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HIV/AIDS

HIV/AIDS Brand, Generic, Abbreviation, Class, Notes (6/14/05)

BrandgenericAbbreviationClassNotes
Ziagen abacavir ABC NRTI Only NRTI w/out renal dosing, Do NOT rechallenge pts w/ hypersensitivity rxn
Videx, Videx EC didanosine ddI NRTI Weight based dosing, don't combine w/ other "d" NRTI's (d4t, ddC) d/t additive periph neuropathy, pancreatitis, lactic acidosis
Emtriva emtricitabine FTC NRTI (blank)
Epivir lamivudine 3TC NRTI (blank)
Zerit stavudine d4T NRTI weight based dosing, do not combine w/ other "d" NRTI's (ddI, ddC) d/t additive periph neuropathy, pancreatitis, lactic acidosis, antagonism w/ AZT, lipoatrophy
Viread tenofovir TDF NtRTI Nephrotoxicity, Fanconi syndrome
Hivid zalcitabine ddC NRTI do not combine with other "d" NRTI's (d4T, ddI) d/t additive periph neuropathy, pancreatitis, lactic acidosis
Retrovir zidovudine AZT NRTI Take w/ food, hepatic dosing, neutropenia, anemia, lactic acidosis
Combivir zidovudine + lamivudine AZT + 3TC NRTI combo Not for initiation, not recommended for renal/hepatic failure
Epzicom abacavir + lamivudine ABC + 3TC NRTI combo Not for initiation, not recommended for renal/hepatic failure
Truvada tenofovir + emtricitabine TDF + FTC NtRTI + NRTI Not for initiation, not recommended for renal/hepatic failure (exception CrCl 30-59 1 tab q48h)
Trizivir zidovudine + lamivudine + abacavir AZT + 3TC + ABC NRTI combo Not for initiation, not recommended for renal/hepatic failure
Rescriptor delavirdine DLV NNRTI CYP-450 Inh, self-limiting rash
Sustiva efavirenz EFV NNRTI CYP-450 Inh/Ind CNS SE's, avoid high fat meals, avoid in pregnancy, self-limiting rash
Viramune nevirapine NVP NNRTI CYP-450 Ind, dose escalation on initiation, hepatotoxic, self-limiting rash, SJS, TEN
Agenerase amprenavir APV PI Soln contains EtOH, take w/ non-fatty meal, avoid vit E supplements, SJS
Reyataz atazanavir ATV PI Take with food, AVOID w/ PPI's, separate by 2-4 h from antacids and 12 h from H2 blockers, PR prolongation, hyperbilirubinemia, ONLY PI that is lipid-sparing
Lexiva fosamprenavir FPV PI Caution w/ sulfa allergy, SJS
Crixivan indinavir IDV PI Take on empty stomach, or with food if boosted by RTV, hypebilirubinemia, NEPHROLITHIASIS, AVOID w/ alprazolam/vardenafil
Kaletra lopinavir + ritonavir LPV/RTV PI Take with food, May increase AST/ALT >5x, Refrigerate (stable for 2 mos @ room temp), soln contains EtOH, AVOID w/ vori, amiodarone, propafenone, quinidine, pancreatitis
Viracept nelfinavir NFV PI Take w/ food, DIARRHEA (Recommend CaCO3/metamucil), AVOID w/ amiodarone, quinidine
Norvir ritonavir RTV PI Take w/ food, most potent CYP-450 Inh, mostly used as boosting agent, AVOID w/ vori, amiodarone, propafenone, quinidine, diazepan, zolpidem, vardenafil
Fortovase saquinavir-SGC SQV-SGC PI Take w/ food, refrigerate (stable for 3 mos @ room temp), AVOID w/ amiodarone, propafenone, quinidine, rifabutin
Inverase saquinavir-HGC SQV-HGC PI Not recommended as single PI, more tolerable than SGC, AVOID w/ amiodarone, propafenone, quinidine, rifabutin
Phase 3 trials (no brand name yet) tipranavir ??? NPPI (non-peptidic protease inhibitor) Low bioavailability, requires boosting w/ RTV
Fuzeon enfuvirtide T-20 Fusion inhibitor Rotate injection sites (upper arm, anterior thigh, abdomen), SQ injection, reconstituted must be used in 24h, refrigerated must be @ room temp before injection
Created by: trojanpharm
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