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Anti Inflam Drugs

Salicylates Drugs Aspirin (Bayer, Ecotrin).....baby:81mg, regular: 325mg given PO/PR/SR Mechanism: -Inhibit COX 1 and 2 enzymes Results in: -Anti inflammitory, Prostaglandins inhibition -Decreased platelet aggregation
Salicylates Drugs Indicat: Chest Pains,Post cardiac event to reduce pain and inflammation, antipyretic Drug interaction: with (anticoagulant, anti platelets and NSAIDS) Adverse Reaction: -bleeding - allergy to aspirin(present with tennitis and broncospasms)
Salicylates Drugs Precaution: -surgical stop 7-10 days prior -don't crush meds (enteric coated) -no ETOH -NOT FOR KIDS (cause rey's syndrome), Cat D
NSAIDS DRUGS Ibuprofen (Motrin) and Advil PO Mechanism: Inhibits COX enzymes 1 & 2 Indication: antininflammatory, Antipyretics and Analgesics dosage: max 2400mg/day...highly protein bound Loss of stomach linning
NSAIDS DRUGS Drug interaction: -Oral anticoagulant -increase effects of phenotoin(compete for same site) -Not for pregnancy -cause Nephrotoxicity -anaphylaxis -causes fluid retention
NSAIDS Contraindictions -nsaids allergy -peptic ulcers -renal/hepatic failure -3rd trimester pregnancy -bleeding disorders -heart disease (exept ASA) -children -allergy to aspirin(present with tennitis and broncospasms)
NSAIDS N/I and P/T - dosage adjustment for renal/hepatic pts -mon. s/s of bleeding -take with food -no othe anticoagulant unless px -no ETOH -off for 7-10 days b/4 surgery -avoid in trimester -deceses effectiveness of antihypertensives - for long term consider PPI
Herbal alert (may increase risk of bleeding with NSAIDS -Garlic -Ginger -Ginko
Celecoxib (Celebrex)-PO selective COX 2 INHIBITOR Indication: -Rheumatoid and osteoarthritis dosage: 200mg daily or divided**** Caution: renal/hepatic dysfunction heart failure hx of GI Bleeding anticoagulant use cardiac disease
Celecoxib (Celebrex)-PO Patient education baby aspirin maybe px take with food no ETOH report gastric irritation cause fluid retention report s/s of heart attack S/E: gastric upset,diarrhea, heart burn, nausea ulcer, renal dysfunction give 2hrs before or after aluminum antacids
NSAIDS AND CELEBREX BLACK BOX WARNING Cardiovascular risk may incr risk of serious and fatal cardiovascular thombotic events: MI and Stroke GI Risk may incr risk of serious and fatal GI adverse events:bleeding, ulcer and stomach or intestine perforations, elderly at most risk.
What is gout its an inflammatory condition caused by increased uric acid.Gout, a painful form of arthritis, occurs when high levels of uric acid in the blood cause crystals to form and accumulate around a joint. -Its common in the big toe -purines increase acids
What is gout foods to avoid purines in: - Meat -fish -alcohol -increase in fructose syrup normal levels 2.6-7.2
ANTI GOUT DRUGS Allopurinols (Zyloprim) -gout tx/prophylaxis -inhibits uric acid synthesis -take with food and fluid -can increase effect of warfarin(slow met. down warfar) -S/E: N/V, stomatitis,metallic taste Monitor CBC. Gout is assoc. with agranulation (critical decrease in WBC count)
ANTIGOUT Nursing Intervention -Assess for renal/hepatic impairment (broken down through the liver) -dietary teaching -I/O's -assess serum uric acid levels -increase fluid intake - report S/E to HCP
Created by: amoniffa