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Antihistamine

Stack #180626

QuestionAnswer
Where is histamine present? It is present in practically all tissues (esp. lungs, skin and GI tract).
What does H1 receptor do? Vasodilation, Increase Capillary Permeability, Bronchonstriction, and CNS effects
What does H2 receptor do? secretion of gastric acids in stomach
What are the actions of H1 Antagonists, 1st Generation? Peripheral Effects (preventing actions of histamine at H1 receptors) and CNS effects (depression at theraputic doses so reaction time is slowed, alertness is diminished, and drowsiness is likely)
What are the uses of H1 Antagonists? mild/severe allergy, motion sickenss, insomnia and common cold
What is the difference between a 1st Generation and 2nd Generation H1 Antagonist? Sedating - 1st generation (Benadryl aka Diphenhydramine)Non Sedating - 2nd generation (Claritin, Allegra, Zyrtec)
What are some side effects of H1 Antagonists? GI (N & V, loss appetite, diarrhea, constipation), Anticholinergic, Cardiac dysrthymias, Nonsedative CNS (dizziness, incoordination, fatigue, confusion), Sedation (can impair learning and memory)
Created by: angel26885
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