Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Stack #206366
| Question | Answer |
|---|---|
| Methotrexate | DMARD: enzyme inhibition: anti cancer agent (hepatic, gi, blood (thrombocytopenia), not used with renal dysfunction) folic acid may decr adv effects |
| DMARD | For active infl disease. Goal to stop infl and jnt destruction |
| Thrombocytopenia | Due to immune dysfunction |
| Secondary Thrombocytosis | •Anemia due to iron deficiency •Cancer •Inflammation or infection •Surgery |
| Anti cytokines (TNF) | Enbrel; Anti cytokines bind with tnf and deactivate it; TNF directly involved with RA inflatmmation |
| DMARD drug names | Leflunomide (Arava) Infliximab (remicade) Anakinra(kineret) |
| Cyclosporine (Neoral) | DMARD; htn, nephrotoxicity; drug interxns (CA blockers, antibiotics, corticosteroids, antifungals) RA rx |
| Gold therapy | efx (blood disorders, renal dysfxn, dermatitis) tolerated better orally |
| Osteoporosis | Vit D facilitates Ca uptake; |
| Vit D analogue | Calcitrol, cod liver oil |
| Bisphonate | inhibit resorption w/o affecting formation |
| Alendronate (fosamax)risedronate (actonel) | BisphonateGI problems, myalgias, esophageal lesionsMust be taken hour before breakfast; remain standing or sitting hour after breakfast |
| Etidronate (Didronel) | Bisphonatefor Paget's disease and SCI heterotopic ossification |
| Calcitonin | reduces osteoclasitic activity; paget's disease; pain, myalgias, headaches |
| Teriparatide (Forteo) | has PTH and Raloxifene (Evista) a antiestrogen agent; osteoporosis in postmen women; hot flashes, leg cramps |
| Nitrates | Vasodilation; decr BP; decr work of heart; relief of coronary vasospasm; dizziness, headache, reflex tachycardia; Call EMS if no relief after 3 tablets |
| Angina | Nitrates, B Blockers, CA blockers, Anti Anxiety rx w/o cardiac effects (Zoloft, Paxil, and Ativan) |
| Diuretics | treat htn; hyperglycemia, hypokalemia |
| Thiazides | Hydrochlorothiazide; inhibit tubular reabsorption of NA and CL; not used with renal dysfunction |
| Loop Diuretics | furosemide (Lasix), Bumex, Edecrin; works on loop of henle; more effective than thiazides; safe use with elderly |
| Potassium Sparing Diuretics | Prevent hypokalemia; Aldactone, Dyrenium, Midamor; weak diuretics; may lead to hyperkalemia |
| Beta blockers | decr CO by slowing HR; avoid use with COPD, some types of angina, and DM; |
| Beta blockers | propanolol (inderal), nadolol, penobutolol (levatol) |
| B-Blocker side effects | depression, disorientation, cold extremities |
| C-Channel Blocker Names | Procardia, Cardizem, verapamil, norvasc |
| C-Channel Blocker function | decr Ca influx; decr heart contractilty, HR, and resistance to blood flow (causes vasodilation), dilated coronary arteries |
| C-Channel Blocker | Bradycardia, perip vasodilation caus flushin, headache, andkle swelling and reflex tachycardia |
| Reflex Tachycardia | Ca Channel Blockers, Nitrates |
| A-1 Blocker | prazosin (Minpress)block a-1 receptor sin sm muscle --> arterial and v. vasodilation;Syncope, headache, palpitations |
| A-2 Blockers | clonidine (catapres) methyldopa (aldomet) ; a-2 brain receptors (decr HR, BP); dry mouth, sedation, depression |
| A-2 adv rxns | clonidine (rebound htn on sudden w/drawal); Aldomet (mental acuity & hemolytic anemia) |
| warfarin | antagonist of Vit K; 3-6 days for effect; (hemorrhage,microemobli, not used with pregnancy) |
| Warfarin drug interactions | CHF, hepatic dysfxn, and malnutrition may decr VIT K-clotting factors and incr drug effect |
| Heparin | naturally occuring in body; Fragmin, Lovenox, and Innohep; less frequent dosing and not need to monitor prothrombin times |
| Aspirin | Antiplatelet; irreversibly inhibits platelets agrregating at injury; tx for CAD, angina, and MI |
| Clopidogrel (plavix) | antiplatelet: same as aspirin; used with PVD |
| Ticlopidine (Ticlid) | antiplatelet: same as aspirin: TIAs and stroke (GI symptoms, dizzines) ( |
| Diazepam | Valium; m relaxant; acts |
| Aspirin | Antiplatelet; anti-inflammatory, anti-pyretic, analgesic; (GI upset, nausea, gastritis) |
| NSAIDS-general | COX1&2 inhibitors ; Ibuprofen(advil, motrin) efx(edema, less GI irritation than aspirin) |
| COX-2 NSAIDS | Celecoxib (VIoxx, Celebrex, Bextra); were indicated for RA and DJD; inhibit COX-2 inflammation prostaglandins; antipyretic, anti inflammatory, and analgesic |
| Glucocorticosteroids | endogenouse (cortisol, hydrocortizone) synthetic (prednisone, dexamethasone) |
| Glucocorticosteroids | Inhibit capillary dilatin, edema, & migration of leukocytes and macrophages to affected area |
| Glucocorticosteroids ADV RXN | sudden w/drawal: fever, malaise, althralgia; depression, anxiety, euphoria, mood swings, nervous, cataracts, Cushingoid symptoms, edema, hyperglycemia, osteoporosis, myopathy, GI disturbances |
| Diazepam | Valium: m. relaxant; acts centrally; tx spasm |
| Tizanidne | Zanalfex: m. relaxant; acts at spinal cord; tx spascticity; efx(hypotension) |
| Chlorzoxaone (Parafon Forte) cyclobenzaprine (flexeril carisprodol (soma) methocarbamol (robaxin) orphenadrine (norflex) | act at brain stem/ spinal cord; temp relief of local, acute spasm; flexeril efx(tachycardia, blurry vision, dry mouth) |
| baclofen | lioresal: m. relaxant; act at brain and SC inhibitin NT substance P; reduce inflamm and pain ; tx spasticity and painful spasms; efx (drowsiness, incr seizures with epilepsy pt) |
| Dantolene | Dantrium: m. relaxant; act olcally on m fiber, blocks Ca; tx chronic spasticity; efx (dizziness, dryness, diarrhea) |
| opiod narcotics | morphine, codeine, hydrocodone (vicodin) methadone, oxycodone (percodet, percodan, oxycontin) meperidine (demerol)hydromorphone (dilaudid) |
| opiod narcotic effects | analgesia, antitussive, dyspnea (MI, acute pulm edema, LVF), antidiarrheal; efx (drowsinesss, nausea, vomiting) |
| Fentanyl | duragesid, actiq: opiod narcotic for stable, chronic pain |
| Non-opiod narcotic | acetaminophen (tylenol); mild pain relief; antipyretic; efx (sever liver damage and fatal effects in overdosed quantities |
| ACE inhibitors | Pril's; Quinipril (accupril) captopril (capoten) fosinopril (monopril) benazepril (lotensin):arteriolar vasodilation, decr perip resistance, incr blood flow |
| ACE inhibitor | efx (non productive dry cough, decr taste perception) (excessive hypotension, hyperkalemia, angioedema) |
| Digoxin | Lanoxin; tx systolic dysfunction and arrhythmias, used with CHF; incr force of contraction w/o incr oxygen demand; adv efx (GI problems and confusion) |
| Vasodilator | Hydralazine (apresoline) and minoxidil; efx (GI, headache, flushing, nasal congestion) adv efx (Lupus like, arthralgia, skin rash, reflex tachycardia--> angina attack) |
Created by:
andreythedon
Popular Pharmacology sets