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Pharm Ch 27

Drugs for Angina Pectoris and Myocardial Infarction

acute coronary syndrome collection of symptoms that occur when a coronary artery is suddenly blocked
angina pectoris acute chest pain on physical or emotional exertion due to inadequate oxygen supply to the myocardium
atherosclerosis condition characterized by a buildup of fatty plaque and loss of elasticity of the walls of the arteries
coronary artery bypass graft (CABG) surgical procedure performed to restore blood flow to the myocardium by using a section of the saphenous vein or internal mammary artery to go around the obstructed coronary artery
coronary artery disease (CAD) narrowing of the coronary arteries
coronary heart disease narrowing of the coronary arteries that results in chest pain on exertion
glycoprotein IIb/IIIa enzyme that binds fibrinogen and von Willebrand's factor to begin platelet aggregation and blood coagulation
myocardial infarctions (MIs) blood clot blocking a portion of a coronary artery that causes necrosis of cardiac muscle
percutaneous coronary intervention (PCI) procedures by which obstructions in coronary arteries are removed
plaque fatty material that builds up in the lining of blood vessels and may lead to hypertension, stroke, myocardial infarction, or angina
silent angina partial blockage of a coronary artery that does not cause chest pain
stable angina type of angina that occurs in a predictable pattern, usually relieved by rest
unstable angina severe angina that occurs frequently and that is not relieved by rest
vasospastic (Prinzmetal's) angina type of angina in which the decreased myocardial blood flow is caused by spasms of the coronary arteries
beta-adrenergic antagonists decrease the heart rate and myocardial contractility; reduce cardiac output and workload
calcium channel blockers dilate arterial smooth muscle, reducing BP and decreasing cardiac workload; some also decrease the heart rate, reducing the workload on the heart, and dilate the coronary arteries
organic nitrates dilate veins, reducing the amount of blood returning to the heart; dilate the coronary arteries, bringing more blood to the myocardium