest), if high risk for systemic disease (renal transplant, obstruction, immunocompromised) |
echinocandins (3) | micafubgin, capsofungin, anidulafungin |
echinocandins moa | |
do drug activity ones again |