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Parkinson disease

Deprenyl MAO B inhibitor protected MPTP effects; inhibit the break down of dopamine; inhibit MPTP metablozing to MPP+(toxic) by MAO B; -protects against the effect of free radicals produced by DA metabolism;
DAT blocker blocks MPP+ from taking up by the dopamine transporter
Mazindol very potent inhibitor of DAT only need a small concentration
paraquat (bisquaternary) MPP+ analog
Rotenone lipophilic compound that easily crosses BBB high dose leads to almost complete loss of DA neurons cause tremor, immobility
alpha-synuclein positive inclusion bodies neuron affected by rotenone have these
L-DOPA Relieves PD symptoms, most effective, worst side effect DA precursor, convert to DA in the blood stream( by DOPA decarboxylase), produce nausea, blood pressure changes.
L-DOPA + Carbidopa Sinemet
MAO-B inhibiting drug Deprenyl
Carbidopa prevent the conversion of L- DOPA to DA in the blood stream inhibit DOPA carboxylase in the periphery
Dyskinesia refers to a category of movement disorders that are characterized by involuntary muscle movements
Problems with L-DOPA and SInemet DA metabolisom produce free radicals (neurotoxic) Short half lifes (3 hours), compete with food for absorption therapeutic window shrink off/off symptoms psychiatric problems
benserazide similar to carbidopa
selegiline deprenyl MAO B inhibitor
bromocriptine DA receptor agonist D2 type receptor agonist
Tobacco inhibits? MAO B
Created by: kula202



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