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Pharmacology

Veterinary Pain/Inflammation

QuestionAnswer
NSAID, Aspririn, ASA
NSAID, Phenylbutazone Butequene
NSAID, flunixin Banamine
NSAID, ketoprofen Anafen
NSAID, tofenamic acid Tolfedine
NSAID, meloxicam Metacam
NSAID, carprofen Rimadyl
NSAID, meclofenamic acid Arquel
NSAID, vedaprofen Quadrisol
NSAID, dipyrone Dipyrone
NSAID,acetominophen (not a true NSAID, no anti-inflammatory effects, only analgesic) Tylenol
NSAIDS in general weak acids, protein bound, absorbed in stomach, additive effect (too much = bad), GIT ulceration (v/d, blood in stool), be careful in liver/kidney disease patients, cats are sensitive and cannot form glucaronic acid (CAUTION in Cats)
NSAID Side effects decrease platelet aggregation, bleeding, GIT ulceration, nephrotoxic in horses and bone marrow suppression in cats, Rimadyl (beware liver effects)
DMSO, antiinflammatory increases absorption of other drugs (vehicle), give topical/IV, freezes at 18 degrees C, wear gloves when using, gives garlic odor and taste when touching, scavenges free radicals
Polysulfated glycosaminoglycans Adequan, very expensive chondroprotective agents, variable efficacy, used in degenerative joint disease
Hyaluronic acid Hyonate, chondroprotective
Pentosan polysulfate Na Cartrophen, chondroprotective
Methocarbamol Robaxin, muscle relaxant, reduce muscle hyperactivity by blocking nerves in the spinal cord
Corticosteroids in general pruritis, dermatitis, arthritis, sprains, muscle soreness, rheumatoid arthritis, allergies, cancer
Corticosteroids SE Pu/Pd, decreased healing rate, polyphagia, weight gain, abnormal behavior, panting, increased activity, GIT bleeds, iatrogenic cushings, laminitis
Corticosteroids CI Acute and chronic bacterial infections, CHF, diabetes, chronic nephritis, pregnancy (abortions)
Hydrocortisone Forte-Topical, short acting
Cortisone Short acting
Prednisone Predsone5, intermediate acting
Prednisolone Vanectyl-P, Intermediate acting
Methylprednisolone Intermediate acting
Triameinolone Panalog, intermediate acting
Dexamethasone Long acting
Betamethasone Long acting
Flumethasone Long acting
Corticosteroid uses Inflammatory = low dose, immunosuppressive = moderate dose, shock = high dose
Opioids general block receptors in brain, spinal cord and peripheral tissues, antitussive, respiratory depressants, increase IOP, vomiting, defecation, miosis (dogs), mydrasis (cats), bradycardia, panting, excitement, histamine release
Opioids SE constipation, respiratory depression, sedation, excitement (cats and horses), MUST KEEP METICULOUS RECORDS
Morphine Infumorph
Meperidine Opioid
Hydromorphone Diluadid
Fentanyl Dergesic
Butorphanol Torbugesic, Torbutrol
Antihistamines general Block H1 receptors, SE= drowsy, excitable (cats and horses), weakness, dry MM, reduce motion sickness (H1 receptors in inner ear)
Diphenhydramine Benadryl, CI= bladder obstruction, don't use with other drugs, AE = drowsy, dizzy, nausea, dry mouth, avoid SQ, anxiety
Dimenhydrinate Gravol, CI= glaucoma, chronic lung disease, AE= drowsy, dry mouth, nausea, CNS depression
Terfenadine Apoterfenidine, don't use with anti-fungals
Chlorpheniramine Cortabs, dermatitis
Prednisolone trimeprazine tartrate Vanectyl-P, antipruritic, dermatitis
Created by: jtwilks