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Pharmacokinetic Quiz
Question | Answer |
---|---|
What is a competitive antagonism, and give examples? | receptor antagonist that binds to a receptor. the antagonist will compete with available agonist for receptor binding sides on the same receptor. ex: Naloxone |
what is a paradoxical reaction? | unexpected excessive or opposite response. Ex: pain caused by a pain relief medication |
what is synergy? | using two medications each do two different things and do not affect each other. Ex: Valium and Dilaudid |
explain role of first pass metabolism? | Concentration of a drug is greatly reduced before it reaches the circulation before the liver. ex: morphine,Demerol,lidocaine |
What is the CYP 450 Pathway | Enzyme with a wavelength of 450 nanometers. Large # of enzymes play a major role in biotransformation of drugs |
What is Second messenger cAMP? | intracelluar signaling molecules released by the cell to trigger physiological changes such as proliferation,differentiation.Ex: cyclic AMP. Cyclic GMP, inositol triphosphate, diacylalycerol, and calcium. |
What is Biotransformation? | Takes place in the liver, it is a process of detoxification the end products are metabolites |
What is Pharmacokinetic? | How the drug is eliminated by the body |
What is pharmacodynamics? | Drug action at the molecular and whole organismlevel |
What is ED50? | Effective Dose- Does that will produce 50% of maximal response |
What is LD50? | Lethal dose, dose that will kill 50% of animal tested on |
What is therapeutic index or window? | (TI)= LD/ED. The higher the index the better gives estimate of relative safety |
What is T1/2 | Half life-time for drug level in blood to decrease by 50% |
What is Agonist? | A drug that stimulates a cell receptor |
What is Antagonists? | a drug that inhibits the action of an agonist (binds with the receptor site but does not activate them) |
What is stacking? | The delayed, cumulative effect of repeated doses of a drug |
What is piggybacking? | putting an IV bag into a main line by another infusion in the line |
What is Teratogenic effects? | A drug which causes severe congenital defects |
What is Bolusing? | A drug given in a greater amount than followed by a maintenance dose is given |
what is Chelation? | A particular way that ions and molecules bind metal ions |
What is Invitro? | In a human |
What is invivo? | in glass |
What is Drug resistance or tolerance? | The resistance of drugs within the body to let the drug do what its suppose to do |
What is drug titration? | regulating a dose based on a sliding scale of values. |
What is Protein binding of drugs in the blood? | The ability of proteins to form bonds with other substances |
What is Action of water-soluble drugs on receptors? | receptors binding to receptors on the surface of the the target cell. The chemical reaction activates enzymes inside the cell. |
What is action of lipid soluble drugs on cells? | doesn't like water, and cannot move through a cell very easily. |
What is the mechanisms of reversal agents or antidotes? | the actual process bu which a drug alters a cell or body fluids. |
What is a loss of effectiveness through receptor up or down regulation? | Chronic stimulation by agonist tends to decrease receptor #of receptor response. the nucleus recognizes that this much stimulation is not normal and pulls receptors into the cell as a protective mechanism to prevent over stimulation. |
What is Enzyme stimulation or inhibition | Drugs may increase production of enzymes. Ex: bronchodilation,.lipolysis |
what are the interactions with neurotransmitters? | Change rte of nerve impulse conduction. Ex: Prozac |