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Cardiovascular I slides for Medical Pharmacology Final

Caused by the presence of a septal defectal on the ventricles. Fallot Tetralogy
Cardiac Muscle Contraction: Phase characterized by the fast influx of Sodium. Phase 0: Upstroke
What happens Phase 1 (partial repolarization) of Cardiac Muscle Contraction? Inactivation of Sodium channels and rapid opening of Potassium channels.
Why cardiac potential does not change quickly during Plateau phase (Phase 2)? Due slow Calcium influx and slow outward leak of Potassium.
Why the action potential decrease rapidly in Phase 3 Repolarization? Because of Calcium channels are blocked and Potassium channels are opened.
Which hormone is released by the Kidney when blood pressure is low? Renin
What would be a symptom of right heart failure? Peripheral edema
Which enzyme is blocked that converts angiotensin I to angiotensin II to lower blood pressure? ACE
What does aldosterone do, would you want an agonist or antagonist? Promotes salt and water retention, antagonist
Which type of beta blockers are more effective and why? Beta 1, more specific for cardiovascular
Why would someone get a calcium channel blocker? Slow conduction of AV node
What is the role of Renin? Converts Angiotensinogen into Angiotensin I
Which hormone participates in the convertion of Angiotensinogen into Angiotensin I? Renin
What is the role of Aldosterone in the body? Water and salt retention -> increase bloody pressure.
Renin release can also be stimulated by which receptor agonist? Beta receptor agonists
What are the side effects of ACE inhibitors? Hypotension, Hyperkalemia, Angiodema and Dry cough.
Which receptor-blockers can decrease heart rate? Beta blockers
What class of drug scan facilitate Calcium inward on the heart? What is it consequence? Ionotropic drugs. Promote contractility, but can cause arrhythmia
What is the general order for Heart Failure Therapy? Diuretics → ACE inhibtors → Beta-blockers → Digoxin
Digoxin is a ___________ drug (class of drug), that increase contractility of heart through _______ influx. Digoxin is a IONOTROPIC drug (class of drug), that increase contractility of heart through CALCIUM influx
Created by: 100001573433065



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