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Barbiturates
Treating seizures with barbiturates
Question | Answer |
---|---|
Barbiturates generally _______ the firing of CNS neurons. | depress |
_________ are organic compounds derived from barbituric acid. | Barbiturates |
The antiseizure properties of ________ were discovered in 1912, and this drug is still commonly prescribed for seizures. | phenobarbital |
Barbiturates generally have a _____ margin of safety. | low |
Barbiturates have a _____ potential for dependence. | high |
Barbiturates cause profound ________ _________. | CNS depression |
Barbiturates intensify the effects of _______ in the brain. | GABA |
__________ is able to suppress abnormal neuronal discharges without causing sedation. | Phenobarbital |
Phenobarbital is inexpensive, long acting, and produces a _______ _______ of adverse effects. | low incidence |
When phenobarbital is given orally, it may take _______ _______ to achieve optimum effects. | several weeks |
Phenobarbital is sometimes a preferred drug for the pharmacotherapy of _______ seizures. | neonatal |
Barbiturates are effective against all major seizure types except ________ seizures. | absence |
Other than phenobarbital, _________ is occasionally used for epilepsy treatment. | mephobarbital |
Mephobarbital (Mebaral) is converted to phenobarbital in the ______ and offers no significant advantages over phenobarbital. | liver |
________ (Mysoline) has a pharmocolgic profile similar to phenobarbital. | Primidone |
Primidone is among the drugs used effectively to ________ GABA action. | potentiate |
Barbiturates were once used on a regular basis to terminate the condition of _______ _________. | status epilepticus |
Intravenous administration of __________ is the preferred treatment for status epilepticus. | diazepam |
A common adverse effect of barbiturates is ________. | somnolence |
Serious adverse effects of barbiturates include agranulocytosis, dependence, Stevens-Johnson syndrome, angioedema, ________, respiratory depression, CNS depression, coma, and death. | laryngospasm |
Luminal is the trade name of which barbiturate? | phenobarbital |
What category of controlled substance does phenobarbital belong to? | IV |
Phenobarbital is a pregnancy category ____ drug. | D |
With overdose, _______ may cause severe respiratory depression, CNS depression, coma, and death. | phenobarbital (Luminal) |
Common side effects of phenobarbital include ________, vitamin deficiencies, and laryngospasm. | drowsiness |
Severe uncontrolled pain, pre-existing CNS depression, porphyrias, severe respiratory disease with dyspnea or obstruction, and glaucoma or prostatic hypertrophy are __________ of phenobarbital. | contraindications |
Phenobarbital should not be taken with ______ or other CNS depressants. | alcohol |
Alcohol and other CNS depressants ________ barbiturate action. | potentiate |
Barbiturates taken with alcohol and other CNS depressants increase the risk of life-threatening ________ _________ or cardiac arrest. | respiratory depression |
Phenobarbital _________ the metabolism of many other drugs, ________ their effectiveness. | increases; reducing |
Barbiturates may effect ________ tests and increase serum phosphatase. | bromsulphalein |
Phenobarbital is in the pharmacologic class _________; GABAa receptor agonist. | barbiturate |
Kava and valerian may potentiate ________ while taking barbiturates. | sedation |
There is no specific _______ for barbiturate overdose. | treatment |
_________ may be effective in facilitating removal of phenobarbital from the body. | Hemodialysis |
Removal of a barbiturate drug may be accomplished by _______ _______ or use of activated charcoal. | gastric lavage |
Barbiturate overdose treatment is supportive and consists mainly of _______ _________ and mechanical ventilation. | endotracheal intubation |
Treatment of _______ and ________ may be necessary with barbiturate overdose. | bradycardia; hypotension |