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Top 200 #10

ClassBrandGenericIndicationDose FormRouteAdult DosePed. DoseMOA
Antiretroviral Agent; Protease Inhibitor Prezista Darunavir HIV Infection Oral Susp: 100mg/ml; Oral Tablet: 75, 150, 400, 600, 800mg Oral Tx naive: 800mg with ritonavir 100mg QD with food; Tx experienced: 600mg with ritonavir 100mg BID 3YO+: Tx with no darunavir resistance: darunavir 35mg/kg with ritonavir 7mg/kg QD; Tx with darunavir resistance: 20mg/kg with ritonavir 3mg/kg BID HIV-1 protease inhibitor that prevents the cleavage of Gag and Gag-Pol polyprotein yielding immature, noninfectious virus
Antirheumatic; Immune Modulator Orencia Abatacept Juvenile idiopathic arthritis; RA (moderate to severe) IV Powder for Soln: 250mg; SubQ Soln: 125mg/ml IV, SubQ SubQ: 125mg once weekly; IV: Initial dose, doses at week 2 and 4, then every 4 wk 6YO+: IV dose varies based on weight, same interval as adult CTLA-4 Ig – demonstrates anti-inflammatory effects by down regulating T cell activation
Bile Acid Sequestrant; Phosphate Binder Renvela Sevelamer End Stage Renal Disease( hyperphosphatemia) Oral Powder for Susp: 0.8gm/packet, 2.4gm/packet;Oral Tablet: 800mg Oral Varies based on serum phosphorus level 800-1600mg TID w/ meals N/A Binds with phosphate molecules through ionic and hydrogen bonding and reduces phosphate absorption in the dietary tract, thereby lowering the serum phosphate concentration
Cartilaginous Defect Repair Agent Synvisc Hyaluronate (Hylan Polymers A & B) Osteoarthritis of knee Inj. Soln: 8mg/ml Intra-articularly Inject 16mg(2mL) into the knee once weekly x 3 weeks N/A 21YO+ Derivative of the natural substance, hyaluronan, that lubricates and enables the joint to work properly
Erythropoietic; Hematopoietic, Colony Stimulating Factor Aranesp Darbepoetin alfa Anemia (due to chemotherapy or of chronic renal failure) Inj. Soln: many strengths 10mcg/0.4ml – 500mcg/ml SubQ, IV once weekly dosing to every 3-week dosing 1YO+: Varies, once weekly - every 2 weeks Binds to progenitor stem cells stimulating the production/ differentiation of RBCs
Erythropoietic; Hematopoietic, Colony Stimulating Factor Epogen; Procrit Erythropoietin (Epoetin Alfa) Anemia (due to chemo, chronic renal failure, zidovudine ADR); surgical procedure Inj. Soln: 2000, 3000, 4000, 10000, 20000, 40000 (Procit only) U/ml SubQ, IV 50-100 U/kg 3 times weekly; 40,000U/wk Cancer patient 5YO+: 60,000 U/wk ; Dialysis pt 1MO+: 50U/kg 3x weekly Stimulates the division and differentiation of committed erythroid progenitors in the bone marrow increasing RBC production
Immunological Agent; Monoclonal Antibody Herceptin Trastuzumab Breast cancer (HER2 overexpression); gastric cancer; malignant neoplasm of cardio-esophageal junction of stomach IV Powder for Soln: 440mg IV BREAST CANCER(adjuvant Tx): 2-4mg/kg IV every 3 weeks; Breast cancer (metastatic): 2-4mg/kg/wk. GASTRIC CANCER: 6-8 mg/kg IV every 3 wks until disease progression. All are infused over 30-90 mins N/A Binds to extracellular domain of the HER2 protein which is overexpressed in 25-30% of primary breast cancers; inhibits the growth of tumor cells & mediates ADCC
Monoclonal Antibody, Angiogenesis inhibitor, Vascular Endothelial Growth Factor (VEGF) inhibitor Lucentis Ranibizumab Diabetic macular edema (DME); exudative age-related macular degeneration (AMD); macular retinal edema Intraocular Soln: 0.3mg/0.05ml, 0.5mg/0.5ml Intra-vitreal Injection Dose varies 0.3-0.5 mg once a month N/A Inhibits the human VEGF-A by binding to its active forms thereby preventing ocular angiogenesis by VEGF-A
Thyroid Supplement Synthroid; Levoxyl; Levothroid; Unithroid; Levothyroxine Hypothyroidism; Myxedema coma; TSH suppression IV Powder for Soln: 100, 200, 500mcg; Oral Tablet: 25, 50, 75, 88, 100, 112, 125, 137, 150, 175, 200, 300mcg Oral, IV 1.7mcg/kg/day. Severe: 12.5-25mcg/day; TSH suppression: 2mcg/kg/day Hypothyrodism: 0mo-12yo: 10-3 mcg/kg/day T3 and T4 are thought to act by binding to thyroid receptor proteins attached to DNA, thus activating gene transcription and protein synthesis
Thyroid Supplement Cytomel Liothyronine Hypothyroidism; Myxedema coma; Thyroid suppression; Simple Goiter Oral Tablet: 5, 25, 50mcg IV Soln: 10mcg/mL Oral, IV Hypothyroidism: 25-75mcg/day; Myxedema; 50-100mcg/day few months old: 20mcg/day; 1yo: 50 mcg/day; 3yo+: adult dosage Synthetic natural thyroid hormone that stimulates O2 consumption by most body tissues. This accelerates BMR, and metabolism of carbs, proteins, and lipids.
Thyroid Supplement Armour Thyroid Levothyroxine/Liothyronine (Thyroid) Hypothyroidism; Thyroid stimulating hormone suppression Oral Tablet: 15, 30, 60, 90, 120, 180, 240, 300mg Oral Initial Dose: 15-30mg/day Maintenance: 60-120mg/day 0mo-12yo+: 7.5-90mg/day T3 and T4 are thought to act by binding to thyroid receptor proteins attached to DNA, thus activating gene transcription and protein synthesis
Nonbarbiturate Hypnotic Ambien; Ambien CR; Edluar; Intermezzo; Zolpimist Zolpidem Insomnia Oral Tab: 5,10mg; ER Tab: 6.25,12.5mg; SL Tab: Edluar: 5, 10mg, Intermezzo: 1.75, 3.5mg; Oral Mist Spray: 5mg/0.1ml or 5mg/ACT; (AmbienPak:10mg/tab) Oral, Sublingually Intermezzo:1.75mg/women, 3.75 mg/men. Women: 5mg, 6.25 mg . Men: 10mg, 12.5 mg All are taken immediately before bedtime USE LOWEST DOSE POSSIBLE N/A Binds the benzodiazepine (BZ) receptor subunit of the GABA-A receptor complex
Nonbarbiturate Hypnotic Lunesta Eszopiclone Insomnia Oral Tablet: 1, 2, 3mg Oral 1-3 mg immediately before bedtime; Max: 3mg N/A Believed to bind to or interact allosterically at the GABA-receptor complex domain
Antibiotic, cyclic lipopeptide Cubicin Daptomycin Bacteremia assoc. with intravascular line, bacteria due to S. aureus; infection of skin and/or subQ tissue; IV Powder for Soln: 500mg IV skin infection: 4mg/kg/day x 7-14 days; Bacteremi(S.aureus): 6mg/kg/day x 2-6 wks; Bacteremia (MRSA): 6-8mg/kg/day N/A Binds to bacterial cell membranes and causes cell death by inducing rapid depolarization of the membrane potential, leading to disruption of DNA, RNA, and protein synthesis
Antimetabolite; Antineoplastic Agent Xeloda Capecitabine Colon cancer; metastatic breast cancer; metastatic colorectal cancer, Duke stage C colon cancer Oral Tablet: 150, 500mg Oral 1250mg/m^2 BID x 2 wk, followed by 1 wk rest, then 3wk cycle (x total of 24 wks) N/A See Word Doc (too long)
Antineoplastic Agent; Tyrosine Kinase Inhibitor Gleevec Imatinib Mesylate Leukemia (various forms); dermatofibrosarcoma protuberans; GI stromal tumor; hypereosinophilic syndrome; myelodysplastic syndrome (with PDGFR); myeloproliferative disorder (with PDGFR); systemic mast cell disease Oral Tablet: 100, 400mg Oral 100-600mg QD 1YO+ 340mg/m^2 per day Max: 600mg/day Inhibits the bcr-abl tyrosine kinase and thus suppresses proliferation and promotes apoptosis in bcr-abl positive cell lines and fresh leukemic cells from Philadelphia chromosome positive chronic myeloid leukemia
Antiretroviral, Reverse Transcriptase Inhibitor Atripla Efavirenz/ Emtricitabine/ Tenofovir HIV infection Oral Tablet: 600/200/300mg Oral 1 tab QD on an empty stomach 12YO+ and weigh 40kg: 1 tab QD on an empty stomach See Word Doc (too long)
Antiretroviral, Reverse Transcriptase Inhibitor Truvada Emtricitabine/ Tenofovir HIV Infection; also prophylaxis Oral Tablet: 200/300mg Oral 1 tab QD on an empty stomach 12YO+ and weigh 35kg+: 1 tab QD on an empty stomach See Word Doc (too long)
Antiretroviral; Antiviral; Protease Inhibitor Reyataz Atazanavir HIV Infection Oral Capsule: 150, 200, 300mg Oral Packet: 50mg Oral Typical dose: 300mg with 100mg ritonavir QD w/ food Patients who can't tolerate ritonavir: 400mg QD w/ food 3Mo+: Packet: 200-250mg with 80 mg ritonavir QD w/food 6yo+: Cap: 150-300mg with 100mg ritonavir QD w/food 13yo+: and can't tolerate ritonavir: 400mg QD w/food Azapeptide HIV-1 protease inhibitor, prevents formation of mature virions by selectively inhibiting the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells
Antiretroviral Agent; Integrase Inhibitor Isentress Raltegravir HIV Infection Oral Tab: 400mg Chewable Tab: 25, 100mg Oral Powder for Suspension: 100mg/packet Oral 400mg BID 4wk-older and <25kg: Chewable: 75-150mg BID. Oral susp: 20-100mg BID >25kg: 400mg tab BID >25kg: chewable: 150-300mg BID Inhibits viral DNA insertion into the host’s cellular genome; inhibits HIV-1 integrase inhibitor
Created by: scottamus123