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Pharmacology

Neuromuscular Blockers

QuestionAnswer
Define NMB Cholinergic antagonists that act on the N2 receptors found on skeletal muscle
What are NMBs used for? Primarily used for skeletal muscle paralysis during: abdominal & thoracic surgery, mechanical ventilation, and intubation
Define Non-Depolarizing NMBs and how they work. Are competitive antagonists with ACh at the N2 receptor. Receptor stimulation keeps Na+ ion channels closed, so skeletal muscle cell depolarization DOES NOT occur.
Pavulon Pancuronium (Non-depol. NMB)
Zemuron Rocuronium (Non-depol. NMB)
Tracrium Atracurium (Non-depol. NMB)
Nimbex Cisatracurium (Non-depol. NMB)
Define Depolarizing NMBs and how they work. Acts like endogenous Ach, allowing depolarization, but prevents repolarization. Na+ channels are kept open for a longer than normal time. Results in "flaccid" paralysis. (short-acting & no reversal agent).
Anectine Succinylcholine (Depolarizing NMB)
Created by: bcarew2
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