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HIV medications
| GENERIC NAME | BRAND NAME/Drug Target/FunFact |
|---|---|
| Enfuvirtide | Fuzeon - Targets gp41 protein on HIV surface to block fusion [subQ BID, watch for pneumonia] |
| Maraviroc | Selezentry - Blocks CCR5 on the surface of the CD4 cell to block Fusion. Requires tropism test to see if pt has CCR5. [change dose with 3a4 inhibitors/inducers, avoid st johns wort, hepatotixicity, heart problems, orthostatic-hypotension, URI |
| Abacavir | Ziagen (ABC)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [hypersensitivity check HLA-B*5701] |
| Didanosine | Videx (ddI)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [Empty stomach(needs alk), retinal pigmentation, eye exam q6-12 months, pancreatitis, peripheral neuropathy] (four Ps! peripheral neuropathy, pigmentation, pancreatitis, and please dont eat!) |
| Lamivudine | Epivir (3TC)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [generally well tolerated, has different dosing for hepatitis B] |
| Stavudine | Zerit (d4T)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [pancreatitis and peripheral neuropathy] |
| Zidovudine | Retrovir (AZT, ZDV)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [DOVE into the bone marrow = BMS, take WITH food due to nausea, purple toe nails, myopathy, comes IV to be giving during birth) |
| Emtricitabine | Emtriva (FTC)- Nuceloside Reverse Transcriptase Inhibitor (NRTI) [darkening palms and soles that is ok] |
| Delavirdine | Rescriptor (DLV) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [ least potent, easy resistance causing cross resistance] |
| Efavirenz | Sustiva (EFV) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [ false canabinoid test, vivid dreams, EMPTY STOMACH, 3A4 inducer and inhibitor, suicidality so not for mental health issues, avoid in 1st 8 weeks of pregnancy then ok) |
| Nevirapine | Viramune (NVP) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [not recommended in treatment naive] |
| Rilpivirine | Edurant (RPV) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [QT prolongation] |
| Etravirine | Intelence (ETR) - Non-Nuceloside Reverse Transcriptase Inhibitor (NNRTI) [inhibits 2c9, 2c19, induce 3a4) |
| Tenofivir | Viread (TDF) - NucleoTIDE Reverse Transcriptase Inhibitor [renal and hepatic - caution for both, osetoporosis, has lactic acidosis, can treat hep B... side effects from both nrti and nnrti]] |
| Raltegravir | Isentress (RAL) - Integrase Inhibitor |
| Dolutegravir | Tivicay (DTG) - Integrase Inhibitor |
| Elvitegravir | Vitekta - Integrase Inhibitor |
| Indinavir | Crixivan (IDV) - Protease Inhibitor [nephrolithiasis, empty stomach- only one, avoid in renal failure] |
| Lopinavir | LPV + Ritonavir(RTV) = Kaletra (LPV/r) - Protease Inhibitor [solution has alcohol, has propylene glycol so not for newborns] |
| Nelfinavir | Viracept (NPV) - Protease Inhibitor [ major GI issues, explosive diarrhea] |
| Ritonavir | Norvir (RTV) - Protease Inhibitor [ 3a4 inhibitor, boosts the others, paresthesias] |
| Saquinavir | Invirase (SQV) - Protease Inhibitor [has lactose so more GI upset] |
| Tipranavir | Aptivus (TPV) - Protease Inhibitor [ has alcohol ("tipsy"), fatal hepatotoxicity, SULFA allergy issue, intracranial hemorrage] |
| Fosamprenavir | Lexiva (FPV) - Protease Inhibitor [ SULFA allergy issue] |
| Atazanavir | Reyataz (ATZ) - Protease Inhibitor [ requires acid for absorption, cardiac abnormalities, only PI without the lipid issues, never give with tenofovir (reduces effectiveness)] |
| Darunavir | Prezista (DRV) - Protease Inhibitor [increases pravastatin, use fluvastatin instead, has SULFA allergy issue] |
| Combivir | COMBO(NRTIx2): Zidovudine + Lamivudine |
| Trizivir | COMBO(NRTIx3)+: Zidovudine + Lamivudine + Abacavir |
| Triumeg | COMBO(NRTIx2+Integrase): Abacavir + Lamivudine + Dolutegravir |
| Epizicom | COMBO(NRTIx2): Abacavir + Lamivudine |
| Truvada | COMBO(NRTIx2): Tenofovir + emtricitabine TAF=DESCOVY |
| Atripla | COMBO(NNRTI+NRTIx2): efavirenz + emtricitabine + tenofovir |
| Complera | COMBO(NRTIx2+NNRTI): Emtricitabine + tenofovir +rilpivirine TAF = ODEFSEY |
| Stribild | COMBO(Integrase+ 3A4 inhibitor+NRTIx2): elvitegravir + cobicistat + emtricitabine + tenofovir TAF = GENVOYA |
| Protease Inhibitor Class Effects | GI, Lipodystrophy, hyperglycemia, hyperlipids (therefore increased MI), bleeding, hepatotoxicity (ALL through liver), all 3A4 inhibitors, take with food (except indinavir is empty stomach) |
| Cobicistat | Tybost - 3A4 inhibitor used to boost protease inhibitors, approved for use with atazanavir and darunavir. Careful with liver |
| Nucleoside Reverse Transcriptase Inhibitors(NRTIs) Class Effects | All are renal, headache, lactic acidosis and hepatic steatosis (LA and HS worst for zidovudine, stavudine, and didanosine), take without regard to meals except 2 exceptions |
| Non-Nucleoside Reverse Transcriptase Inhibitors(NNRTIs) Class Effects | All are hepatic, hepatotoxicity and rash are big. all with food except efavirenz |
Created by:
naplexreviewgirl
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