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HIV medications

GENERIC NAMEBRAND NAME/Drug Target/FunFact
Enfuvirtide Fuzeon - Targets gp41 protein on HIV surface to block fusion [subQ BID, watch for pneumonia]
Maraviroc Selezentry - Blocks CCR5 on the surface of the CD4 cell to block Fusion. Requires tropism test to see if pt has CCR5. [change dose with 3a4 inhibitors/inducers, avoid st johns wort, hepatotixicity, heart problems, orthostatic-hypotension, URI
Abacavir Ziagen (ABC)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [hypersensitivity check HLA-B*5701]
Didanosine Videx (ddI)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [Empty stomach(needs alk), retinal pigmentation, eye exam q6-12 months, pancreatitis, peripheral neuropathy] (four Ps! peripheral neuropathy, pigmentation, pancreatitis, and please dont eat!)
Lamivudine Epivir (3TC)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [generally well tolerated, has different dosing for hepatitis B]
Stavudine Zerit (d4T)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [pancreatitis and peripheral neuropathy]
Zidovudine Retrovir (AZT, ZDV)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [DOVE into the bone marrow = BMS, take WITH food due to nausea, purple toe nails, myopathy, comes IV to be giving during birth)
Emtricitabine Emtriva (FTC)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [darkening palms and soles that is ok]
Delavirdine Rescriptor (DLV) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [ least potent, easy resistance causing cross resistance]
Efavirenz Sustiva (EFV) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [ false canabinoid test, vivid dreams, EMPTY STOMACH, 3A4 inducer and inhibitor, suicidality so not for mental health issues, avoid in 1st 8 weeks of pregnancy then ok)
Nevirapine Viramune (NVP) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [not recommended in treatment naive]
Rilpivirine Edurant (RPV) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [QT prolongation]
Etravirine Intelence (ETR) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [inhibits 2c9, 2c19, induce 3a4)
Tenofivir Viread (TDF) - NucleoTIDE Reverse Transcriptase Inhibitor [renal and hepatic - caution for both, osetoporosis, has lactic acidosis, can treat hep B... side effects from both nrti and nnrti]]
Raltegravir Isentress (RAL) - Integrase Inhibitor
Dolutegravir Tivicay (DTG) - Integrase Inhibitor
Elvitegravir Vitekta - Integrase Inhibitor
Indinavir Crixivan (IDV) - Protease Inhibitor [nephrolithiasis, empty stomach- only one, avoid in renal failure]
Lopinavir LPV + Ritonavir(RTV) = Kaletra (LPV/r) - Protease Inhibitor [solution has alcohol, has propylene glycol so not for newborns]
Nelfinavir Viracept (NPV) - Protease Inhibitor [ major GI issues, explosive diarrhea]
Ritonavir Norvir (RTV) - Protease Inhibitor [ 3a4 inhibitor, boosts the others, paresthesias]
Saquinavir Invirase (SQV) - Protease Inhibitor [has lactose so more GI upset]
Tipranavir Aptivus (TPV) - Protease Inhibitor [ has alcohol ("tipsy"), fatal hepatotoxicity, SULFA allergy issue, intracranial hemorrage]
Fosamprenavir Lexiva (FPV) - Protease Inhibitor [ SULFA allergy issue]
Atazanavir Reyataz (ATZ) - Protease Inhibitor [ requires acid for absorption, cardiac abnormalities, only PI without the lipid issues, never give with tenofovir (reduces effectiveness)]
Darunavir Prezista (DRV) - Protease Inhibitor [increases pravastatin, use fluvastatin instead, has SULFA allergy issue]
Combivir COMBO(NRTIx2): Zidovudine + Lamivudine
Trizivir COMBO(NRTIx3)+: Zidovudine + Lamivudine + Abacavir
Triumeg COMBO(NRTIx2+Integrase): Abacavir + Lamivudine + Dolutegravir
Epizicom COMBO(NRTIx2): Abacavir + Lamivudine
Truvada COMBO(NRTIx2): Tenofovir + emtricitabine TAF=DESCOVY
Atripla COMBO(NNRTI+NRTIx2): efavirenz + emtricitabine + tenofovir
Complera COMBO(NRTIx2+NNRTI): Emtricitabine + tenofovir +rilpivirine TAF = ODEFSEY
Stribild COMBO(Integrase+ 3A4 inhibitor+NRTIx2): elvitegravir + cobicistat + emtricitabine + tenofovir TAF = GENVOYA
Protease Inhibitor Class Effects GI, Lipodystrophy, hyperglycemia, hyperlipids (therefore increased MI), bleeding, hepatotoxicity (ALL through liver), all 3A4 inhibitors, take with food (except indinavir is empty stomach)
Cobicistat Tybost - 3A4 inhibitor used to boost protease inhibitors, approved for use with atazanavir and darunavir. Careful with liver
Nucleoside Reverse Transcriptase Inhibitors(NRTIs) Class Effects All are renal, headache, lactic acidosis and hepatic steatosis (LA and HS worst for zidovudine, stavudine, and didanosine), take without regard to meals except 2 exceptions
Non-Nucleoside Reverse Transcriptase Inhibitors(NNRTIs) Class Effects All are hepatic, hepatotoxicity and rash are big. all with food except efavirenz
Created by: naplexreviewgirl
 

 



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