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ResU Pharm

Pharm Final/ ATI

inhibits serotonin re-uptake by allowing serotonin to stay at the neuron junctions SSRI
CNS depression, amnesia, Respiratory depression, cardiac arrest, paradoxical response, manifestations or withdrawal Adverse Effects of Benzodiazepine
(Contraindication) Erythromycin, St John's Wort, and grapefruit juice increases medication effects Non- Barbiturate Anxiolytic
Butabarbital, Amobarbital, Pentobarnital, Secobarbital,Mephobarbital Barbiturates- inhibits neuronal impulse conductions
Antidote for Benzodiazepine Toxicity Flumazenil
Pregnancy, uncontrolled pain, CNS depression, acute angle-closure glaucoma C/C: Benzodiazepines
Orthostatic hypotension, Anticholinergic effects, sedation, toxicity, decrease in seizure threshold, excessive sweating TCA- Tricyclics
PRIL ACE Inhibitors
PRESSIN Anti-Diuretic
PINE (exception) Diltiazem Calcium Channel Blockers
ZOLE Protein Pump Inhibitor
PAM, LAM (exception) Chlordiazepoxide, Clorazepate Benzodiazepines
Antidote is Phentolamine or Nifedipine MAO Inhibitors
GI distress, polyuria,weight gain, goiter, hypothyroidism, bradycardia,hypotension, electrolyte imbalance Lithium
blocks serotonin, dopamine, norepinephrine,histamine,acetylcholine Atypical Anti-Psychotics
neuroleptic malignant syndrome, muscle rigidity, change in consciousness levels, Anticholinergic effects, neuroendocrine effects Conventional Anti-Psychotic Adverse effects
Atomoxetine SNRI Drug
Paroxetine, Sertraline, Escitalopram, Fluvoxamine Selective Serotonin Reuptake Inhibitors
Increases levels of norepinephrine, serrotonin and dopamine in the CNS CNS Stimulant Methylphenidate
Slows sodium entering the neuron suppressing neuron firing and inhibiting GABA effects Hydantoins
GI effects, CNS effects, indicated for absent seizures ONLY Succinimides ex. Ethosuximide
treatment of myoclonic seizures Valproic Acid
Teratogenesis- birth defects, bone marrow suppression, bleeding disorder,liver disorder Carbamazepine
Tyramine enriched foods interact with what drug MAO INHIBITORS
aged cheese...peperoni...salami...avocado...figs...bananas...smoked fish...protein sauce...some wine are examples of what? Tyramine Enriched Foods
(Early Effects)Nausea, diaphoresis, tremor, fatigue, drowsiness, (Later Effects) Sexual Dysfunction SSRI's
use mouth not discontinue abruptly...avoid caffeinated beveraged Nursing Administration for SSRI's
Bruxism excessive teeth grinding
Androgens Suffix terone
Adverse effect of Ace Inhibitors Cough
Beta Blocker Suffix lol
Anti Viral Suffix vir
Thyroid Hormones contains "thy"
Antilipidemic Suffix statin
Haloperidol Blocks dopamine, acetylcholine, histamine,and norepinephrine receptors
Extrapyramdial side effects Acute dystonia, parkinsonism, akathisia, tardive dyskinesia
Atypical Antipsychotic -pine, done
Clozapine works by blocking serotonin and some dopamine receptors
CNS stimulation insomnia, restlessness, headaches, dizziness, blurred vision, aphasia, vomiting, depression
Ritalin Methylphenidate, ADHD
Proper use of a patch for Ritalin use on hip, 1 per day, no longer than 9 hrs.
Phenytoin and Lamotrigine adverse effects Teratogenic effect (cleft palate, heart defects)
Hydantoins control seizures by slowing entrance of sodium into neuron. Suppress neuron firing. inhibits effects,
Alkylating Agent (Chlorambucil) is typically used for... slow growing cancers
Used for absence seizures only Exthosumides
Treats partial seizures can also manage bipolar disorder Carbamazepines
Valproic acidic side effects GI effects, hepatoxicity, fatigue, abdominal pain, jaundice. pancreatitis, thrombocytopenia
Alkylating Agent non cell specific, most useful in the treatment of slow-growing cancers.
Chlorambucil Adverse effects tremors, muscle twitching, confusion, nausea, hepatotaxcity, bone marrow, suppression, sterility, more cancer
Priority nursing action for Benzodiazepine toxicity level of orientation
Antimetabolite agents are used for? rapidly growing neoplastic and normal cells
Methotrexate treats leukemia, psoriasis, rheumatoid, choriocarinomas
Doxorubicin adverse effect cardiac toxicity , alopecia, RED urine, fever, chills, rash, acute cardiac dysrythmias, cardiomyopathy
treats leukemia, cancers, and liposomal for AIDS associated Kaposi sarcoma Doxorubicin
Mitotic inhibitors Vincristine
Vincristine side effects Ataxia, cranial nerve, neuritic pain, muscle wasting, loss of hair, death, constipation, neuropathy
Tamoxifen is a drug used for breast cancer
causes hotflashes, rash, nausea, vomiting, vaginal bleeding, menstrual irregularities, edema, pain, CVA, pulmonary emboli Tamoxifen
Aspirin actions inhibit synthesis of prostaglandin of inflammatory rxn
NSAIDS Ibuprofen
Ibuprofen adverse effects headache, dizziness, somnolence, fatigue, rash, nausea, dyspepia, bleeding, constipation
Acetaminophen causes vasodilation
acetaminophen adverse effects do not take over 4 grams daily
Lidocaine actions CNS excitiation, hypotension, bradycardia, allergic, RXN, labor and delivery, spinal headache, urinary retention
direct-acting cholinergic agonist Bethanechol
Name a Chlonergic agonists pyridastgime
pyridastigime uses prevents CHK from inactivating ACh, increase ACh at receptor site
Pyridastigime administration take at the same time everyday, very low doses
Dopamine adverse effects Beta receptor acitvation in the heart can cause dysrhythmia, increase workload of heart, oxygen, necrosis
treatment of pain, arthritis, dysmenorrhea, juvenile arthritis Ibuprofen
Dopamine actions activation of receptors in the kidneys caused renal blood vessels to dilate, increases heart rate, MI contractility, AV nodes, vasoconstriction for shock
what do immune stimulants do Stimulate bone marrow to produce more white blood cells
Interferon Alfa-2b treatments Leukemia, warts, hep b malignant melanoma
Communicate between lymphocytes-stimulate cellular immunity & inhibit tumor growth Intereukins
T and B cell suppressor Cyclosporine
Cyclosporine uses block antibody of B cells and T cells
Cyclosporine A/E tremor, HTN, gum hyperplasia, diarrhea. hirsutism, acne, renal dysfunction
Measles, mumps, rubella activates an active immune rxn with the production of antibodies to the viruses
At what age are MMRs given 12-15 months
What is Immune Globulin used for provides passive, short term immunity, Prophylaxis after exposure to hep A., measles, varicella, or rubella
Immune Globulin adverse effects tenderness, muscle stiffness, rash, angiodema, vomiting, chills, fever, chest lightness
Treatment of specific renal carcinomas in adults Aldesleukin
Volatile liquids used in outpatient surgery Halothane
Very potent amnesiac used therapeutically, for diagnostic and endoscopic procedures Non Barbiturate Midazolam
emergence delirium, headaches,restlessness,anxiety,cardiac/resp depression,apnea,hiccups,salivation, rash Adverse Effects of Barbiturate Anesthetics
Preferred over ergot derivatives Triptans
Numbness, tingling in fingers/toes, pulselessness, weakness in legs, tachycardia, ergotism Ergot Derivatives
binds strongly to opioid receptors but doesn't activate them Narcotic Antagonist
Stimulates only specific opioid receptors Narcotic Agonist
drowsiness, dizziness, weakness, fatigue, diarrhea, hepatitis, myalgia, tachycardia, BP changes, rash and urinary frequency Adverse effects for Muscle Relaxants
Interferes with reflexes that causes muscle spasms in the CNS ----SPASMOLYTICS Baclofen
diminishes neuron excitability, decrease dopamine, centrally acting antagonist Anticholinergic Agent Diphenhydramine
CNS effects, atropine like effects, skin discoloration (livedo reticularis) Adverse effects of Dopaminergic Agent Amantadine
pain relief with opioid receptors Narcotics
Morphine Antidote Naloxone
Atropine is an anticholinergic should not be used in patients that have what? narrow angle glaucoma
atropine is the antidote for what ? Cholinergic drugs
how long is a medication holiday 10 days
RN Rationale for Orthostatic Hypotension Monitor BP and HR before administering meds and 1 HR after
Voiding before taking meds, increasing fluids( 2-3L daily), chewing sugar-free gum, exercise, sip water, wear sunglasses, high fiber diet Minimizing Anticholinergic effects
Common manifestation of a toxicity or reaction fever
Lithium A/E of fine hand tremors that interfere with motor skills can be resolved with Beta blockers-Propranolol
< 1.5 mEq/L Lithium Level withhold medication
1.5- 2.0 mEq/L Lithium Level Promote excretion
2.0- 2.5 mEq/L Lithium Level Gastric Lavage
2.5 and > Hemodialysis
Tetrogenic especially in 1st trimester Lithium
Obtain Lithium blood levels at what time Morning
_________ are best given slow and low Medications
Halperidol A/E--EPS, acute dystonia, Parkinsonism and Akathisia can be treated with Anticholinergic Agents
Diazepam Contraindications Sleep apnea, respiratory depression, glaucoma, liver disease, Hx of mental illness, Hx of substance abuse
After taking Benzodiazepines regularly Pt's need to be _______________ for several weeks tapered slowly
Tx: seizures, severe convulsions, anxiety, alcohol withdrawal, tetanus,pre-op sedation Benzodiazepine- Diazepam
C/C: glaucoma, psychosis,shock,coma,acute alcohol intoxication Diazepam
Tx: seizures, anxiety, sedative (hypnotic), pre-anesthesia Phenobarbital
A/E: CNS depression, hallucinations, headaches, vomiting, nausea, diarrhea, nightmares,insomnia, hypotension, bradycardia, ataxia, hyperkinesias, withdrawal, respiratory depression, Steven Johnson Syndrome, altered balance/proprioception Barbiturates- Phenobarbital
Phenytoin Tx: tonic-clonic seizures, control status epilepticus, seizures post neurosurgery
A/E: CNS depression, confusion, liver toxicity, cardiac arrthymias, decreased libido, urinary retention, decreased bone depression, gingival hyperplasia, Steven Johnson Hydantoin- phenytoin
Tx: Absent seizure Succinamides- ethosuximide
D 2 D: Anti-histamines, TCAs, barbituates, MAOIs, alcohol (Herbs)Chamomile, Kava, Valerian Benzodiazepines
R/I: admin. in slow doses, give w/food, monitor renal/liver funct, access anxiety B/A Tx, notify Provider if dose becomes ineffective, taper slow, Benzodiazepines
Depresses CNS by mimicking/enhancing GABA effects Benzodiazepines
D 2 D: Warfarin, Beta-blockers, corticosteroids,valproic acid, TCAs, theophyllines, contraceptives, MAOIs, Acetaminophen (Herbs) Kava, Valerian Barbituates
Unknown mechanism- mimics/enhances GABA Barbituates
C/C: pregnancy, uncontrolled pain, CNS depression, Hx of acute porphyria Barbituates
R/I: Assess sleep patterns, Avoid alcohol, monitor drug serum levels/Resp/CV dep, taper slow Barbituates
Butyrophenones, Atypical Anti-psychotics, Phenothiazines blocks dopamine, inhibits chemoreceptors in the medulla's trigger zone
Tx: Nausea, vomiting during surgery, or diagnostic procedures, anesthesia, psychosis, Tourette synd, explosive hyperactivity in children Haloperidol Droperidol
C/C: angle-closure glaucoma, CNS depression, may reduce seizure threshold, MI, Heart disease, benign prostatic hyperplasia, orthostatic hypotension prolonged QT (Droperidol) Butyrophenones, Atypical Anti-psychotics
A/E: EPS, Tardive kinesis, Neuroleptic Malignant synd, sedation, blurr'd vision, dry mouth, constipation, blood dyscrasias, photosensitivity, sunburn, heat intolerance Butyrophenones, Atypical Anti-psychotics
D 2 D: alcohol, CNS depression, antihypertensives, nitrates, antacids, neuroleptics Haloperidol, Droperidol
R/I: Avoid alcohol, driving, CNS depressants Butyrophenones
Haloleridol, Droperidol Anti-psychotics
Tx: psychosis, OCD, Bipolar, recurrent suicidal behavior Risperidone, clozapine. clomipramine, danzipine, loxapine
R/I: Assess mental status, monitor for EPS, orthostatic hypotension, RBC,WBC, avoid antacids w/i 1 hr of med intake, taper slow, avoid alcohol, use sunscreen and protective clothing Atypical- Anti-psychotic
Phenothiazines chlorapromazine, mesoridazine, fluphenazine, thioridazine, trifluoperazine, thietylperazine
Tx: psychosis, schizoaffective disorders, psychotic features w/ organic brain synd, nausea, vomiting Phenothiazines
R/I: Pink/ Reddish Brown urine, Monitor Pts QT Interval w/ thioridazine, consult provider before taking OTC drugs Phenothiazines
amitriptyline, Iimipramine, amoxapine, clomipramine,desipramine,doxepin,mirtazapine, nortriptyline protriptyline, bupropion, duloxetine, fluoxetine, maprotiline, nefazodone, trazodone,venlafaxine TCA's
Tx: Depression, Bipolar disorder, neuropathic pain, fibromyalgia, anxiety, insomnia Amitriptyline
A/E: Orthostatic Hypotension, Anticholinergic effects, Sedation, decreased seizure threshold, excessive sweating, cardiac dysrhythmias TCAs
Imipramine C/C: Pregnancy, seizure disorder, CV disease, diabetes, liver/kidney disorder, respiratory disorder, urinary retention/ obstruction, open angle glaucoma, benign prostatic hyperplasia, hyperthyroidism
D/D: MAOIs, St John's Wort, antihistamines, anticholinergic agents, alcohol, benzo's and opioids TCAs
MAOIs Phenelzine, Selegiline, Tranylcypromine, Isocarboxazid
blocks reuptake of serotonin and norepinephrine TCAs
blocks MAO increasing norepinephrine, dopamine, serotonin MAOIs
Tx: Bulimia nervosa, depression Phenelzine
A/E: Orthostatic Hypotension, CNS stimulation, Hypertensive crisis, rash MAOIs
C/C: diabetes, seizure disorder, pregnancy, HF, CVD, renal insufficieny Selegiline
D/D: TCAs, SSRIs, Meperidine, Vasopressors, caffeine, tyramine rich foods Phenelzine
R/I: Avoid OTC cold/decongestants, monitor B/P, restrict tyramine enriched foods MAOIs
Physotigmine TCA antidote
R/I: take meds as prescribed 2 establish therapeutic level and maintain, monitor for toxicity, give at bedtime, changes positions slowly, evaluate effectiveness TCAs
Treats Bipolar disprder, acute mania, return mania/depression, decreases incidence or suicide, alcohol disorder, bulimia nervosa, psychotic disorders Lithium carbonate
A/E; GI distress, fine hand tremors, polyuria, weight gain, renal toxicity, goiter/hyperthyroidism,bradydysrhythmia, hypotension, electrolyte imbalance Lithium
valproic acid, carbamazepine AED- Anti-epileptic drugs
SSRI Fluoxetine
C/C: Pregnancy, renal dysf, CVD, Na depletion, dehydration Lithium
D/D: NSAIDs, Diuretics, Anticholinergincs LITHIUM
Effexor SNRI
Tx: nerve pain, depression, anxiety Effexor
A/E: n/v, Anti-cholinerginc, CNS effects, libido/ ED, Serotonin synd SNRI-Effexor
increases phenytoin effects Alcohol, Diazepam, Cimetidine and Valproic Acid
Carbamazepine decrease phenytoin effects
Grapefruit juice inhibits metabolism in Carbamezipines
Phenytoin and phenobarbital decrease carbamazepine effects
Gabapentin Neuropathy
Ethosuximide, Valproic Acid and Lamotrigine Treats absent seizures
Created by: sparks5984



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