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Chemo Drug Classes

Chemotherapy Drugs by class

Drug NameDrug Class and Claim to Fame
Cisplatin (Platinol) Alkylating Agent - nephrotoxic (give amifostine), ototoxic, most N/V of all chemo meds!
Carboplatin (Paraplatin) Alkylating Agent - Analog of cisplatin... less nephrotoxicity, no need to give amifostine
Oxaliplatin (Eloxatin) Alkylating Agent - Used in colorectal cancer (with 5-FU and leucovorin)
Busulfan (Myleran) Alkylating Agent - Pulmonary fibrosis (check CXR), increased uric acid (use allopurinol)
Cyclophosphamide (Cytoxan) Alkylating Agent - Hemorrhagic cystitis (blood in urine) MUST give MESNA to prevent, also causes alopecia
Ifosphamide (Ifex) Alkylating Agent - analog of cyclophosphamide... has same issues. MUST give MESNA to prevent hemorrhagic cystitis
Temozolomide Alkylating Agent
Carmustine Alkylating Agent - Lipid soluble (used for CNS malignancies)
Lomustine Alkylating Agent - Lipid soluble (used for CNS malignancies)
Streptozocin (Zanocar) Alkylating Agent - used in pancreatic cancer (its that thing they use in studies to wipe out rat's pancreatic function!) causes type 1 diabetes because killing pancreas
Melphalan (Alkeran) Alkylating Agent - fertility impairment
Mechlorethamine (Mustargen, Valchlor) Alkylating Agent - extravasation is really bad and casues severe necrosis... use sodium thiosulfate if it occurs. Also causes fertility impairment
Altretamine (Hexalen) Alkylating Agent - ovarian cancer, fertility impairment, if used with MAO-I can cause severe orthostatic hypotension
Dacarbazine Alkylating Agent
Procarbazine (Matulane) Alkylating Agent - Is an MAO-I inhibitor (think drug interactions and tyramine reaction). alcohol can cause disulfiram-like reaction
Bendamustine (Treanda) Alkylating Agent - for CLL
Methotrexate Antimetabolite - hepta/nephrotoxic, can cause crystal formation, alkalinize urine, pulmonary toxicity, photosensitivity, avoid pregnancy, mucositis, glucarpidase (Voraxaze) is drug that breaks it down when kidneys dont work
Fluorouracil (5-FU) (Adrucil) Antimetabolite- increases INR, give at the same time as leucovorin to make 5-FU work better, hand/foot syndrome
Mercaptopurine (6-MP) (Purinethol) Antimetabolite - drug interaction with allopurinol (need XO to be metabolized with allopurinol blocks - decrease 6-MP dose), Bactrim increases 6-MP, can cause hyperuricemia
Cytarabine (Cytosar) Antimetabolite - cytarabine syndrome = (fever, myalgia, bone pain, CP, rash)can cause vision changes = use dexamethasone eye drops
Fludarabine (Fludara) Antimetabolite - Major BMS ("aids in a bottle"), neurotoxicity, irreversible blindness
Capecitabine (Xeloda) Antimetabolite - prodrug of 5-FU, PO dosage form, take after meals, cycle of 2 weeks on, 1 week off (breast cancer, colorectal cancer)
Cladribine Antimetabolite
Pentostatin Antimetabolite
Thioguanine Antimetabolite
Hydroxyurea (Hydrea) Antimetabolite
Bleomycin (Blenoxane) Antibiotic- pulmonary fibrosis, hyperpigementation of skin, cumulative lifetime dose
Dactinomycin Antibiotic - contraindicated in chicken pox/active herpes zoster
Daunorubicin Antibiotic - turns everything red (urine/contacts), causes CHF (cardiotoxin due to iron), cumulative lifetime dose, apply cold compress if extravasates
Valrubicin Antibiotic - turns things red, irritable bladder symptoms
Doxorubicin (liposomal and non-liposomal) Antibiotic- turns everything red (urine/contacts), causes CHF (cardiotoxin due to iron), cumulative lifetime dose, apply cold compress if extravasates
Epirubicin Antibiotic
Idarubicin Antibiotic
Mitomycin Antibiotic
Plicamycin Antibiotic
Mitoxantrone (Novoantrone) Antibiotic - turns things BLUE (blue urine, whites of eyes turn blue)
Docetaxel Plant Alkaloid - hypersensitivity (premedicate), can cause fluid retension/pulmonary edema, check LFTs
Paclitaxel (Taxol) Plant Alkaloid - hypersensitivity (premedicate), NO PVC, has ethanol in it so careful with disulfram drugs, contains castor oil
Etoposide Plant Alkaloid - hypotension with rapid infusion
Teniposide Plant Alkaloid - hypotension with rapid infusion
Irinotecan Plant Alkaloid - I ran to the can - life threatening diarrhea, early forms can give atropine, late form can be lethal (loperimide, no max dose)
Topotecan Plant Alkaloid - Topo ran to the can too - life threatening diarrhea, early forms can give atropine, late form can be lethal (loperimide, no max dose)
Vincristine (Oncovin, Marqibo) Vinca Plant Alkaloid - most CNS toxicity, different brands have different doses. AS with all vincas: peripheral neuropathy and constipation
Vinblastine (Velban) Vinca Plant Alkaloid - Bone marrow suppression. AS with all vincas: peripheral neuropathy and constipation
Vinorelbine (Navelbine) Vinca Plant Alkaloid - alopecia. AS with all vincas: peripheral neuropathy and constipation
Imatinib mesylate (Gleevec) Tyrosine Kinase Inhibitor (TKI) - strong 3A4 inhibitor
Tarceva (Erlotinib) Tyrosine Kinase Inhibitor (TKI) - empty stomach
Lapatinib (Tykerb) Tyrosine Kinase Inhibitor (TKI) - breast cancer
Nilotinib (Tasigna) Tyrosine Kinase Inhibitor (TKI) - QT prolongation, for leukemia
Created by: naplexreviewgirl



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