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Chemo Drug Classes
Chemotherapy Drugs by class
| Drug Name | Drug Class and Claim to Fame |
|---|---|
| Cisplatin (Platinol) | Alkylating Agent - nephrotoxic (give amifostine), ototoxic, most N/V of all chemo meds! |
| Carboplatin (Paraplatin) | Alkylating Agent - Analog of cisplatin... less nephrotoxicity, no need to give amifostine |
| Oxaliplatin (Eloxatin) | Alkylating Agent - Used in colorectal cancer (with 5-FU and leucovorin) |
| Busulfan (Myleran) | Alkylating Agent - Pulmonary fibrosis (check CXR), increased uric acid (use allopurinol) |
| Cyclophosphamide (Cytoxan) | Alkylating Agent - Hemorrhagic cystitis (blood in urine) MUST give MESNA to prevent, also causes alopecia |
| Ifosphamide (Ifex) | Alkylating Agent - analog of cyclophosphamide... has same issues. MUST give MESNA to prevent hemorrhagic cystitis |
| Temozolomide | Alkylating Agent |
| Carmustine | Alkylating Agent - Lipid soluble (used for CNS malignancies) |
| Lomustine | Alkylating Agent - Lipid soluble (used for CNS malignancies) |
| Streptozocin (Zanocar) | Alkylating Agent - used in pancreatic cancer (its that thing they use in studies to wipe out rat's pancreatic function!) causes type 1 diabetes because killing pancreas |
| Melphalan (Alkeran) | Alkylating Agent - fertility impairment |
| Mechlorethamine (Mustargen, Valchlor) | Alkylating Agent - extravasation is really bad and casues severe necrosis... use sodium thiosulfate if it occurs. Also causes fertility impairment |
| Altretamine (Hexalen) | Alkylating Agent - ovarian cancer, fertility impairment, if used with MAO-I can cause severe orthostatic hypotension |
| Dacarbazine | Alkylating Agent |
| Procarbazine (Matulane) | Alkylating Agent - Is an MAO-I inhibitor (think drug interactions and tyramine reaction). alcohol can cause disulfiram-like reaction |
| Bendamustine (Treanda) | Alkylating Agent - for CLL |
| Methotrexate | Antimetabolite - hepta/nephrotoxic, can cause crystal formation, alkalinize urine, pulmonary toxicity, photosensitivity, avoid pregnancy, mucositis, glucarpidase (Voraxaze) is drug that breaks it down when kidneys dont work |
| Fluorouracil (5-FU) (Adrucil) | Antimetabolite- increases INR, give at the same time as leucovorin to make 5-FU work better, hand/foot syndrome |
| Mercaptopurine (6-MP) (Purinethol) | Antimetabolite - drug interaction with allopurinol (need XO to be metabolized with allopurinol blocks - decrease 6-MP dose), Bactrim increases 6-MP, can cause hyperuricemia |
| Cytarabine (Cytosar) | Antimetabolite - cytarabine syndrome = (fever, myalgia, bone pain, CP, rash)can cause vision changes = use dexamethasone eye drops |
| Fludarabine (Fludara) | Antimetabolite - Major BMS ("aids in a bottle"), neurotoxicity, irreversible blindness |
| Capecitabine (Xeloda) | Antimetabolite - prodrug of 5-FU, PO dosage form, take after meals, cycle of 2 weeks on, 1 week off (breast cancer, colorectal cancer) |
| Cladribine | Antimetabolite |
| Pentostatin | Antimetabolite |
| Thioguanine | Antimetabolite |
| Hydroxyurea (Hydrea) | Antimetabolite |
| Bleomycin (Blenoxane) | Antibiotic- pulmonary fibrosis, hyperpigementation of skin, cumulative lifetime dose |
| Dactinomycin | Antibiotic - contraindicated in chicken pox/active herpes zoster |
| Daunorubicin | Antibiotic - turns everything red (urine/contacts), causes CHF (cardiotoxin due to iron), cumulative lifetime dose, apply cold compress if extravasates |
| Valrubicin | Antibiotic - turns things red, irritable bladder symptoms |
| Doxorubicin (liposomal and non-liposomal) | Antibiotic- turns everything red (urine/contacts), causes CHF (cardiotoxin due to iron), cumulative lifetime dose, apply cold compress if extravasates |
| Epirubicin | Antibiotic |
| Idarubicin | Antibiotic |
| Mitomycin | Antibiotic |
| Plicamycin | Antibiotic |
| Mitoxantrone (Novoantrone) | Antibiotic - turns things BLUE (blue urine, whites of eyes turn blue) |
| Docetaxel | Plant Alkaloid - hypersensitivity (premedicate), can cause fluid retension/pulmonary edema, check LFTs |
| Paclitaxel (Taxol) | Plant Alkaloid - hypersensitivity (premedicate), NO PVC, has ethanol in it so careful with disulfram drugs, contains castor oil |
| Etoposide | Plant Alkaloid - hypotension with rapid infusion |
| Teniposide | Plant Alkaloid - hypotension with rapid infusion |
| Irinotecan | Plant Alkaloid - I ran to the can - life threatening diarrhea, early forms can give atropine, late form can be lethal (loperimide, no max dose) |
| Topotecan | Plant Alkaloid - Topo ran to the can too - life threatening diarrhea, early forms can give atropine, late form can be lethal (loperimide, no max dose) |
| Vincristine (Oncovin, Marqibo) | Vinca Plant Alkaloid - most CNS toxicity, different brands have different doses. AS with all vincas: peripheral neuropathy and constipation |
| Vinblastine (Velban) | Vinca Plant Alkaloid - Bone marrow suppression. AS with all vincas: peripheral neuropathy and constipation |
| Vinorelbine (Navelbine) | Vinca Plant Alkaloid - alopecia. AS with all vincas: peripheral neuropathy and constipation |
| Imatinib mesylate (Gleevec) | Tyrosine Kinase Inhibitor (TKI) - strong 3A4 inhibitor |
| Tarceva (Erlotinib) | Tyrosine Kinase Inhibitor (TKI) - empty stomach |
| Lapatinib (Tykerb) | Tyrosine Kinase Inhibitor (TKI) - breast cancer |
| Nilotinib (Tasigna) | Tyrosine Kinase Inhibitor (TKI) - QT prolongation, for leukemia |
Created by:
naplexreviewgirl
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