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Top 200 #5

ClassBrandGenericIndicationsDose FormRouteAdult DosePed. DoseMOA
Anti-inflam, Calcineurin inhibitor, immune suppressant Restasis Cyclosporine Keratoconjunctivitis sicca 0.05% ophthalmic emulsion Eye 1 drop each eye BID (q12hr) 16 Yrs+: same as adult Thought to act as a partial immunomodulator (increases tear production)
Anti-inflam, Leukotriene Pathway Inhibitor Singulair Montelukast Asthma (treatment & prophylaxis), exercise-induced asthma (prophylaxis), perennial & seasonal allergic rhinitis Granules: 4mg; Tablets: 10mg; Chew Tabs: 4mg, 5mg Oral 10mg QPM or 2 hrs before exercise 1-5 YO: 4mg QPM; 6-14 YO: 5mg QPM; 15 YO+: 10mg QPM Leukotriene receptor antagonist. It binds to (CysLT) type-1 receptors found in human airway (smooth muscle cells and macrophages), which prevents airway edema, smooth muscle contraction and other respiratory inflammation.
Antimuscarinic, Bronchodilator Spiriva Tiotropium COPD Capsule: 18 mcg Oral 1 capsule via 2 inhalations QD using Handihaler (do not swallow capsule) N/A Long-acting, antimuscarinic agent which is often referred to as an anticholinergic. In airways, Tiotropium induces bronchodilation via inhibition of the M3 receptor on airway smooth muscle.
Anti-inflam/ Bronchodilator Combo: β2 adr. Agonist (LABA) Symbicort Budesonide/ Formoterol Asthma, COPD 80mcg/4.5mcg, 160mcg/4.5mcg Oral 2 puffs BID (either strength) Max: 4 puffs/day 12 YO+: same as adult Budesonide: anti-inflam synthetic corticosteroid w/ potent glucocorticoid & weak mineralcorticoid activity Formoterol: long-acting bronchodilator that exerts agonist effects on beta(2)-adrenergic receptors found in bronchial smooth muscle
Antitussive Tessalon Benzonatate Cough Capsule: 100mg, 200mg Oral 100-200mg TID PRN (MAX: 600mg/day and 200mg/dose) 10 Yrs+: same as adult Suppresses cough through a peripheral action, anesthetizing the stretch or cough receptors of vagal afferent fibers
Antiglaucoma, Beta-Adrenergic blocker (nonselective) Timoptic Timolol Ocular HTN, Open-angle Glaucoma, Migraine prophylaxis 0.25%, 0.5% drops or gel-forming drops Eye 1 drop in affected eye(S) QD-BID Gel forming: 1 drop QD 1 drop (either strength) QD Non-selective beta(1) and beta(2) adrenergic receptor blocking agent which reduces the vasodilator, bronchodilator, positive chronotropic & inotropic responses
Antiglaucoma, Prostaglandin Travatan Z Travoprost Raised intraocular pressure (in pts w/ open-angle glaucoma or ocular HTN) 0.004% ophthalmic soln. Eye 1 drop in affected eye(s) QPM (also max) 16 YO+ Selective FP prostanoid receptor agonist, lowers intraocular pressure (IOP) by increasing the uveoscleral outflow
Antiglaucoma, Prostaglandin Xalatan Latanoprost Ocular HTN, Open-angle Glaucoma 0.005% ophthalmic soln. Eye 1 drop in affected eye(s) QPM (also max) N/A Prostaglandin F 2-alpha analog believed to reduce IOP by increasing outflow of aqueous humor (studies suggest main MOA is increased uveoscleral outflow)
Vaccine Gardasil Human Papillomavirus Quadrivalent Vaccine Adenocarcinoma in situ of cervix; anal cancer; cervical cancer; anal, cervical, vaginal, vulva intraepithelial neoplasia, genital warts, malignant tumor of vagina/vulva(proph.) Susp. IM (Deltoid or upper thigh) 26 YO and younger: 0.5 mL IM for 3 doses at 0, 2, and 6 Months (3 dose series) 9 YO+: same as adult Development of humoral immune response against HPV types 6, 11, 16, and 18
Vaccine Pneumovax 23 Pneumococcal polysaccharide vaccine Pneumococcal vaccination Injectable: 25mcg/0.5ml SubQ, IM (Deltoid or mid-thigh) 19-64 YO: 0.5 mL IM or subQ as single dose at least 8 wks after last PCV13 Revaccination: in 5 yrs (max 2 doses) 2 YO+: same as adult Induce type-specific antibodies that enhance opsonization, phagocytosis, and killing ov pneumococci by leukocytes and other phagocytic cells
Vaccine Varivax Varicella vaccine Varicella (Varivax) prophylaxis SubQ powder for soln. 19400 PFU SubQ 0.5 mL subQ x2 doses; allow at least 4 weeks to elapse between doses 12 mos-12 yrs: 0.5 mL subQ; allow at least 3 months to elapse if 2nd dose is given Induces varicella antibodies and a cell-mediated immune response, which produce active immunity against varicella infection
Vaccine Prevnar 13 Pneumococcal conjugate vaccine Pneumococcal vaccination, 13-valent conjugate vaccine Susp. IM 0.5 mL IM followed by 1 dose of 23-valent 8 or more weeks later Primary series: 0.5 mL IM for 4 doses at 2, 4, 6, and 12-15 mos Causes a T-cell dependent immune response which signals the maturation of B-cells to produce antibodies and memory cells to pneumococcal polysaccharides
Vaccine Zostavax Zoster Vaccine Herpes zoster (Zostavax) prophylaxis SubQ powder for Soln. 19400 PFU SubQ 50 YO+: 0.65 mL subQ (FDA recommends at 50 yrs; advisory committee on immuniz practices recommends at 60 yrs N/A Induces antibodies and a cell-mediated response
Antiasthma; Anti-inflam/ Bronchodilator Combo; β2 adr. agonist (LABA) Advair Fluticasone/ Salmeterol Asthma, COPD 100/50, 250/50, 500/50; HFA: 45/21, 115/21, 230/21 Oral 1 puff BID; HFA can be 2 puffs BID 4-11 YO: 100/50mcg BID; 12 YO: any strength HFA: 2 puffs BID Fluticasone: (synthetic trifluorinated corticosteroid w/ powerful anti-inflam effects) – human glucocorticoid receptor antagonist that inhibits multiple cell types & mediator production/secretion involved in asthmatic response Salmeterol
Bronchodilator; Β2 adr. agonist Combivent Ipratropium bromide/ Albuterol Sulfate COPD (for pts requiring 2nd bronchodilator) Aerosol: 103/18mcg; Inhalation Sol’n: 100/20mcg Oral 103/18mcg: 2 puffs QID (max 12 puffs/24 hrs) 100/20mcg: 1 inhalation TID N/A Reduces bronchospasm through both anticholinergic & sympathomimetic mechanisms; Albuterol is highly selective for beta 2-adrenergic receptors leading to adenylyl cyclase activation  increase cAMP, resulting in airway smooth muscle relaxation; Ipratropium
Adrenal Glucocorticoid; Anti-inflam; Corticosteroid, (Intermediate) Flonase Fluticasone Allergic rhinitis, Asthma, Atopic dermatitis, disorder of skin (corticosteroid-responsive dermatoses), rhinitis (non-allergic) 50mcg/spray Nasal 1 spray each nostril BID or 2 sprays each nostril QD 4-11 YO: 1 spray each nostril BID or 2 sprays each nostril QD Human glucocorticoid receptor agonist
Adrenal Glucocorticoid; Anti-inflam; Corticosteroid (strong) Nasonex Mometasone Furoate Allergic rhinitis (seasonal & perennial), Asthma, Inflam hyperkeratotic dermatosis, Nasal Congestion; Nasal polyp, Seasonal allergic rhinitis (prophylaxis) 50mcg/ spray Nasal 2 sprays each nostril QD 2-11 YO: 1 spray each nostril QD Corticosteroid with anti-inflam, antipruritic, and vasoconstrictive properties. Corticosteroids inhibit the release of arachidonic acid by inducing lipocortins that inhibit phospholipase A2.
Antihistamine Patanol; Pataday Olopatadine Allergic conjunctivitis, Seasonal allergic rhinitis Patanol: 0.1%; Pataday: 0.2% Eye 0.1%: 1 drop BID (at 6-8 hr interval) 0.2%: 1 drop QD 2 YO+: same as adult Selective histamine H(1)-antagonist
Beta-2 Adrenergic Agonist; Bronchodilator; Sympathomimetic ProAir HFA; Proventil; Ventolin Albuterol Aerosol Asthma, Exercise-induced asthma (prophylaxis) 90mcg/ puff Oral 2 puffs q4-6 hrs or q4 hr PRN; Exercise-induced: 2 puffs 15-30 mins prior to exercise 4 YO+: same as adult Beta-adrenergic agonist that selectively acts on the beta (2)-adrenergic receptors of intracellular adenyl cyclase
Adrenal Glucocorticoid, Anti-Inflam, Endocrine-Metabolic Agent, GI Agent Pulmicort (oral); Rhinocort Aqua (nasal) Budesonide Asthma, Crohn’s Disease, Rhinitis (allergic & non), Ulcerative colitis 0.25mg/2ml, 0.5mg/2ml, 90mcg/ puff, 180mcg/ puff; Rhinocort: 32mcg/ spray Oral, Nasal Flexhaler: initial = 360mcg BID, then 180mcg BID (max 720mcg BID) 6 YO+: same as adult Anti-inflam synthetic corticosteroid with potent glucocorticoid and weak mineralcorticoid activity
Created by: scottamus123