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Parkinson disease
Term | Definition |
---|---|
Deprenyl | MAO B inhibitor protected MPTP effects; inhibit the break down of dopamine; inhibit MPTP metablozing to MPP+(toxic) by MAO B; -protects against the effect of free radicals produced by DA metabolism; |
DAT blocker | blocks MPP+ from taking up by the dopamine transporter |
Mazindol | very potent inhibitor of DAT only need a small concentration |
paraquat (bisquaternary) | MPP+ analog |
Rotenone | lipophilic compound that easily crosses BBB high dose leads to almost complete loss of DA neurons cause tremor, immobility |
alpha-synuclein positive inclusion bodies | neuron affected by rotenone have these |
L-DOPA | Relieves PD symptoms, most effective, worst side effect DA precursor, convert to DA in the blood stream( by DOPA decarboxylase), produce nausea, blood pressure changes. |
L-DOPA + Carbidopa | Sinemet |
MAO-B inhibiting drug | Deprenyl |
Carbidopa | prevent the conversion of L- DOPA to DA in the blood stream inhibit DOPA carboxylase in the periphery |
Dyskinesia | refers to a category of movement disorders that are characterized by involuntary muscle movements |
Problems with L-DOPA and SInemet | DA metabolisom produce free radicals (neurotoxic) Short half lifes (3 hours), compete with food for absorption therapeutic window shrink off/off symptoms psychiatric problems |
benserazide | similar to carbidopa |
selegiline | deprenyl MAO B inhibitor |
bromocriptine | DA receptor agonist D2 type receptor agonist |
Tobacco inhibits? | MAO B |