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Top 200 #7

ClassBrandGenericIndicationsDose FormsRouteAdult DosingPed. DosingMOA
Antidepressant; SSRI Zoloft Sertraline Major depressive disorder; OCD; panic disorder; PTSD; premenstrual dysphoric disorder; social phobia Oral Soln: 20mg/ml; Oral Tablet: 25, 50, 100mg Oral Varies 6YO+ OCD treatment 6-12YO: 25mg/day; 13-17YO: 50mg/day… Treatments in AM or PM, may increase at 1 week intervals to max of 200mg/day SSRI Enhance serotonin activity in the CNS
Antidepressant; SNRI Cymbalta Duloxetine Diabetic peripheral neuropathy (pain), fibromyalgia, anxiety disorder, major depressive disorder, musculoskeletal pain (chronic) Oral Capsule (Delayed Release): 20, 30, 60mg Oral Varies Max: 120mg/day 7YO+ Max: 120mg/day SNRI Serotonin, NE reuptake inhibitor
Antidepressant; SNRI Effexor; Effexor XR Venlafaxine Generalized anxiety disorder, major depressive disorder, panic disorder, social phobia ER Capsule: 37.5, 75, 150mg; Oral Tablet: 25, 37.5, 50, 75, 100mg; ER Tablet: 37.5, 75, 150, 225mg Oral 37.5-75mg/day, may increase by 75mg per day every 4 days Max ER: 225mg/day Max IR: 375mg/day N/A SNRI It inhibits neuronal Serotonin, NE, and DA reuptake.
Antidepressant; Triazolopyridine Desyrel Trazodone Depression IR Tablet: 50, 100, 150, 300mg; ER Tablet: 150, 300mg Oral IR Tablet: 150mg QD, may increase by 50mg/day ever 3 to 4 days (max of 600mg/day) ER Tablet: 150mg QPM or HS, may increase by 75mg/day every 3 days (max 375mg/day) N/A Selectively inhibits neuronal reuptake of serotonin and acts as an antagonist at 5-HT-2A/2C serotonin receptors; also has α-1 antagonistic property which is associated with postural hypotension
Tricyclic Antidepressant Elavil Amitriptyline Depression Oral Tablet: 10, 25, 50, 75, 100, 150mg Oral 50-100mg HS (max 150mg/day for outpatients and 300mg/day for inpatients) 12YO+: 10mg TID and 20mg HS Promotes neuronal activity by blocking the membrane pump mechanism which is responsible for the absorption of serotonin and NE in serotonergic & adrenergic neurons
Antimigraine; Serotonin Receptor Agonist (5-HT1) Imitrex Sumatriptan Migraine, Cluster HA Oral Tablet: 25, 50, 100mg; SubQ Soln: 4mg/0.5ml, 6mg/0.5ml Nasal Soln: 5mg/act 20mg/act Oral, SubQ, Nasal Tablets: 25-100mg initially, may repeat after 2 hrs if needed (max 200mg/day); SubQ: 6mg, repeat in 1 hr if needed (max of 6mg/dose and 12mg/24hrs) Nasal: 5-20mg, may repeat after 2 hrs. (max 0f 40mg/24hrs) N/A Selective 5-HT1 receptor agonist, stimulating vasoconstriction in the basilar artery & blood vessels of the Dura mater
CNS Agent; N-Methyl-D-Aspartate Receptor Antagonist (NMDA antagonist) Namenda, Namenda XR Memantine Alzheimer’s Disease (moderate to severe) Oral Soln: 2mg/ml; Oral Tablet: 5 or 10mg; ER Oral Capsule: 7, 14, 21, 28mg Namenda Titration pack: 49tabs (28x5mg, 21x10mg) Namenda XR Titration Pack: 28caps (7x7mg, 7x14mg, 7x21mg, 7x28mg) Oral IR Tablets: initial = 5mg/day, may increase at minimum of 1 week increments (5mg BID, then 10+5mg, then 10mg BID); target dose is 20mg QD (or 10mg BID) ER Capsules: initial = 7mg/day, may increase like IR; target & max dose is 28mg/day N/A Low to moderate affinity noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist
CNS Agent; NE Reuptake Inhibitor Strattera Atomoxetine ADHD Oral Capsule: 10, 18, 25, 40, 60, 80, 100mg Oral 40mg/day; increase after a minimum of 3 days to target dose of approx. 80mg/day (max dose is 100mg/day) Varies 6YO+ Selective NE reuptake inhibitor
Anticonvulsant; CNS Agent; Fructopyranose Sulfamate Topamax Topiramate Lennox-Gastaut syndrome (adjunct); migraine (prophylaxis); partial seizure; tonic-clonic seizure Oral Capsule: 15 or 25 mg; Oral Tablet: 25, 50, 100, 200mg; ER Capsule: 25, 50, 100, 150, 200mg Oral Varies Varies Exact is unknown, but there is blockage of voltage-gated Na+ channels, augmentation of GABA-A activity, AMPA/kainite antagonism of glutamate receptor, and inhibition of carbonic anhydrase enzyme (isozymes 2 & 4)
Aminoketone; Antidepressant; Smoking Cessation Agent Wellbutrin (SR, XL); Zyban Bupropion Depression; major depressive disorder; smoking cessation assistance Oral Tablet: 75 or 100mg; ER 12hr Tablet: 100, 150, 200mg; ER 24hr Tablet: 150 or 300mg Oral Varies N/A Weakly inhibits the neuronal uptake of dopamine and NE, but doesn’t inhibit monoamine oxidase or the reuptake of serotonin
Smoking Cessation Agent Chantix Varenicline Smoking cessation assistance Oral Tablet: 0.5mg, 1mg Oral Days 1-3: 0.5mg qd Days 4-7: 0.5mg bid Days 8-end: 1mg bid N/A Produces agonist activity at a subtype of nicotinic receptor, while preventing nicotine binding to alpha-4-beta-2 receptors
Immunological Agent; Monoclonal Antibody Avastin Bevacizumab Cervical cancer, Glioblastoma multiforme of brain; metastatic colorectal cancer; metastatic renal cell carcinoma; nonsquamous non-small cell lung cancer, ovarian cancer IV Soln: 400mg/16ml 100mg/4ml (25mg/ml) IV Varies N/A Recombinant humanized monoclonal IgG1 antibody, binds to vascular endothelial growth factor (VEGF) & inhibits the interaction of VEGF to Flt1 & KDR receptors on the surface of endothelial cells.
Immunological Agent; Interferon, Beta Avonex; Rebif Interferon beta-1α Multiple sclerosis (relapsing forms) IM kit: 33mcg; kit: 30mcg/0.5ml; SubQ Soln: 22mcg/0.5ml, 44mcg/0.5ml IM, SubQ Varies Titrate Dosing N/A Purified glycoprotein which has identical amino acid sequence as natural fibroblast-derived human interferon beta
Antipsychotic Abilify Aripiprazole Autistic, bipolar, major depressive disorder, schizophrenia ODT: 10 or 15mg; IM Soln: 9.75mg/1.3ml; Oral Soln: 1mg/ml; Oral Tablet: 2, 5, 10, 15, 20, 30mg; IM Powder for Susp: 300mg/vial, 400mg/vial Oral, IM Varies Bipolar max: 30mg/day MDD max: 15mg/day Varies 6-17YO (autistic) 6-17YO (Tourette) 10-17YO (bipolar) 13-17 (Schizo.) Exhibits relatively high affinity for dopamine D2 & D3 receptors and serotonin 5-HT1A & 5-HT2A; (partial agonist activity at D2 and 5-HT1a and antagonist activity at 5-HT2A
Antipsychotic; Benzisoxazole Risperdal; Risperdal-M (ODT) Risperidone Autistic disorder; bipolar I disorder; schizophrenia Oral Soln: 1mg/ml; Oral Tablet: 0.25, 0.5, 1, 2, 3, 4mg; ODT: 0.25, 0.5, 1, 2, 3, 4mg IM Susp: 12.5, 25, 37.5, 50mg (Max: 50mg q2wks IM) Oral, IM Varies Varies 5YO+ (Autism) 10YO+ (Bipolar) 13YO+ (Schizo.) Selective monoaminergic antagonist with a strong affinity for 5-HT2 receptors and a slightly weaker affinity for D2 receptors
Antipsychotic; Dibenzothiazepine Seroquel; Seroquel XR Quetiapine Bipolar disorder; major depressive disorder (adjunct); manic bipolar disorder; schizophrenia Oral Tablet: 25, 50, 100, 200, 300, 400mg; ER Tablet: 50, 150, 200, 300, 400mg Oral Varies Varies 10YO+ Max: 800mg/day Antagonist at 5-HT1A, 5-HT2, D1, D2, H1, alpha1, and alpha2 receptors
Antidepressant; SSRI Celexa Citalopram Depression Oral Soln: 10mg/5ml; Oral Tablet: 10, 20, 40mg Oral 20mg QD (max 40mg/day) N/A Highly selective serotonin reuptake inhibitor (SSRI) with minimal effect of NE and DA
Antidepressant; SSRI Lexapro Escitalopram Generalized anxiety disorder; major depressive disorder Oral Soln: 5mg/5ml; Oral Tablet: 5, 10, 20mg Oral Initial = 10mg/day, may increase to 20mg/day, only after a minimum of 1 week 12YO+ 10mg/day, may increase to 20mg/day only after a minimum of 3 weeks SSRI Enhance serotonin activity in the CNS
Antidepressant; SSRI Paxil; Paxil CR Paroxetine Generalized anxiety disorder, major depressive disorder, OCD, panic disorder, PTSD, premenstrual dysphoric disorder, social phobia Oral Tablet: 10, 20, 30, 40mg; ER Tablet: 12.5, 25, 37.5mg; Oral Susp: 10mg/5ml Oral Varies IR max: 60mg/day CR max: 75mg/day N/A SSRI Enhance serotonin activity in the CNS
Antidepressant; SSRI Prozac; Sarafem Fluoxetine Bulimia nervosa; bipolar I disorder (in combo w/ olanzapine); major depressive disorder; OCD; panic disorder; premenstrual dysphoric disorder Oral Capsule: 10, 20, 40mg; Oral Capsule (Delayed Release): 90mg; Oral Soln/Syrup: 20mg/5ml; Oral Tablet: 10, 20, 60mg Oral Varies Max: 80mg/day Varies 7YO+ SSRI Enhance serotonin activity in the CNS
Created by: scottamus123